論文

査読有り
2001年8月

Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum

EUROPEAN SPINE JOURNAL
  • T Nakase
  • ,
  • K Ariga
  • ,
  • K Yonenobu
  • ,
  • N Tsumaki
  • ,
  • FP Luyten
  • ,
  • Y Mukai
  • ,
  • Sato, I
  • ,
  • H Yoshikawa

10
4
開始ページ
289
終了ページ
294
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s005860100307
出版者・発行元
SPRINGER-VERLAG

Localization and expression of cartilage-derived morphogenetic protein (CDMP)-1 in tissues at the site of ossification of the ligamentum flavum (OLF) were examined by immunohistochemistry and in situ hybridization. The CDMP-1 protein and messenger ribonucleic acid (mRNA) were localized in spindle-shaped cells and chondrocytes in the OLF tissues. CDMP-1 was not detected in cells in non-ossified sites. These data indicate that CDMP-1 is locally activated and localized in spindle-shaped cells and chondrocytes at the site of OLF. Given the previously reported promoting action of CDMP-1 for chondrogenesis, the current results suggest that CDMP-1 may be involved in the progression of OLF, leading to the narrowing of spinal canal and thus causing severe clinical manifestations.

リンク情報
DOI
https://doi.org/10.1007/s005860100307
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11563613
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000170602500004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s005860100307
  • ISSN : 0940-6719
  • PubMed ID : 11563613
  • Web of Science ID : WOS:000170602500004

エクスポート
BibTeX RIS