Toru Takumi

Last updated: Jan 12, 2019 at 10:01

Name	Toru Takumi
E-mail	toru.takumiriken.jp
Affiliation	RIKEN(The Institute of Physical and Chemical Research)
Section	Brain Science Institute
Job title	Professor

Awards & Honors

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Mar 2017

Terumo Foundatuon Prize

Published Papers

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Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system.

Nakamura T, Nakajima K, Ohnishi T, Yoshikawa T, Nakanishi M, Takumi T, Tsuboi T, Kato T

Scientific reports 8(1) 16025 Oct 2018 [Refereed]

Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits.

Nagano M, Takumi T, Suzuki H

Scientific reports 8(1) 13675 Sep 2018 [Refereed]

Postsynaptic density proteins and their involvement in neurodevelopmental disorders.

Kaizuka T, Takumi T

Journal of biochemistry 163(6) 447-455 Jun 2018 [Refereed]

Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models.

Horder J, Petrinovic MM, Mendez MA, Bruns A, Takumi T, Spooren W, Barker GJ, Künnecke B, Murphy DG

Translational psychiatry 8(1) 106 May 2018 [Refereed]

A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.

Wu M, Takemoto M, Luo H, Xu JJ, Lu MH, Kameyama M, Takumi T, Song WJ

European journal of pharmacology 824 99-107 Apr 2018 [Refereed]

The choroid plexus is an important circadian clock component.

Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T

Nature communications 9(1) 1062 Mar 2018 [Refereed]

CNV biology in neurodevelopmental disorders.

Takumi T, Tamada K

Current opinion in neurobiology 48 183-192 Feb 2018 [Refereed]

Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5.

Mori K, Nakamura H, Kurooka H, Miyachi H, Tamada K, Sugai M, Takumi T, Yokota Y

Molecular and cellular biology Feb 2018 [Refereed]

Common Defects of Spine Dynamics and Circuit Function in Neurodevelopmental Disorders: A Systematic Review of Findings From in Vivo Optical Imaging of Mouse Models.

Nakai N, Takumi T, Nakai J, Sato M

Frontiers in neuroscience 12 412 2018 [Refereed]

Identification of genes regulating GABAergic interneuron maturation.

Fukumoto K, Tamada K, Toya T, Nishino T, Yanagawa Y, Takumi T

Neuroscience research Dec 2017 [Refereed]

Rodent models of genetic and chromosomal variations in psychiatric disorders.

Nomura J, Kannan G, Takumi T

Psychiatry and clinical neurosciences 71(8) 508-517 Aug 2017 [Refereed]

Potential contribution of tandem circadian enhancers to nonlinear oscillations in clock gene expression.

Tokuda IT, Okamoto A, Matsumura R, Takumi T, Akashi M

Molecular biology of the cell 28(17) 2333-2342 Aug 2017 [Refereed]

Functional significance of rare neuroligin 1 variants found in autism.

Nakanishi M, Nomura J, Ji X, Tamada K, Arai T, Takahashi E, Bućan M, Takumi T

PLoS genetics 13(8) e1006940 Aug 2017 [Refereed]

Skeletal Site-specific Changes in Bone Mass in a Genetic Mouse Model for Human 15q11-13 Duplication Seen in Autism.

Lewis KE, Sharan K, Takumi T, Yadav VK

Scientific reports 7(1) 9902 Aug 2017 [Refereed]

CHRONO integrates behavioral stress and epigenetic control of metabolism.

Hatanaka F, Takumi T

Annals of medicine 49(4) 352-356 Jun 2017 [Refereed]

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.

Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T

Science advances 3(6) e1603001 Jun 2017 [Refereed]

Behavioral and neuroanatomical analyses in a genetic mouse model of 2q13 duplication.

Kishimoto K, Nomura J, Ellegood J, Fukumoto K, Lerch JP, Moreno-De-Luca D, Bourgeron T, Tamada K, Takumi T

Genes to cells : devoted to molecular & cellular mechanisms 22(5) 436-451 May 2017 [Refereed]

Unusual semi-extractability as a hallmark of nuclear body-associated architectural noncoding RNAs.

Chujo T, Yamazaki T, Kawaguchi T, Kurosaka S, Takumi T, Nakagawa S, Hirose T

The EMBO journal 36(10) 1447-1462 May 2017 [Refereed]

Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism.

Wang M, Li H, Takumi T, Qiu Z, Xu X, Yu X, Bian WJ

Neuroscience bulletin 33(2) 143-152 Apr 2017 [Refereed]

Network Dynamics Mediate Circadian Clock Plasticity.

Azzi A, Evans JA, Leise T, Myung J, Takumi T, Davidson AJ, Brown SA

Neuron 93(2) 441-450 Jan 2017 [Refereed]

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.

Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y

Scientific reports 7(1) 1 Jan 2017 [Refereed]

Exome sequencing in the knockin mice generated using the CRISPR/Cas system.

Nakajima K, Kazuno AA, Kelsoe J, Nakanishi M, Takumi T, Kato T

Scientific reports 6 34703 Oct 2016 [Refereed]

FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice.

Kino Y, Washizu C, Kurosawa M, Yamada M, Doi H, Takumi T, Adachi H, Katsuno M, Sobue G, Hicks GG, Hattori N, Shimogori T, Nukina N

Scientific reports 6 35236 Oct 2016 [Refereed]

CHD8 haploinsufficiency results in autistic-like phenotypes in mice.

Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI

Nature 537(7622) 675-679 Sep 2016 [Refereed]

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization.

West JA, Mito M, Kurosaka S, Takumi T, Tanegashima C, Chujo T, Yanaka K, Kingston RE, Hirose T, Bond C, Fox A, Nakagawa S

The Journal of cell biology 214(7) 817-830 Sep 2016 [Refereed]

Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.

Wu M, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song WJ

American journal of physiology. Cell physiology 311(1) C15-23 Jul 2016 [Refereed]

Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics.

Sugiura T, Matsuda S, Kurosaka S, Nakai N, Fukumoto K, Takahashi T, Maruyama H, Imaizumi K, Matsumoto M, Takumi T

The FEBS journal 283(8) 1475-1487 Apr 2016 [Refereed]

Sequence features associated with the cleavage efficiency of CRISPR/Cas9 system.

Liu X, Homma A, Sayadi J, Yang S, Ohashi J, Takumi T

Scientific reports 6 19675 Jan 2016 [Refereed]

Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model.

Ellegood J, Nakai N, Nakatani J, Henkelman M, Takumi T, Lerch J

Autism research : official journal of the International Society for Autism Research 8(5) 545-555 Oct 2015 [Refereed]

Autism spectrum disorder model mice: Focus on copy number variation and epigenetics.

Nakai N, Otsuka S, Myung J, Takumi T

Science China. Life sciences 58(10) 976-984 Oct 2015 [Refereed]

Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice.

Hughes AT, Croft CL, Samuels RE, Myung J, Takumi T, Piggins HD

Scientific reports 5 14044 Sep 2015 [Refereed]

Transcriptome profiling of white adipose tissue in a mouse model for 15q duplication syndrome.

Liu X, Tamada K, Kishimoto R, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T

Genomics data 5 394-396 Sep 2015 [Refereed]

Model mice for 15q11-13 duplication syndrome exhibit late-onset obesity and altered lipid metabolism.

Kishimoto R, Tamada K, Liu X, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T

Human molecular genetics 24(16) 4559-4572 Aug 2015 [Refereed]

GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time.

Myung J, Hong S, DeWoskin D, De Schutter E, Forger DB, Takumi T

Proceedings of the National Academy of Sciences of the United States of America 112(29) E3920-9 Jul 2015 [Refereed]

Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping.

DeWoskin D, Myung J, Belle MD, Piggins HD, Takumi T, Forger DB

Proceedings of the National Academy of Sciences of the United States of America 112(29) E3911-9 Jul 2015 [Refereed]

Cerebellar associative sensory learning defects in five mouse autism models.

Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SS

eLife 4 e06085 Jul 2015 [Refereed]

FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.

Kino Y, Washizu C, Kurosawa M, Yamada M, Miyazaki H, Akagi T, Hashikawa T, Doi H, Takumi T, Hicks GG, Hattori N, Shimogori T, Nukina N

Acta neuropathologica communications 3 24 Apr 2015 [Refereed]

Altered Microglia in the Amygdala Are Involved in Anxiety-related Behaviors of a Copy Number Variation Mouse Model of Autism.

Shigemori T, Sakai A, Takumi T, Itoh Y, Suzuki H

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 82(2) 92-99 2015 [Refereed]

DEC2-E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter.

Tanoue S, Fujimoto K, Myung J, Hatanaka F, Kato Y, Takumi T

Frontiers in neurology 6 166 2015 [Refereed]

Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism.

Piochon C, Kloth AD, Grasselli G, Titley HK, Nakayama H, Hashimoto K, Wan V, Simmons DH, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang SS, Hansel C

Nature communications 5 5586 Nov 2014 [Refereed]

Genomic and genetic aspects of autism spectrum disorder.

Liu X, Takumi T

Biochemical and biophysical research communications 452(2) 244-253 Sep 2014 [Refereed]

Enhanced synapse remodelling as a common phenotype in mouse models of autism.

Isshiki M, Tanaka S, Kuriu T, Tabuchi K, Takumi T, Okabe S

Nature communications 5 4742 Aug 2014 [Refereed]

A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.

Goriki A, Hatanaka F, Myung J, Kim JK, Yoritaka T, Tanoue S, Abe T, Kiyonari H, Fujimoto K, Kato Y, Todo T, Matsubara A, Forger D, Takumi T

PLoS biology 12(4) e1001839 Apr 2014 [Refereed]

Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2).

Matsumura R, Matsubara C, Node K, Takumi T, Akashi M

The Journal of biological chemistry 288(51) 36548-36553 Dec 2013 [Refereed]

Helix-loop-helix protein Id2 stabilizes mammalian circadian oscillation under constant light conditions.

Adachi AA, Fujioka A, Nagano M, Masumoto KH, Takumi T, Yoshimura T, Ebihara S, Mori K, Yokota Y, Shigeyoshi Y

Zoological science 30(12) 1011-1018 Dec 2013 [Refereed]

Characterization and modeling of intermittent locomotor dynamics in clock gene-deficient mice.

Nakamura T, Takumi T, Takano A, Hatanaka F, Yamamoto Y

PloS one 8(3) e58884 2013 [Refereed]

Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach.

Mazzoccoli G, Francavilla M, Pazienza V, Benegiamo G, Piepoli A, Vinciguerra M, Giuliani F, Yamamoto T, Takumi T

Chronobiology international 29(10) 1300-1311 Dec 2012 [Refereed]

Regulation of zipcode binding protein 1 transport dynamics in axons by myosin Va.

Nalavadi VC, Griffin LE, Picard-Fraser P, Swanson AM, Takumi T, Bassell GJ

The Journal of neuroscience : the official journal of the Society for Neuroscience 32(43) 15133-15141 Oct 2012 [Refereed]

Period coding of Bmal1 oscillators in the suprachiasmatic nucleus.

Myung J, Hong S, Hatanaka F, Nakajima Y, De Schutter E, Takumi T

The Journal of neuroscience : the official journal of the Society for Neuroscience 32(26) 8900-8918 Jun 2012 [Refereed]

Animal models of psychiatric disorders that reflect human copy number variation.

Nomura J, Takumi T

Neural plasticity 2012 589524 2012 [Refereed]

Altered serotonin, dopamine and norepinepherine levels in 15q duplication and Angelman syndrome mouse models.

Farook MF, DeCuypere M, Hyland K, Takumi T, LeDoux MS, Reiter LT

PloS one 7(8) e43030 2012 [Refereed]

Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.

Rogelj B, Easton LE, Bogu GK, Stanton LW, Rot G, Curk T, Zupan B, Sugimoto Y, Modic M, Haberman N, Tollervey J, Fujii R, Takumi T, Shaw CE, Ule J

Scientific reports 2 603 2012 [Refereed]

The neurobiology of mouse models syntenic to human chromosome 15q.

Takumi T

Journal of neurodevelopmental disorders 3(3) 270-281 Sep 2011 [Refereed]

The period of the somite segmentation clock is sensitive to Notch activity.

Kim W, Matsui T, Yamao M, Ishibashi M, Tamada K, Takumi T, Kohno K, Oba S, Ishii S, Sakumura Y, Bessho Y

Molecular biology of the cell 22(18) 3541-3549 Sep 2011 [Refereed]

Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism.

Hatanaka F, Matsubara C, Myung J, Yoritaka T, Kamimura N, Tsutsumi S, Kanai A, Suzuki Y, Sassone-Corsi P, Aburatani H, Sugano S, Takumi T

Molecular and cellular biology 30(24) 5636-5648 Dec 2010 [Refereed]

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling.

Tamada K, Tomonaga S, Hatanaka F, Nakai N, Takao K, Miyakawa T, Nakatani J, Takumi T

PloS one 5(12) e15126 Dec 2010 [Refereed]

Dual-color luciferase mouse directly demonstrates coupled expression of two clock genes.

Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y

Biochemistry 49(37) 8053-8061 Sep 2010 [Refereed]

A humanoid mouse model of autism.

Takumi T

Brain & development 32(9) 753-758 Jun 2010 [Refereed]

Mutations of optineurin in amyotrophic lateral sclerosis.

Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H

Nature 465(7295) 223-226 May 2010 [Refereed]

A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.

Takarada T, Tamaki K, Takumi T, Ogura M, Ito Y, Nakamichi N, Yoneda Y

Journal of neurochemistry 110(5) 1457-1468 Sep 2009 [Refereed]

Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.

Enomoto M, Hayakawa S, Itsukushima S, Ren DY, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y

Oncogene 28 3197-3208 Sep 2009 [Refereed]

Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.

Watanabe Y, Inoue K, Okuyama-Yamamoto A, Nakai N, Nakatani J, Nibu K, Sato N, Iiboshi Y, Yusa K, Kondoh G, Takeda J, Terashima T, Takumi T

The Journal of comparative neurology 515 565-584 Aug 2009 [Refereed]

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.

Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyakawa T, Bradley A, Takumi T

Cell 137(7) 1235-1246 Jun 2009 [Refereed]

Time microscopy of circadian expression of cardiac clock gene mRNA transcription: chronodiagnostic and chrono-therapeutic implications.

Sothern RB, Cornélissen G, Yamamoto T, Takumi T, Halberg F

La Clinica terapeutica 160 ep25-34 Mar 2009 [Refereed]

TLS-GFP cannot rescue mRNP formation near spines and spine phenotype in TLS-KO.

Fujii R, Grossenbacher-Zinchuk O, Jamari I, Wang Y, Zinchuk V, Takumi T

Neuroreport 20 57-61 Jan 2009 [Refereed]

TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5.

Selamat W, Jamari I, Wang Y, Takumi T, Wong F, Fujii R

Neuroscience letters 450 163-166 Jan 2009 [Refereed]

The resetting of the circadian rhythm by Prostaglandin J2 is distinctly phase-dependent.

Koinuma S, Yagita K, Fujioka A, Takashima N, Takumi T, Shigeyoshi Y

FEBS letters 583(2) 413-418 Jan 2009 [Refereed]

Robust food anticipatory activity in BMAL1-deficient mice.

Pendergast JS, Nakamura W, Friday RC, Hatanaka F, Takumi T, Yamazaki S

PloS one 4 e4860 2009 [Refereed]

Comment on "Differential rescue of light- and food-entrainable circadian rhythms".

Mistlberger RE, Yamazaki S, Pendergast JS, Landry GJ, Takumi T, Nakamura W

Science (New York, N.Y.) 322 675; author reply 675 Oct 2008 [Refereed]

Of mice and men--universality and breakdown of behavioral organization.

Nakamura T, Takumi T, Takano A, Aoyagi N, Yoshiuchi K, Struzik ZR, Yamamoto Y

PloS one 3 e2050 Apr 2008 [Refereed]

In vivo monitoring of circadian timing in freely moving mice.

Nakamura W, Yamazaki S, Nakamura TJ, Shirakawa T, Block GD, Takumi T

Current biology : CB 18 381-385 Mar 2008 [Refereed]

A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes.

Nakahata Y, Yoshida M, Takano A, Soma H, Yamamoto T, Yasuda A, Nakatsu T, Takumi T

BMC molecular biology 9 1 Jan 2008 [Refereed]

Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.

Yoshimura A, Fujii R, Watanabe Y, Okabe S, Fukui K, Takumi T

Current biology : CB 16 2345-2351 Dec 2006 [Refereed]

Molecular mechanism of cell-autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock.

Akashi M, Ichise T, Mamine T, Takumi T

Molecular biology of the cell 17(2) 555-565 Feb 2006 [Refereed]

The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks.

Nakahata Y, Akashi M, Trcka D, Yasuda A, Takumi T

BMC molecular biology 7 5 Feb 2006 [Refereed]

Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element.

Yamamoto T, Nakahata Y, Tanaka M, Yoshida M, Soma H, Shinohara K, Yasuda A, Mamine T, Takumi T

The Journal of biological chemistry 280(51) 42036-42043 Dec 2005 [Refereed]

TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines.

Fujii R, Takumi T

Journal of cell science 118(24) 5755-5765 Dec 2005 [Refereed]

The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1.

Akashi M, Takumi T

Nature structural & molecular biology 12(5) 441-448 May 2005 [Refereed]

Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.

Sakakida Y, Miyamoto Y, Nagoshi E, Akashi M, Nakamura TJ, Mamine T, Kasahara M, Minami Y, Yoneda Y, Takumi T

The Journal of biological chemistry 280(14) 13272-13278 Apr 2005 [Refereed]

The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.

Fujii R, Okabe S, Urushido T, Inoue K, Yoshimura A, Tachibana T, Nishikawa T, Hicks GG, Takumi T

Current biology : CB 15 587-593 Mar 2005 [Refereed]

Fez1 is layer-specifically expressed in the adult mouse neocortex.

Inoue K, Terashima T, Nishikawa T, Takumi T

The European journal of neuroscience 20 2909-2916 Dec 2004 [Refereed]

The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.

Kani S, Oishi I, Yamamoto H, Yoda A, Suzuki H, Nomachi A, Iozumi K, Nishita M, Kikuchi A, Takumi T, Minami Y

The Journal of biological chemistry 279(48) 50102-50109 Nov 2004 [Refereed]

Transcriptional oscillation of canonical clock genes in mouse peripheral tissues.

Yamamoto T, Nakahata Y, Soma H, Akashi M, Mamine T, Takumi T

BMC molecular biology 5 18 Oct 2004 [Refereed]

Domain architectures and characterization of an RNA-binding protein, TLS.

Iko Y, Kodama TS, Kasai N, Oyama T, Morita EH, Muto T, Okumura M, Fujii R, Takumi T, Tate S, Morikawa K

The Journal of biological chemistry 279(43) 44834-44840 Oct 2004 [Refereed]

Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia.

Kajimoto Y, Shirakawa O, Lin XH, Hashimoto T, Kitamura N, Murakami N, Takumi T, Maeda K

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 28 1831-1839 Oct 2003 [Refereed]

Regulation by gonadal steroids of the mRNA encoding for a type I receptor for TGF-beta in the female rat hypothalamus.

Bouret S, Prevot V, Takumi T, Beauvillain JC, Mitchell V

Neuroendocrinology 76 1-7 Jul 2002 [Refereed]

Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2.

Shigeyoshi Y, Meyer-Bernstein E, Yagita K, Fu W, Chen Y, Takumi T, Schotland P, Sehgal A, Okamura H

Genes to cells : devoted to molecular & cellular mechanisms 7(2) 163-171 Feb 2002 [Refereed]

Rapid cDNA cloning by PCR screening (RC-PCR).

Takumi T

Methods in molecular biology (Clifton, N.J.) 192 385-389 2002 [Refereed]

Evidence that TGF beta may directly modulate POMC mRNA expression in the female rat arcuate nucleus.

Bouret S, Chuoi-Mariot MT, Prevot V, Croix D, Takumi T, Jegou S, Vaudry H, Beauvillain JC, Mitchell V

Endocrinology 142 4055-4065 Sep 2001 [Refereed]

Inhibition of cardiac delayed rectifier K+ currents by an antisense oligodeoxynucleotide against IsK (minK) and over-expression of IsK mutant D77N in neonatal mouse hearts.

Ohyama H, Kajita H, Omori K, Takumi T, Hiramoto N, Iwasaka T, Matsuda H

Pflugers Archiv : European journal of physiology 442 329-335 Jun 2001 [Refereed]

Evidence that members of the TGFbeta superfamily play a role in regulation of the GnRH neuroendocrine axis: expression of a type I serine-threonine kinase receptor for TGRbeta and activin in GnRH neurones and hypothalamic areas of the female rat.

Prevot V, Bouret S, Croix D, Takumi T, Jennes L, Mitchell V, Beauvillain JC

Journal of neuroendocrinology 12 665-670 Jul 2000 [Refereed]

A putative transcription factor with seven zinc-finger motifs identified in the developing suprachiasmatic nucleus by the differential display PCR method.

Maebayashi Y, Shigeyoshi Y, Takumi T, Okamura H

The Journal of neuroscience : the official journal of the Society for Neuroscience 19 10176-10183 Nov 1999 [Refereed]

A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1.

Takumi T, Nagamine Y, Miyake S, Matsubara C, Taguchi K, Takekida S, Sakakida Y, Nishikawa K, Kishimoto T, Niwa S, Okumura K, Okamura H

Genes to cells : devoted to molecular & cellular mechanisms 4(1) 67-75 Jan 1999 [Refereed]

A light-independent oscillatory gene mPer3 in mouse SCN and OVLT.

Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan L, Young MW, Okamura H

The EMBO journal 17(16) 4753-4759 Aug 1998 [Refereed]

A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus.

Takumi T, Matsubara C, Shigeyoshi Y, Taguchi K, Yagita K, Maebayashi Y, Sakakida Y, Okumura K, Takashima N, Okamura H

Genes to cells : devoted to molecular & cellular mechanisms 3(3) 167-176 Mar 1998 [Refereed]

Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1.

Tada Y, Horio Y, Takumi T, Terayama M, Tsuji L, Copeland NG, Jenkins NA, Kurachi Y

Genomics 45(3) 629-630 Nov 1997 [Refereed]

Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression.

Tsuji L, Takumi T, Imamoto N, Yoneda Y

FEBS letters 416(1) 30-34 Oct 1997 [Refereed]

Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4) to the mouse chromosome 15.

Morishige K, Takumi T, Takahashi N, Koyama H, Kurachi H, Miyake A, Murata Y, Copeland NG, Gilbert DJ, Jenkins NA, Kurachi Y

Mammalian genome : official journal of the International Mammalian Genome Society 8(9) 699-700 Sep 1997 [Refereed]

Use of PCR for cDNA library screening.

Takumi T

Methods in molecular biology (Clifton, N.J.) 67 339-344 1997 [Refereed]

Distinct localization of two serine-threonine kinase receptors for activin and TGF-beta in the rat brain and down-regulation of type I activin receptor during peripheral nerve regeneration.

Morita N, Takumi T, Kiyama H

Brain research. Molecular brain research 42(2) 263-271 Dec 1996 [Refereed]