論文

査読有り 国際誌
2018年10月21日

Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells.

Molecules (Basel, Switzerland)
  • Takeo Tatsuta
  • ,
  • Shoko Sato
  • ,
  • Toshiyuki Sato
  • ,
  • Shigeki Sugawara
  • ,
  • Tsuneyoshi Suzuki
  • ,
  • Akiyoshi Hara
  • ,
  • Masahiro Hosono

23
10
記述言語
英語
掲載種別
DOI
10.3390/molecules23102714

Sialic acid-binding lectin from Rana catesbeiana eggs (cSBL) is a multifunctional protein that has lectin and ribonuclease activity. In this study, the anti-tumor activities of cSBL were assessed using a panel of breast cancer cell lines. cSBL suppressed the cell growth of all cancer cell lines tested here at a concentration that is less toxic, or not toxic at all, to normal cells. The growth suppressive effect was attributed to the cancer-selective induction of apoptosis. We assessed the expressions of several key molecules associated with the breast cancer phenotype after cSBL treatment by western blotting. cSBL decreased the expression level of estrogen receptor (ER) α, while it increased the phosphorylation level of p38 mitogen-activated protein kinase (MAPK). cSBL also suppressed the expression of the progesterone receptor (PgR) and human epidermal growth factor receptor type 2 (HER2). Furthermore, it was revealed that cSBL decreases the expression of the epidermal growth factor receptor (EGFR/HER1) in triple-negative breast cancer cells. These results indicate that cSBL induces apoptosis with decreasing ErbB family proteins and may have great potential for breast cancer chemotherapy, particularly in triple-negative phenotype cells.

リンク情報
DOI
https://doi.org/10.3390/molecules23102714
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30347895
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222625