2006年5月
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells
JOURNAL OF CELL BIOLOGY
- 巻
- 173
- 号
- 3
- 開始ページ
- 333
- 終了ページ
- 339
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1083/jcb.200511124
- 出版者・発行元
- ROCKEFELLER UNIV PRESS
Melanoblasts (Mbs) are thought to be strictly regulated by cell-cell interactions with epidermal keratinocytes, although the precise molecular mechanism of the regulation has been elusive. Notch signaling, whose activation is mediated by cell-cell interactions, is implicated in a broad range of developmental processes. We demonstrate the vital role of Notch signaling in the maintenance of Mbs, as well as melanocyte stem cells (MSCs). Conditional ablation of Notch signaling in the melanocyte lineage leads to a severe defect in hair pigmentation, followed by intensive hair graying. The defect is caused by a dramatic elimination of Mbs and MSCs. Furthermore, targeted overexpression of Hes1 is sufficient to protect Mbs from the elimination by apoptosis. Thus, these data provide evidence that Notch signaling, acting through Hes1, plays a crucial role in the survival of immature Mbs by preventing initiation of apoptosis.
- リンク情報
- ID情報
-
- DOI : 10.1083/jcb.200511124
- ISSN : 0021-9525
- PubMed ID : 16651378
- Web of Science ID : WOS:000237371000003