論文

査読有り
2007年

The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis

JOURNAL OF ENDOTOXIN RESEARCH
  • Masahiro Tanaka
  • ,
  • Itaru Yanagihara
  • ,
  • Hitoshi Takahashi
  • ,
  • Mitsuhide Hamaguchi
  • ,
  • Kumiko Nakahira
  • ,
  • Ikuhiro Sakata

13
1
開始ページ
35
終了ページ
38
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0968051907078607
出版者・発行元
SAGE PUBLICATIONS LTD

An excessive accumulation of anandamide (N-archidonoylethanolamine, AEA) is associated with septic shock. Results of previous studies have suggested that mRNA coding for the AEA degrading enzyme fatty acid amide hydrolase (FAAH), which converts AEA into arachidonic acid and ethanolamine, might be down-regulated in septic shock. We used real-time reverse transcription PCR assays to measure relative FAAH mRNA concentrations in the whole blood of 30 healthy donors and eight sepsis patients to ascertain whether such down-regulation takes place. Our results suggest that concentrations of FAAH mRNA in male and female samples from healthy donors are similar, but that concentrations are significantly lower in sepsis patients. These findings indicate that mRNA expression of FAAH in human whole blood correlates with sepsis, and may bi an interesting biomarker for predicting the onset of septic shock.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1177/0968051907078607
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17621544
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000248083500005&DestApp=WOS_CPL

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