2001年8月
Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum
EUROPEAN SPINE JOURNAL
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- 巻
- 10
- 号
- 4
- 開始ページ
- 289
- 終了ページ
- 294
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s005860100307
- 出版者・発行元
- SPRINGER-VERLAG
Localization and expression of cartilage-derived morphogenetic protein (CDMP)-1 in tissues at the site of ossification of the ligamentum flavum (OLF) were examined by immunohistochemistry and in situ hybridization. The CDMP-1 protein and messenger ribonucleic acid (mRNA) were localized in spindle-shaped cells and chondrocytes in the OLF tissues. CDMP-1 was not detected in cells in non-ossified sites. These data indicate that CDMP-1 is locally activated and localized in spindle-shaped cells and chondrocytes at the site of OLF. Given the previously reported promoting action of CDMP-1 for chondrogenesis, the current results suggest that CDMP-1 may be involved in the progression of OLF, leading to the narrowing of spinal canal and thus causing severe clinical manifestations.
- リンク情報
- ID情報
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- DOI : 10.1007/s005860100307
- ISSN : 0940-6719
- PubMed ID : 11563613
- Web of Science ID : WOS:000170602500004