論文

査読有り
2017年10月

A long-range cis-regulatory element for class I odorant receptor genes

NATURE COMMUNICATIONS
  • Tetsuo Iwata
  • ,
  • Yoshihito Niimura
  • ,
  • Chizuru Kobayashi
  • ,
  • Daichi Shirakawa
  • ,
  • Hikoyu Suzuki
  • ,
  • Takayuki Enomoto
  • ,
  • Kazushige Touhara
  • ,
  • Yoshihiro Yoshihara
  • ,
  • Junji Hirota

8
1
開始ページ
885
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-017-00870-4
出版者・発行元
NATURE PUBLISHING GROUP

Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that is conserved through mammalian species from the platypus to humans. The J element regulates most class I genes expression by exerting an effect over similar to 3 megabases within the whole cluster. Deletion of the trans J element increases the expression frequencies of class I genes from the intact J allele, indicating that the allelic exclusion of class I genes depends on the activity of the J element. Our data reveal a long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1038/s41467-017-00870-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29026079
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000412860000010&DestApp=WOS_CPL

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