2022年4月
Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report.
Journal of diabetes investigation
- 巻
- 13
- 号
- 4
- 開始ページ
- 741
- 終了ページ
- 745
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/jdi.13715
- 出版者・発行元
- WILEY
Here, we report a case of allogeneic islet transplantation in Japan. A 48-year-old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient's T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen-specific CD8(+) T-cell responses before the deterioration of pancreatic beta-cell function, indicating the possibility of the non-invasive detection of pancreatic beta-cell damage due to recurrent autoimmunity.
- リンク情報
- ID情報
-
- DOI : 10.1111/jdi.13715
- ISSN : 2040-1124
- PubMed ID : 34792297
- PubMed Central 記事ID : PMC9017629