論文

査読有り 国際誌
2017年2月24日

Lissoclibadin 1, a Polysulfur Aromatic Alkaloid from the Indonesian Ascidian Lissoclinum cf. badium, Induces Caspase-Dependent Apoptosis in Human Colon Cancer Cells and Suppresses Tumor Growth in Nude Mice.

Journal of natural products
  • Takeo Tatsuta
  • ,
  • Masahiro Hosono
  • ,
  • Henki Rotinsulu
  • ,
  • Defny S Wewengkang
  • ,
  • Deiske A Sumilat
  • ,
  • Michio Namikoshi
  • ,
  • Hiroyuki Yamazaki

80
2
開始ページ
499
終了ページ
502
記述言語
英語
掲載種別
DOI
10.1021/acs.jnatprod.6b01051

Lissoclibadins, polysulfur aromatic alkaloids, were isolated from the Indonesian ascidian Lissoclinum cf. badium. Lissoclibadins 1 (1), 3 (2), 4 (3), 7 (4), 8 (5), and 14 (6) inhibited the growth of four human solid cancer cell lines: HCT-15 (colon adenocarcinoma), HeLa-S3 (cervix adenocarcinoma), MCF-7 (breast adenocarcinoma), and NCI-H28 (mesothelioma). Lissoclibadin 1 (1) exerted the most potent cytotoxic effects in vitro and mainly promoted apoptosis through an intrinsic pathway with the activation of a caspase-dependent pathway in HCT-15 cells. In vivo studies demonstrated that 1 suppressed tumor growth in nude mice carrying HCT-15 cells without significant secondary adverse effects. In conclusion, the results obtained in the present study demonstrate that 1 has potential as a chemotherapeutic candidate for preclinical investigations.

リンク情報
DOI
https://doi.org/10.1021/acs.jnatprod.6b01051
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28181805