2017年1月
NEUROSCIENCE Overlapping memory trace indispensable for linking, but not recalling, individual memories
SCIENCE
- 巻
- 355
- 号
- 6323
- 開始ページ
- 398
- 終了ページ
- 402
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.aal2690
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.
- リンク情報
- ID情報
-
- DOI : 10.1126/science.aal2690
- ISSN : 0036-8075
- eISSN : 1095-9203
- PubMed ID : 28126819
- Web of Science ID : WOS:000393172800040