2006年2月
Molecular mechanism of cell-autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock
MOLECULAR BIOLOGY OF THE CELL
- ,
- ,
- ,
- 巻
- 17
- 号
- 2
- 開始ページ
- 555
- 終了ページ
- 565
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1091/mbc.E05-05-0396
- 出版者・発行元
- AMER SOC CELL BIOLOGY
Although circadian transcription of Period2 (Per2) is fundamental for the generation of circadian rhythm, the molecular mechanism remains unclear. Here we report that cell-autonomous circadian transcription of Per2 is driven by two transcriptional elements, one for rhythm generation and the other for phase control. The former contains the E-box-like sequence (CACGTT) that is sufficient and indispensable to drive oscillation, and indeed circadian transcription factors site-specifically bind to it. Furthermore, the nature of this atypical E-box is different from that of the classical circadian E-box. The current feedback loop model is based mainly on Period1. Our results provide not only compelling evidence in support of this model but also an explanation for a general basic mechanism to produce various patterns in the phase and amplitude of cell-autonomous circadian gene expression.
- リンク情報
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- DOI
- https://doi.org/10.1091/mbc.E05-05-0396
- CiNii Articles
- http://ci.nii.ac.jp/naid/30018379453
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16280364
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000235117300001&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1091/mbc.E05-05-0396
- ISSN : 1059-1524
- CiNii Articles ID : 30018379453
- PubMed ID : 16280364
- Web of Science ID : WOS:000235117300001