論文

査読有り 国際誌
2020年3月

Relationship between thin physique at 6 years and metabolic disease risks in middle-aged Japanese women: The Suita study.

The journal of obstetrics and gynaecology research
  • Shinji Katsuragi
  • ,
  • Tomonori Okamura
  • ,
  • Yoshihiro Kokubo
  • ,
  • Makoto Watanabe
  • ,
  • Aya Higashiyama
  • ,
  • Tomoaki Ikeda
  • ,
  • Yoshihiro Miyamoto

46
3
開始ページ
517
終了ページ
526
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/jog.14206

AIM: We previously reported that female babies born small developed cardiovascular risks in middle age. The present study was conducted using the same cohort to examine the relationship between physique at 6 years and the metabolic disease risk in middle age. METHODS: Data collected from 721 women aged 41-69 years who underwent a medical examination at a single institution between 2007 and 2008 were retrospectively examined. We collected data from medical examinations and a questionnaire on physique (thin, normal, and fat) at 6 years. The relationship between birthweight and physique at 6 years was investigated. RESULTS: Among females who were born small (< 2500 g), 80%, 16%, and 4% became thin, normal, or fat, respectively, by 6 years. Physique at 6 years had a negative relationship with future triglyceride, fasting glucose, HbA1C , insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels and a positive relationship with high-density lipoprotein cholesterol levels. CONCLUSION: Although our findings may be specific to the study population, physique at 6 years had a negative relationship with the metabolic disease risk in middle-aged Japanese women. Insulin and MOMA-IR levels negatively correlated with physique at 6 years, and development from low birthweight infants to childhood obesity was rare in this cohort.

リンク情報
DOI
https://doi.org/10.1111/jog.14206
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31960522

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