Toshiki Uchihara - My portal

Profile Information

Affiliation: Clinical Professor, Tokyo Medical and Dental University
: 臨床教授, 東京医科歯科大学
: (Concurrent)神経病理非常勤講師, 難治疾患研究所

Degree: PhD(Tokyo Medical and Dental University)

Researcher number: 10223570
J-GLOBAL ID: 201201004979589670
researchmap Member ID: B000219628

External link: http://kaken.nii.ac.jp/ja/r/10223570

ヒト脳病変の広がりと臨床像の関連を明らかにして、より良い診断や治療に結びつけるのが我々の研究室のスタンスです。個々の剖検例の解析と多数例の横断的研究を通して、臨床や病理の現場と遺伝子や分子のつながりを明らかにするのが目標です。このために、多重染色、3次元解析、免疫電顕等の新しい手法を開発してリアルな病態に迫ろうとしています。

Research Interests

Research Areas

Research History

2011

Chief, Tokyo Metropolitan Institute of Medical Science, Lab of Structural Neuropathology
2001 - 2010

senior researcher, Tokyo Metropolitan Institute of Neuroscience
1997 - 2001

staff scientist, Tokyo Metropolitan Institute of Neuroscience
1990 - 1997

staff neurologist, Tokyo Medical and Dental Univ Hosp
1995 - 1996

boursier, gouvernement francais
1994 - 1996

visiting scientist, Laboratoire Raymond Escourolle, Neuropathologie, Hopital de la Salpetriere
1988 - 1990

Trainee, Tokyo Institute of Psychiatry, Neuropathology
1984 - 1988

Junior Neurologist, Tokyo Medical and Dental Univ Hosp, Musashino Red Cross Hosp, Asahi General Hosp
1982 - 1984

Resident (Internal Medicine), University of Hawaii, postgraduate training program at Okinawa Chubu Hospital

Education

Apr, 1976 - Mar, 1982

Tokyo Medical and Dental University
Apr, 1973 - Mar, 1976

High School Shuyukan

Committee Memberships

Papers

Correlative Magnetic Resonance Imaging and Autopsy Findings in A Patient with Coagulation Necrosis Treated with Tissue Plasminogen Activator

Miki Suzuki, Toshiki Uchihara, Shuta Toru, Yuan Bae, Toru Igari, Masanobu Kitagawa, Shinichiro Uchiyama, Katsuiku Hirokawa, Takayoshi Kobayashi

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 21(6) 512-514, Aug, 2012 Peer-reviewed
Tangle evolution linked to differential 3-and 4-repeat tau isoform deposition: a double immunofluorolabeling study using two monoclonal antibodies

Toshiki Uchihara, Makoto Hara, Ayako Nakamura, Katsuiku Hirokawa

HISTOCHEMISTRY AND CELL BIOLOGY, 137(2) 261-267, Feb, 2012 Peer-reviewed
Pale Neurites, Premature a-Synuclein Aggregates with Centripetal Extension from Axon Collaterals

Toshiro Kanazawa, Eijiro Adachi, Satoshi Orimo, Ayako Nakamura, Hidehiro Mizusawa, Toshiki Uchihara

BRAIN PATHOLOGY, 22(1) 67-78, Jan, 2012 Peer-reviewed
Supranuclear ophthalmoparesis and vacuolar degeneration of the cerebral white matter in amyotrophic lateral sclerosis: A clinicopathological study

Takahiro Takeda, Toshiki Uchihara, Yoko Mochizuki, Akihito Ishihara, Ayako Nakamura, Shoichi Sasaki, Shinichiro Uchiyama, Makoto Iwata, Toshio Mizutani

AMYOTROPHIC LATERAL SCLEROSIS, 13(1) 74-83, Jan, 2012 Peer-reviewed
Differential expression of 14-3-3 protein isoforms in developing rat hippocampus, cortex, rostral migratory stream, olfactory bulb, and white matter

Takahiko Umahara, Toshiki Uchihara, Ayako Nakamura, Toshihiko Iwamoto

BRAIN RESEARCH, 1410 1-11, Sep, 2011 Peer-reviewed
Sialidosis type I with neoplasms in siblings: the first clinical cases

Yohsuke Yagi, Akira Machida, Shuta Toru, Takayoshi Kobayashi, Toshiki Uchihara

NEUROLOGICAL SCIENCES, 32(4) 737-738, Aug, 2011 Peer-reviewed
Perivascular orientation of astrocytic plaques and tuft-shaped astrocytes

Katsuhiko Shibuya, Saburo Yagishita, Ayako Nakamura, Toshiki Uchihara

BRAIN RESEARCH, 1404 50-54, Aug, 2011 Peer-reviewed
Expanding morphological dimensions in neuropathology, from sequence biology to pathological sequences and clinical consequences

Toshiki Uchihara

NEUROPATHOLOGY, 31(3) 201-207, Jun, 2011 Peer-reviewed
Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques

Takahiko Umahara, Toshiki Uchihara, Shingo Yamada, Takao Hashimoto, Jiro Akimoto, Jo Haraoka, Toshihiko Iwamoto

ATHEROSCLEROSIS, 215(2) 392-398, Apr, 2011 Peer-reviewed
Specific Detection of Pathological Three-repeat Tau after Pretreatment with Potassium Permanganate and Oxalic Acid in PSP/CBD Brains

Toshiki Uchihara, Ayako Nakamura, Katsuhiko Shibuya, Saburo Yagishita

BRAIN PATHOLOGY, 21(2) 180-188, Mar, 2011 Peer-reviewed
Valosin-containing Protein (VCP) in Novel Feedback Machinery between Abnormal Protein Accumulation and Transcriptional Suppression

Masaaki Koike, Junpei Fukushi, Yuzuru Ichinohe, Naoki Higashimae, Masahiko Fujishiro, Chiyomi Sasaki, Masahiro Yamaguchi, Toshiki Uchihara, Saburo Yagishita, Hiroshi Ohizumi …

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(28) 21736-21749, Jul, 2010 Peer-reviewed
14-3-3 Proteins and Spinocerebellar Ataxia Type 1: from Molecular Interaction to Human Neuropathology

Takahiko Umahara, Toshiki Uchihara

CEREBELLUM, 9(2) 183-189, Jun, 2010 Peer-reviewed
Pathological study of pseudohypertrophy of the inferior olivary nucleus

Katsuhiko Ogawa, Tomohiko Mizutani, Kenji Uehara, Masayuki Minami, Yoshio Suzuki, Toshiki Uchihara

NEUROPATHOLOGY, 30(1) 15-23, Feb, 2010 Peer-reviewed
Sialidosis type I carrying V217M/G243R mutations in lysosomal sialidase: an autopsy study demonstrating terminal sialic acid in lysosomal lamellar inclusions and cerebellar dysplasia

Toshiki Uchihara, Ken-ichi Ohashi, Masanobu Kitagawa, Morito Kurata, Ayako Nakamura, Katsuiku Hirokawa, Tsutomu Kasuga, Takayoshi Kobayashi

ACTA NEUROPATHOLOGICA, 119(1) 135-145, Jan, 2010 Peer-reviewed
Presenilin-1 Holoprotein is an Interacting Partner of Sarco Endoplasmic Reticulum Calcium-ATPase and Confers Resistance to Endoplasmic Reticulum Stress

Haifeng Jin, Nobuo Sanjo, Toshiki Uchihara, Kazuhiko Watabe, Peter St George-Hyslop, Paul E. Fraser, Hidehiro Mizusawa

JOURNAL OF ALZHEIMERS DISEASE, 20(1) 261-273, 2010 Peer-reviewed
Depletion or Preservation of Cardiac Sympathetic Nerve - An Autopsy-Verified Contrast in Two Cases of Alzheimer's Disease with or without Lewy Bodies

Shuta Toru, Toshiki Uchihara, Makoto Takahashi, Kazuaki Ichihara, Takashi Endo, Morito Kurata, Masanobu Kitagawa, Katsuiku Hirokawa, Takayoshi Kobayashi

EUROPEAN NEUROLOGY, 64(3) 129-133, 2010 Peer-reviewed
Intractable hiccup caused by medulla oblongata lesions: A study of an autopsy patient with possible neuromyelitis optica

Zen Kobayashi, Kuniaki Tsuchiya, Toshiki Uchihara, Ayako Nakamura, Chie Haga, Osamu Yokota, Hideki Ishizu, Kazuhiro Taki, Tetsuaki Arai, Haruhiko Akiyama …

JOURNAL OF THE NEUROLOGICAL SCIENCES, 285(1-2) 241-245, Oct, 2009 Peer-reviewed
Selective Nuclear Shrinkage of Oligodendrocytes Lacking Glial Cytoplasmic Inclusions in Multiple System Atrophy: A 3-Dimensional Volumetric Study

Naoto Uyama, Toshiki Uchihara, Yoko Mochizuki, Ayako Nakamura, Ryosuke Takahashi, Toshio Mizutani

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 68(10) 1084-1091, Oct, 2009 Peer-reviewed
Selective Deposition of 4-Repeat Tau in Cerebral Infarcts

Kazuaki Ichihara, Toshiki Uchihara, Ayako Nakamura, Yoshio Suzuki, Tomohiko Mizutani

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 68(9) 1029-1036, Sep, 2009 Peer-reviewed
Isoform-dependent immunolocalization of 14-3-3 proteins in developing rat cerebellum

Takahiko Umahara, Toshiki Uchihara, Ayako Nakamura, Toshihiko Iwamoto

BRAIN RESEARCH, 1253 15-26, Feb, 2009 Peer-reviewed

Misc.

Angiotensin-converting enzyme (ACE)

内原俊記

Japanese journal of clinical medicine, 66 83-89, Jan, 2008
Decreased cardiac uptake of MIBG due to cardiac sympathetic denervation in Lewy body disease

ORIMO Satoshi, AMINO Takeshi, KOJO Tohru, UCHIHARA Toshiki, TAKAHASHI Atsushi, WAKABAYASHI Koichi, TAKAHASHI Hitoshi

自律神経 = The Autonomic nervous system, 42(3) 233-238, Jun 15, 2005
A useful marker for differential diagnosis of Parkinson's disease - MIBG myocardial scintigraphy

Satoshi Orimo, Takeshi Amino, Eisuke Ozawa, Tohru Kojo, Toshiki Uchihara, Atsushi Takahashi, Kuniaki Tsuchiya, Koichi Wakabayashi, Hitoshi Takahashi

Clinical Neurology, 44(11) 827-829, Nov, 2004
封入体の神経病理--蛋白沈着の疾患特徴的様式と萎縮・変性との関係 (特集神経病理:最前線)

内原俊記

神経研究の進歩, 48(3) 334-345, Jun, 2004
脊髄小脳変性症の小脳Purkinje細胞におけるPML蛋白の役割

児矢野繁, 黒岩義之, 柳下三郎, 内原俊記, 岩淵潔

Neuropathology : official journal the Japanese Society of Neuropathology, 23, May 1, 2003
筋ジストロフィー症の大脳におけるaquaporin-4の発現

青木和子, 内原俊記, 林雅晴, 中村綾子, 水谷俊雄, 若山吉弘

Neuropathology : official journal the Japanese Society of Neuropathology, 23, May 1, 2003
Marie失調症の再評価 : サルペトリエール病院で臨床病理診断された1剖検例を中心に

岩淵潔, 内原俊記, DUYCKAERTS Charles, 柳下三郎, 岩田誠, HAUW Jean-Jacques

Neuropathology : official journal the Japanese Society of Neuropathology, 23, May 1, 2003
三重免疫蛍光染色したcotton wool plaqueの三次元再構築像の観察

内原俊記, 中村綾子, 中山宏, 有馬邦正, 石塚典生, 森啓, 水嶋節雄

Neuropathology : official journal the Japanese Society of Neuropathology, 23, May 1, 2003
多系統萎縮症のグリア細胞体内封入体におけるTau-2免疫染色の界面活性剤による影響

渋谷克彦, 内原俊記, 中村綾子, 石山宮子, 山岡恵子, 柳下三郎, 岩淵潔, 小阪憲司

Neuropathology : official journal the Japanese Society of Neuropathology, 22, May 1, 2002
CAG repeat病における核内封入体の役割 : SCA2, SCA3, DRPLA橋核神経細胞における定量的検討

内原俊記, 岩淵潔, 船田信顕, 柳下三郎

Neuropathology : official journal the Japanese Society of Neuropathology, 22, May 1, 2002
Thiazin Redを用いたGlial Cytophasmic Inclusionの繊維形成状態の検討

坂本昌己, 内原俊記, 中村綾子, 水谷俊雄, 水澤英洋

Neuropathology : official journal the Japanese Society of Neuropathology, 22 138-138, May 1, 2002
同種一次抗体を用いた免疫(CARD)二重染色法の試み : Cotton wool plaque内外のAβ40, Aβ42エピトープの観察

中村綾子, 内原俊記, 中山宏, 有馬邦正, 森啓, 水嶋節雄

Neuropathology : official journal the Japanese Society of Neuropathology, 22, May 1, 2002
ラット脳におけるataxin-1結合蛋白LANPの局在の再検討

児矢野繁, 内原俊記, 岩淵潔, 柳下三郎, 宋時栄, 田岡万悟

Neuropathology : official journal the Japanese Society of Neuropathology, 22, May 1, 2002
ポリグルタミン病における核内封入体形成過程、特にPMLとの関係

高橋純子, 藤ヶ崎浩人, 内原俊記, 岩淵潔, 田中順一, HAMID El-Hachimi Kahrid, AMALIA Bruni, YVON Trottier, HUGUES de The, JEAN-JACQUES Haw …

Neuropathology : official journal the Japanese Society of Neuropathology, 22, May 1, 2002
ポリグルタミン蛋白は Neuronal intranuclear hyaline inclusion disease の封入体内へ移行する : 3 剖検例の検討

高橋純子, 福田隆浩, 田中順一, 船田信顕, 新井公人, 服部孝道, 中村綾子, 藤ヶ崎浩人, 内原俊記

Neuropathology : official journal the Japanese Society of Neuropathology, 20, Jun 1, 2000
ボリグルタミン蛋白の核内封入体への非特異的移行 : 三重免疫蛍光染色による検討

内原俊記, 中村綾子, 藤ヶ崎浩人, 児矢野繁, 柳下三郎, 岩淵潔

Neuropathology : official journal the Japanese Society of Neuropathology, 20, Jun 1, 2000
SCA2 剖検脳における ataxin-2 および ataxin binding protein の局在

児矢野繁, 内原俊記, 岩淵潔, 柳下三郎, 黒岩義之, 柴田弘紀, PULST Stefan-M

Neuropathology : official journal the Japanese Society of Neuropathology, 20 117-117, Jun 1, 2000
Marinesco 小体形成における polyglutamine protein の関与

藤ヶ崎浩人, 内原俊記, 高橋純子, 松下央, 中村綾子, 児矢野繁, 岩淵潔, 柳下三郎, 平井俊策, 水澤英洋

Neuropathology : official journal the Japanese Society of Neuropathology, 20 120-120, Jun 1, 2000
筋緊張性ジストロフィー症の側頭葉前内側部白質病変

熊田聡子, 林雅晴, 菊地悦子, 伊藤昌弘, 内原俊記, 小田雅也, 水谷俊雄

Neuropathology : official journal the Japanese Society of Neuropathology, 20, Jun 1, 2000
Machado-Joseph病原因遺伝子翻訳産物ataxin-3の細胞内局在

藤ヶ崎浩人, 内原俊記, 中村綾子, 児矢野繁, 岩淵潔, 柳下三郎, 巻淵隆夫, 石川欽也, 田邊勉, 水澤英洋

Neuropathology : official journal the Japanese Society of Neuropathology, 19, Jun 3, 1999