J-GLOBAL         Last updated: Oct 17, 2019 at 18:00


We have developed a novel screening system for PET probes visualizing native pathogenic protein aggregates in human brain. This system uses tiny stainless chips to make a number of small frozen native brain sections, and imaging mass spectrometry is used for selection of the chemicals with high affinity to the protein aggregates in brain sections.

Research Areas


Academic & Professional Experience

Apr 2016
Researcher, Toyohashi University of Technology
Apr 2015
Mar 2016
Researcher, Laboratory of Radiation Safety, National Centre for Geriatrics and Gerontology
Apr 2011
Mar 2015
Researcher, Department of Drug Discovery, Natl Center Geriatrics Gerontol
Sep 2010
Feb 2011
Researcher, Institute for Biotechnology, Univ Cambridge
Apr 1995
Mar 2010
Research Associate, Fac Life Sci, Tokyo Univ Pharm Life Sci
- Research Associate,
Tokyo University of Pharmacy and Life Science


Graduate School, Division of Natural Science, Osaka University
Faculty of Science, Nagoya University

Published Papers

Lu M, Williamson N, Boschetti C, Ellis T, Yoshimi T, Tunnacliffe A
Biotechnology and bioengineering   112(9) 1883-1892   Sep 2015   [Refereed]
T Yoshimi, S Kawabata, S Taira, A Okuno, R Mikawa, S Murayama, K Tanaka, O Takikawa
Analyst   140 7202-7208   Aug 2015   [Refereed]
Wright O, Zhang L, Liu Y, Yoshimi T, Zheng Y, Tunnacliffe A
Journal of peptide science : an official publication of the European Peptide Society   19(2) 74-83   Feb 2013   [Refereed]
Wright O*, Yoshimi T*, Tunnacliffe A (*Equally contributed)
New biotechnology   29(3) 352-358   Feb 2012   [Refereed]
Goto Y, Kajiwara M, Yanagisawa Y, Hirose H, ○Yoshimi T, Umemura M, Nakano H, Takahashi S, Shida Y, Iguchi T, Takahashi Y, Miura T.
J. Mollus. Stud.   78(2) 197-204   Feb 2012   [Refereed]
Yoshimi T, Hashimoto F, Takahashi S, Takahashi Y
In vitro cellular & developmental biology. Animal   46(8) 664-672   Sep 2010   [Refereed]
○Yoshimi T, Odagiri K, Hiroshige Y, Yokobori S, Takahashi Y, Sugaya Y, Miura T.
Environ Toxicol Pharmacol.   28(2) 294-301   Sep 2009   [Refereed]
MANABE Tomoko, TAKAHASHI Yuji, YOSHIMI Tatsuya, MIURA Takashi, SUGAYA Yoshio
Jpn. J. Environ. Toxicol.   10(1) 51-57   2007
An acute toxicity test for first-instar chironomid larvae was improved by using a Teflon sheet to prevent larvae from being trapped at the water surface during a 48-h test period. The improved procedure ensured that OECD test guideline 202 would b...
12. Manabe T, Takahashi Y, Yoshimi T, Miura T, Sugaya Y.
Jpn. J. Environ. Toxicol   10(1) 51-57   2007   [Refereed]
Yoshimi T, Nakamura N, Shimada S, Iguchi K, Hashimoto F, Mochitate K, Takahashi Y, Miura T
European journal of cell biology   84 555-566   Jun 2005   [Refereed]
Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3.
Nakamura N, Yoshimi T, Miura T
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research   13(4) 195-203   Apr 2002   [Refereed]
Yoshimi T, Minowa K, Karouna-Renier NK, Watanabe C, Sugaya Y, Miura T
Journal of biochemical and molecular toxicology   16(1) 10-17   2002   [Refereed]
Hypoxic induction of prolyl 4-hydroxylase a(I) in cultured cells. Takahashi.Y., Takahashi,S., Shiga, Y., Yoshimi, T., Miura, T.
J. Biol. Chem.   269,28598-28605    2000
Hypoxia-induced expression of phosphoglycerate mutase B in fibroblasts. Takahashi, Y., Takahashi, S.,Yoshimi, T., Miura, T.
Eur. J. Biochem.   254, 497-504    1998
Oxygen tension regulates heme oxygenase-1 gene expression in mammalian cell lines. Takahashi, S., Takahashi, Y., Yoshimi,T., Miura, T.
Cell Biochem. Funct.   16, 183-193    1998
Ozone inhalation increases the mRNA level of g-glutamyl transferase and heme oxygenase-1 in the rat lung. Takahashi, Y., Takahashi, S., Yoshimi T. et al.
Biochem. Pharmacol.   53, 1061-1064    1997
Expression of several muscle-specific genes during differentiation of cultured quail pineal body cells under artificial (high NaCl) conditions. Tatsuya Yoshimi, Masahiko Nakamura, and Akira Asano
Differentiation   59, 307-319    1995
Tatsuya Yoshimi, Naotoshi Mimura, Saburo Aimoto, Akira Asano


ヒト血清中のアミロイドβ分解活性の特性分析(Characterization of Amyloid-β Degrading Activity in Human Serum)
Mikawa Ryuta, Okuno Alato, Takayanagi Akiko, Okada Ken, Yoshimi Tatsuya, Takikawa Osamu
基礎老化研究   38(2) 66-66   May 2014
肺芽外植培養においてHoxおよびFox因子は形態形成を調節する(Hox and Fox factors modulate morphogenesis of lung bud explant culture)
Yoshimi Tatsuya, Hashimoto Fumiko, Takahashi Yuji
Cell Structure and Function   30(Suppl.) 32-32   Jun 2005
摘出肺芽培養でのアンチセンスHoxB3による発達抑制(Antisense oligonucleotides against HoxB3 suppress embryonic lung development in explant culture system)
Hashimoto Fumiko, Yoshimi Tatsuya, Nakamura Nobuatsu, Iguchi Koichi, Mochidate Katsumi, Miura Takashi, Takahashi Yuji
生化学   76(8) 974-974   Aug 2004
ホメオボックス因子は肺細胞分化においてFox-転写因子の発現を調節する(Homeobox factor modulates expressions of Fox-transcription factor during lung cell differentiation)
Yoshimi Tatsuya, Nakamura Nobuatsu, Shimada Sayaka, Iguchi Koichi, Hashimoto Fumiko, Takahashi Yuji, Miura Takashi
Cell Structure and Function   29(Suppl.) 81-81   May 2004
Homeobox factor modulates expressions of Fox-transcription factor during lung cell differentiation
Yoshimi Tatsuya, Nakamura Nobuatsu, Shimad Sayaka, Iguch Koichi, Hashimoto Fumiko, Takahashi Yuji, Miura Takashi
CELL STRUCTURE AND FUNCTION   29 81   May 2004   [Refereed]
肺上皮細胞発達中のFoxおよびHox転写因子の関与(Involvement of Fox and Hox-transcription factors during lung epithelial cell development)
Yoshimi Tatsuya, Nakamura Nobuatsu, Shimada Sayaka, Iguchi Koichi, Hashimoto Fumiko, Takahashi Yuji, Miura Takashi
生化学   75(8) 845-845   Aug 2003
Yoshimi Tatsuya, Sekine Momoko, Hiraide Kyoko, Miura Takashi
Cell Structure and Function   26(5) 440-440   Oct 2001
In vitro培養系を用いた肺内皮細胞分化の研究
Yoshimi Tatsuya, Takahashi Yuji, Takahashi Shigeru, Miura Takashi
Cell Structure and Function   24(6) 666-666   Dec 1999
Nakamura Nobuatsu, Yoshimi Tatsuya, Takahashi Yuji, Takahashi Shigeru, Miura Takashi
Cell Structure and Function   24(6) 666-666   Dec 1999
Studies on Lung Epithelial Cell differentiation Using in Vitro Culture System
Cell Structure and Function   24(6) 666   1999
In vitro培養系を用いる肺上皮細胞分化の研究
Yoshimi Tatsuya, Takahashi Yuji, Takahashi Shigeru, Miura Takashi
Cell Structure and Function   23(Suppl.) 130-130   Aug 1998
Studies on Lung Epithelial Cell Differentiation Using in Vitro Culture System
Cell Structure and Function   23(supplement) 130   1998
Studies on differentiation of lung epithelial cells using in vitro culture system.
Cell Structure and Function   22(6) 811   1997
Studies on differentiation of lung epithelial cells using in vitro culture system.
Cell Structure and Function   21(6) 618   1996
Trans-Differentiation of Embryonic Quail Pineal Body Cells to Myoblastic Cells and Myotubes.
Journal of Cellular Biochemistry suppl.   18D 474   1994
Studies on Differentiation Mechanisms from Pineal Body Cells to Muscle Cells.
Yoshimi Tatsuya
Cell Structure and Function   18(6) 551-551   Dec 1993
Studies on Transdifferentiation Mechanisms from Pineal Body Cells to Muscle Cells : Expression of Muscle Specific Molecules.

Conference Activities & Talks

Novel PET Probe Screening System for Tau Aggregates using Imaging Mass Spectrometry [Invited]
18 Oct 2014   


Detection of stress-induced genes in the midge, Chironomus yoshimatsui, by environmental pollutants.
1998 - 2005

Research Grants & Projects

Exploration and development of diagnostic and therapeutic targets for non-inflammatory liver cancer through focused analyses on tumor microenvironment
Project Year: Apr 2015 - Mar 2017    Investigator(s): KANTO Tatsuya
Development of high-throughput assay system for circulating miRNA
We have been developing miRNA detection system using an ultrasensitive semiconductor sensor. We tried to bind the cDNA on the sensor using a silane coupling reagent for the miRNA d...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Tatsuya YOSHIMI
1.Stress genes in the midge, Chironomus ;We have screened and sequenced heat shock protein genes for hsp70 and hsc70 (heat shock protein-cognate). Homology analysis and their heat-idusibility test showed their stress-response under gene expression...
Studies on regulatory factors During Lung Cell Development.
Project Year: 1995   
Detection of Endocrine Disruptor Influence on Lung Cell Differentiation System
Total environmental assessment for chemicals in the fresh water sediment using stress-gene expression of the midge, chironomus.
Grant-in-Aid for Scientific Research
Project Year: 1998