論文

査読有り
2017年1月

Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice

BRITISH JOURNAL OF NUTRITION
  • Tatsuro Egawa
  • ,
  • Satoshi Tsuda
  • ,
  • Ayumi Goto
  • ,
  • Yoshitaka Ohno
  • ,
  • Shingo Yokoyama
  • ,
  • Katsumasa Goto
  • ,
  • Tatsuya Hayashi

117
1
開始ページ
21
終了ページ
29
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1017/S0007114516004591
出版者・発行元
CAMBRIDGE UNIV PRESS

Diets enriched with advanced glycation end products (AGE) have recently been related to muscle dysfunction processes. However, it remains unclear whether long-term exposure to an AGE-enriched diet impacts physiological characteristics of skeletal muscles. Therefore, we explored the differences in skeletal muscle mass, contractile function and molecular responses between mice receiving a diet high in AGE (H-AGE) and low in AGE (L-AGE) for 16 weeks. There were no significant differences between L-AGE and H-AGE mice with regard to body weight, food intake or epididymal fat pad weight. However, extensor digitorum longus (EDL) and plantaris (PLA) muscle weights in H-AGE mice were lower compared with L-AGE mice. Higher levels of N-e-(carboxymethyl)-L-lysine, a marker for AGE, in EDL muscles of H-AGE mice were observed compared with L-AGE mice. H-AGE mice showed lower muscle strength and endurance in vivo and lower muscle force production of PLA muscle in vitro. mRNA expression levels of myogenic factors including myogenic factor 5 and myogenic differentiation in EDL muscle were lower in H-AGE mice compared with L-AGE mice. The phosphorylation status of 70-kDa ribosomal protein S6 kinase Thr(389), an indicator of protein synthesis signalling, was lower in EDL muscle of H-AGE mice than that of L-AGE mice. These findings suggest that long-term exposure to an AGE-enriched diet impairs skeletal muscle growth and muscle contractile function, and that these muscle dysfunctions may be attributed to the inhibition of myogenic potential and protein synthesis.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1017/S0007114516004591
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28093090
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000395508700003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1017/S0007114516004591
  • ISSN : 0007-1145
  • eISSN : 1475-2662
  • PubMed ID : 28093090
  • Web of Science ID : WOS:000395508700003

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