論文

査読有り 最終著者 国際誌
2021年8月

Exacerbation of pulmonary cryptococcosis associated with enhancement of Th2 response in the postpartum period.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • Shota Miyoshi
  • ,
  • Naohiro Oda
  • ,
  • Yuka Gion
  • ,
  • Takahiro Taki
  • ,
  • Reo Mitani
  • ,
  • Ichiro Takata
  • ,
  • Akihiko Taniguchi
  • ,
  • Yasuharu Sato
  • ,
  • Nobuaki Miyahara

27
8
開始ページ
1248
終了ページ
1250
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jiac.2021.03.025

Cryptococcosis is an invasive mycosis that has become increasingly prevalent in immunocompromised patients. Pregnant women are also one of the risk populations for cryptococcosis. Reversal of Th2 to Th1 response following resolution of immunosuppression during the postpartum period can lead to overt clinical manifestations of a previously silent infection, resembling an immune reconstitution inflammatory syndrome. Here, we report a case of a 30-year-old woman who had an exacerbation of pulmonary cryptococcosis in the postpartum period mimicking an immune reconstitution inflammatory syndrome. In the present case, chest computed tomography showed multiple small nodules on the day of the delivery; however, pulmonary cryptococcosis, which was subclinical during pregnancy, rapidly worsened to mass-like consolidation at one month after the delivery. Pathohistological examination of the lung specimen showed lung parenchyma infiltration with histiocytes and numerous lymphocytes without granulomatous formations, and a small number of yeast-like organisms consistent with Cryptococcus without capillary involvement. Immunohistochemical staining showed predominance of CD3+ cells and CD4+ cells over CD8+ cells. In addition, GATA3+ cells dominated over T-bet + cells. These data suggested exacerbation of pulmonary cryptococcosis associated with enhancement of Th2 response in the postpartum period.

リンク情報
DOI
https://doi.org/10.1016/j.jiac.2021.03.025
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33840597
ID情報
  • DOI : 10.1016/j.jiac.2021.03.025
  • PubMed ID : 33840597

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