MISC

1999年4月

Hot water extract of bark of Nikko maple (Acer nikoense) induces apoptosis in leukemia cells

BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • K Nitta
  • ,
  • Y Ogawa
  • ,
  • F Negishi
  • ,
  • T Takahashi
  • ,
  • A Ito
  • ,
  • M Hosono
  • ,
  • Y Takayanagi

22
4
開始ページ
378
終了ページ
381
記述言語
英語
掲載種別
DOI
10.1248/bpb.22.378
出版者・発行元
PHARMACEUTICAL SOC JAPAN

In screening for antitumor constituents in traditional crude drugs, we used three cultured cell lines: mouse leukemia P388 cells, doxorubicin-resistant P388 cells and leczyme (catalytic lectin)-resistant P388 cells. The hot water extract (HWE) of the bark of Nikko maple (Acer nikoense) showed concentration-dependent inhibitory effects on the growth of these three cell lines. DNA fragmentation and morphological changes, accompanied by condensed and fragmented nuclei, were observed in the leukemia cell lines cultured with HWE of the bark of Nikko maple, Treatment with this HWE increased the expression of sialylated glycoconjugates on the apoptotic cells, These results suggest that HWE induces cell death via apoptosis in vitro.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1248/bpb.22.378
CiNii Articles
http://ci.nii.ac.jp/naid/110003639673
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10328557
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000079793300008&DestApp=WOS_CPL