May, 2018 - Mar, 2023

アプタマー情報をベースにした低分子医薬品創製プラットフォームの構築

国立研究開発法人日本医療研究開発機構創薬基盤推進研究事業

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Papers

DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

Hidekazu Hoshino, Yuuya Kasahara, Masayasu Kuwahara, Satoshi Obika

Journal of the American Chemical Society, 142(51) 21530-21537, Dec 23, 2020 Peer-reviewed
Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide

Keisuke Tanaka, Takumi Okuda, Yuuya Kasahara, Satoshi Obika

Molecular Therapy - Nucleic Acids, 23 440-449, Nov, 2020 Peer-reviewedCorresponding author

Development of anti-IL-6R aptamers using base-modified nucleic acid

Yuuya Kasahara, Yoko Senga, Kenta Ishida, Takumi Okuda, Chioko Nagao, Mayumi Niiyama, Haruhiko Kamada, Kenji Mizuguchi, Satoshi Obika

Aug 2, 2022
Enzymatic synthesis of 2′- or 5′-modified nucleic acid derivatives by polymerase mutants

Kenta Ishida, Yuuya Kasahara, Hidekazu Hoshino, Satoshi Obika

Aug 1, 2022