MISC

1998年3月

Apoptotic cell death induced by physarumin (hemagglutinin from myxomycete, Physarum polycephalum)

BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • C Numata
  • ,
  • M Yokota
  • ,
  • M Hosono
  • ,
  • Y Ogawa
  • ,
  • T Suzuki
  • ,
  • Y Takayanagi
  • ,
  • K Nitta

21
3
開始ページ
214
終了ページ
218
記述言語
英語
掲載種別
DOI
10.1248/bpb.21.214
出版者・発行元
PHARMACEUTICAL SOC JAPAN

Physarumin, a carbohydrate-binding protein (hemagglutinin or lectin), was isolated front the plasmodium of Physarum polycephalum. Physarumin agglutinated not only several species of erythrocytes but also tumor cells such as AH109A ascites hepatoma cells, sarcoma 180 ascites cells and mouse leukemia P388 cell lines. Physarumin had tumor cell growth-inhibitory activity, and induced the apoptosis of P388 cell lines. Physarumin-induced apoptosis required binding to a 68 kDa counter-receptor on the P388 cell surface. Since the agglutinating and antiproliferative activities of physarumin were inhibited by asialofetuin and thyroglobulin, respectively, it is suggested that physarumin reacts with the galactose moiety of carbohydrate chains of physarumin receptor.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1248/bpb.21.214
CiNii Articles
http://ci.nii.ac.jp/naid/110003639339
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9556147
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000072630100005&DestApp=WOS_CPL