論文

2019年6月1日

Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer

Journal of Pharmaceutical Sciences
  • Hiromasa Uchiyama
  • ,
  • Yuhei Wada
  • ,
  • Yuta Hatanaka
  • ,
  • Yoshiyuki Hirata
  • ,
  • Masahiko Taniguchi
  • ,
  • Kazunori Kadota
  • ,
  • Yuichi Tozuka

108
6
開始ページ
2033
終了ページ
2040
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.xphs.2019.01.007

© 2019 American Pharmacists Association® The effect of composite formation between α-glucosyl stevia (Stevia-G) and hydrophilic polymers on solubility and permeability enhancement of quercetin hydrate (QUE) was evaluated. Polyvinylpyrrolidone K-30 (PVP), hydroxypropyl methylcellulose 2910-E (HPMC), and hydroxypropyl cellulose SSL (HPC) were selected as candidate hydrophilic polymers. Fluorescence studies with pyrene and curcumin suggested composite formation occurs between Stevia-G aggregate and polymers. Furthermore, the strength of interaction between Stevia-G aggregate and polymers was as follows: PVP > HPMC > HPC. Evaporated particles (EVPs) of QUE with Stevia-G and polymers showed synergic QUE solubility enhancement. Solubility of QUE from the EVPs was enhanced in the following order: Stevia-G/PVP > Stevia-G/HPMC > Stevia-G/HPC, in accordance with the degree of interaction. Enhanced membrane permeability of QUE from the EVPs of Stevia-G/PVP was confirmed using Caco-2 cells. The amount of QUE that permeated Caco-2 cells from the EVPs of Stevia-G/PVP was 13.7-, 4.7-, and 2.1-fold higher than that of the untreated QUE powder, EVPs of Stevia-G, and EVPs of PVP, respectively. These results indicated that the composite formed by Stevia-G and PVP can dramatically enhance the solubility and membrane permeability of QUE.

リンク情報
DOI
https://doi.org/10.1016/j.xphs.2019.01.007
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30653971
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061059571&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85061059571&origin=inward
ID情報
  • DOI : 10.1016/j.xphs.2019.01.007
  • ISSN : 0022-3549
  • eISSN : 1520-6017
  • PubMed ID : 30653971
  • SCOPUS ID : 85061059571

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