論文

査読有り
2002年12月

Gabapentin - Actions on adult superficial dorsal horn neurons

NEUROPHARMACOLOGY
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回数 : 102
  • KA Moore
  • ,
  • H Baba
  • ,
  • CJ Woolf

43
7
開始ページ
1077
終了ページ
1081
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0028-3908(02)00226-5
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Despite identification of GABA(B) receptors with gb1a-gb2 composition and the alpha2delta calcium channel subunit as putative molecular targets for gabapentin (GBP), its cellular mechanism of action has remained elusive. Therefore, we have used an in vitro spinal cord slice preparation to study the effects of GBP on lamina 11 neurons. The frequency and amplitude of spontaneous EPSCs and IPSCs were unaffected by GBP, suggesting presynaptic neurotransmitter release is not regulated. Direct modulation of postsynaptic membrane excitability is also unlikely since the level of holding current required to maintain neurons at -70, 0 and +45 mV was unaffected by GBP. Effects on excitatory and inhibitory synaptic transmission were variable across the population. Primary afferent-evoked fast glutamatergic EPSCs were unaffected by GBP, while evoked NMDA receptor-mediated EPSCs and IPSCs were variably affected. In contrast, GBP enhanced responses to bath applied NMDA in 71% of neurons. Thus, in adult rat dorsal horn, synaptic and extrasynaptic NMDA receptors may be differentially regulated by GBP perhaps due to differences in subunit composition. (C) 2002 Elsevier Science Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/S0028-3908(02)00226-5
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000180613400004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0028-3908(02)00226-5
  • ISSN : 0028-3908
  • Web of Science ID : WOS:000180613400004

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