論文

査読有り
2016年10月

Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, openlabel, triple-arm trial

SCIENTIFIC REPORTS
  • Tatsuya Kondo
  • ,
  • Rieko Goto
  • ,
  • Kaoru Ono
  • ,
  • Sayaka Kitano
  • ,
  • Mary Ann Suico
  • ,
  • Miki Sato
  • ,
  • Motoyuki Igata
  • ,
  • Junji Kawashima
  • ,
  • Hiroyuki Motoshima
  • ,
  • Takeshi Matsumura
  • ,
  • Hirofumi Kai
  • ,
  • Eiichi Araki

6
開始ページ
35690
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep35690
出版者・発行元
NATURE PUBLISHING GROUP

Activation of heat shock response ( HSR) improves accumulated visceral adiposity and metabolic abnormalities in type 2 diabetes. To identify the optimal intervention strategy of the activation of the HSR provided by mild electrical stimulation ( MES) with heat shock ( HS) in type 2 diabetes. This study was a prospective, frequency-escalating, randomized, open-label, triple-arm trial in Japan. A total of 60 obese type 2 diabetes patients were randomized into three groups receiving two, four, or seven treatments per week for 12 weeks. No adverse events were identified. MES + HS treatment ( when all three groups were combined), significantly improved visceral adiposity, glycemic control, insulin resistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to baseline. The reduction in HbA1c was significantly greater among those treated four times per week (-0.36%) or seven times per week (-0.65%) than among those treated two times per week (-0.10%). The relative HbA1c levels in seven times per week group was significantly decreased when adjusted by two times per week group (-0.55%. p = 0.001). This research provides the positive impact of MES + HS to treat obese patients with type 2 diabetes mellitus.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1038/srep35690
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27759092
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000385699000001&DestApp=WOS_CPL

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