Ryoko Ihara

Profile Information

Affiliation: 助教, 神経病理学, 東京大学大学院医学系研究科

Degree: 博士(医学)

J-GLOBAL ID: 201101011301320602
researchmap Member ID: B000004851

アルツハイマー病の研究をしています。

Research Interests

Research Areas

Research History

Sep, 2020 - Present

Chief Physician (MD, PhD), Department of Neurology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Apr, 2019 - Aug, 2020

Assistant Professor, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo
Jul, 2017 - Mar, 2019

Graduate School of Medicine, The University of Tokyo
Jan, 2017 - Jun, 2017

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 2015 - Dec, 2016

Visiting Scholar, Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University in St. Louis
Apr, 2012 - Mar, 2015

Faculty of Medicine University Hospital, The University of Tokyo
Oct, 2011 - Mar, 2012

神経内科, 東京共済病院
Apr, 2011 - Sep, 2011

Neuroscience, Graduate School of Medicine, The University of Tokyo
Apr, 2007 - Mar, 2011

Neuroscience, Graduate School of Medicine, The University of Tokyo
Apr, 2006 - Mar, 2007

神経内科専修医, 横浜労災病院
Jun, 2004 - Mar, 2006

非常勤医員, 東京大学医学部神経内科
Jun, 2003 - May, 2004

内科研修医, 関東中央病院
May, 2002 - May, 2003

内科研修医, 東京大学医学部付属病院

Education

Apr, 2007 - Mar, 2011

脳神経医学専攻, 医学系研究科, 東京大学大学院
Apr, 1996 - Mar, 2002

School of Medicine, Faculty of Medicine, The University of Tokyo

Papers

Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis.

Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Atsushi Iwata, Takeshi Ikeuchi, Takeshi Iwatsubo

Journal of community genetics, Jan 16, 2024
APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy

Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, Takeshi Iwatsubo

Frontiers in Dementia, 2, Jan 15, 2024
本邦におけるAPOE遺伝子検査についての医療機関によるウェブ広告の実態調査

佐藤謙一郎, 新美芳樹, 井原涼子, 岩田淳, 池内健, 岩坪威

Dementia Japan, 37(4) 689-689, Oct, 2023
Detailed Assessment of 18F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome

Kenji Ishibashi, Masanori Kurihara, Ryoko Ihara, Mana Higashihara, Atsushi Iwata, Kenji Ishii

Clinical Nuclear Medicine, 48(10) 841-846, Sep 2, 2023
High sensitivity of asymmetric 18F-THK5351 PET abnormality in patients with corticobasal syndrome.

Masanori Kurihara, Kenji Ishibashi, Tomoyasu Matsubara, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Masashi Kameyama, Aya Midori Tokumaru, Katsuhiko Takeda, Yasushi Nishina …

Scientific reports, 13(1) 12147-12147, Jul 27, 2023
A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol.

Takashi Moritoyo, Naoko Nishimura, Keiko Hasegawa, Shinya Ishii, Kenji Kirihara, Munenori Takata, Akiko Kishi Svensson, Yumi Umeda-Kameyama, Shuichi Kawarasaki, Ryoko Ihara …

British journal of clinical pharmacology, 89(6) 1809-1819, Jun, 2023
Correlations between cerebrospinal fluid homovanillic acid and dopamine transporter SPECT in degenerative parkinsonian syndromes

Ryoji Goto, Masanori Kurihara, Masashi Kameyama, Hiroki Komatsu, Masashi Higashino, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Tomoyasu Matsubara …

Journal of Neural Transmission, Mar 4, 2023
CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease

Masanori Kurihara, Hiroki Komatsu, Renpei Sengoku, Mari Shibukawa, Satoru Morimoto, Tomoyasu Matsubara, Akira Arakawa, Makoto Orita, Kenji Ishibashi, Akihiko Mitsutake …

Neurology, 10.1212/WNL.0000000000201647-10.1212/WNL.0000000000201647, Dec 14, 2022 Peer-reviewed
Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid.

Kensaku Kasuga, Masataka Kikuchi, Tamao Tsukie, Kazushi Suzuki, Ryoko Ihara, Atsushi Iwata, Norikazu Hara, Akinori Miyashita, Ryozo Kuwano, Takeshi Iwatsubo …

BMJ neurology open, 4(2) e000321, 2022
Efficacy and Cost-effectiveness of Promotion Methods to Recruit Participants to an Online Screening Registry for Alzheimer Disease Prevention Trials: Observational Study.

Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Tatsushi Toda, Atsushi Iwata, Takeshi Iwatsubo

Journal of medical Internet research, 23(7) e26284, Jul 22, 2021
A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer’s Disease

M. Senda, K. Ishii, K. Ito, T. Ikeuchi, H. Matsuda, T. Iwatsubo, A. Iwata, R. Ihara, K. Suzuki, K. Kasuga …

The Journal Of Prevention of Alzheimer's Disease, 8(4) 1-8, 2021
Cohort-Specific Optimization of Models Predicting Preclinical Alzheimer’s Disease, to Enhance Screening Performance in the Middle of Preclinical Alzheimer’s Disease Clinical Studies

K. Sato, T. Mano, R. Ihara, K. Suzuki, Y. Niimi, T. Toda, T. Iwatsubo, A. Iwata

The Journal Of Prevention of Alzheimer's Disease, 8(4) 1-10, 2021
Predicting amyloid risk by machine learning algorithms based on the A4 screen data: Application to the Japanese Trial-Ready Cohort study.

Kenichiro Sato, Ryoko Ihara, Kazushi Suzuki, Yoshiki Niimi, Tatsushi Toda, Gustavo Jimenez-Maggiora, Oliver Langford, Michael C Donohue, Rema Raman, Paul S Aisen …

Alzheimer's & dementia (New York, N. Y.), 7(1) e12135, 2021
Gait improvement after levofloxacin administration in a progressive supranuclear palsy patient.

Masanori Kurihara, Kenta Orimo, Tatsuo Mano, Ryoji Miyano, Aya Kamisawa Sato, Kenichiro Sato, Ryoko Ihara, Toshihiro Hayashi, Tatsushi Toda

Clinical parkinsonism & related disorders, 3 100080-100080, 2020
Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease.

Kazushi Suzuki, Akihiro Hirakawa, Ryoko Ihara, Atsushi Iwata, Kenji Ishii, Takeshi Ikeuchi, Chung-Kai Sun, Michael Donohue, Takeshi Iwatsubo

Alzheimer's & dementia (New York, N. Y.), 6(1) e12007, 2020 Peer-reviewed
Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis.

Kenichiro Sato, Tatsuo Mano, Hiroshi Matsuda, Michio Senda, Ryoko Ihara, Kazushi Suzuki, Hiroyuki Arai, Kenji Ishii, Kengo Ito, Takeshi Ikeuchi …

NeuroImage. Clinical, 24 101957-101957, 2019 Peer-reviewed
Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer's Disease in the Japanese Alzheimer's Disease Neuroimaging Initiative.

Kenichiro Sato, Tatsuo Mano, Ryoko Ihara, Kazushi Suzuki, Naoki Tomita, Hiroyuki Arai, Kenji Ishii, Michio Senda, Kengo Ito, Takeshi Ikeuchi …

Journal of Alzheimer's disease : JAD, 68(2) 777-788, 2019 Peer-reviewed
Identification of prognostic factors to predict cognitive decline of patients with early Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative study.

Takuya Yagi, Michio Kanekiyo, Junichi Ito, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, Takeshi Iwatsubo, Ken Aoshima

Alzheimer's & dementia (New York, N. Y.), 5 364-373, 2019 Peer-reviewed
Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort

Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T, Japanese Alzheimer's, Disease Neuroimaging Initiative

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4 645-651, Nov, 2018 Peer-reviewed
Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease.

Ihara R, Vincent BD, Baxter MR, Franklin EE, Hassenstab JJ, Xiong C, Morris JC, Cairns NJ

Annals of neurology, 84(5) 741-753, Sep, 2018 Peer-reviewed

Misc.

【認知症のゲノム医療】DIAN/DIAN-TU,その日本からの参加の歩み

井原涼子

Dementia Japan, 37(2) 273-279, Apr, 2023
タウを標的とする疾患修飾薬の開発状況—Recent updates on the development of disease modifying therapies targeting tau—特集認知症の薬物治療

井原涼子, 岩田淳

臨床精神薬理 = Japanese journal of clinical psychopharmacology, 26(2) 149-154, Feb, 2023
【認知症の包括的なリスク低減に向けて】疾患修飾薬による認知症の超早期治療

井原涼子, 岩田淳

Progress in Medicine, 43(1) 67-70, Jan, 2023
臨床研究と診療におけるバイオマーカー結果開示の実際と課題—Experiences and challenges in disclosing Alzheimer's disease biomarker results in clinical research and clinical practice—特集バイオマーカー結果開示をめぐる諸問題

井原涼子

Dementia Japan : 日本認知症学会誌 / 日本認知症学会誌編集委員会編, 37(1) 47-53, Jan, 2023
遺族への解剖診断報告は家族支援となるかブレインバンク事前登録の活動報告

小幡真希, 原愛徒, 荒川晶, 織田麻琴, 松原知康, 栗原正典, 井原涼子, 東原真奈, 仁科裕史, 金丸和富 …

老年精神医学雑誌, 33(増刊II) 375-375, Nov, 2022
【エキスパートがお答えします!日常臨床のあるあるの疑問】(第10章)神経もの忘れを訴える患者にコリンエステラーゼ阻害薬を処方したのですが,もの忘れがよくなりません.どうしたらよいでしょうか?

井原涼子

内科, 130(3) 662-665, Sep, 2022
【神経疾患とゲノム医療】個別病態・疾患のゲノム医療アルツハイマー病

井原涼子, 岩田淳

Clinical Neuroscience, 40(9) 1121-1124, Sep, 2022
Quality control and quality assurance of cognitive data in dementia clinical studies and trials

井原涼子

Dementia Japan, 36(3) 453-459, Sep, 2022
医学検査のあゆみ認知症の検査の進歩

井原涼子, 岩田淳

Modern Media, 68(8) 354-358, Aug, 2022
【"認知症+併存疾患" アプローチの最前線】代表的な認知症 Alzheimer型認知症

井原涼子, 岩田淳

内科, 129(6) 1261-1264, Jun, 2022
神経疾患の新しい治療アルツハイマー病

井原涼子, 岩田淳

Clinical Neuroscience, 40(5) 682-684, May, 2022
【認知症を取り巻く現状:バイオマーカー、根本治療薬ってなに?】認知症診療の基本診断、治療、BPSD対処の基本 Alzheimer病

井原涼子

診断と治療, 110(5) 555-561, May, 2022
認知機能評価の問題点と将来臨床研究における認知機能評価の品質管理

井原涼子

Dementia Japan, 35(4) 578-578, Oct, 2021
認知症のゲノム医療 DIAN/DIAN-TU

井原涼子

Dementia Japan, 35(4) 586-586, Oct, 2021
バイオマーカー結果開示をめぐる諸問題臨床研究と診療におけるバイオマーカー結果開示の実際と課題

井原涼子

Dementia Japan, 35(4) 590-590, Oct, 2021
【認知症の疾患概念について考える;歴史的事項から将来まで】アルツハイマー病概念の成立と変遷

井原涼子, 岩田淳

老年精神医学雑誌, 32(10) 1040-1045, Oct, 2021
DIAN Japan study: moving forward to genome-based medicine

池内健, 井原涼子

Dementia Japan, 35(3) 408-417, Sep, 2021
【意外と知られていない!? 自科の常識・他科の非常識】(第8章)神経抗認知症薬は必ずしも「記憶」を改善させない

井原涼子

内科, 128(3) 631-633, Sep, 2021
【内科疾患の診断基準・病型分類・重症度】(第7章)神経・筋認知症

井原涼子

内科, 127(4) 818-820, Apr, 2021
【健康診断と予防医学】予防医学をめぐる最新の話題認知症の早期発見と予防

井原涼子, 岩田淳

Medical Practice, 38(2) 231-234, Feb, 2021

Professional Memberships

Research Projects

心房細動アブレーションによる洞調律化が認知機能に与える効果の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

宮崎晋介, 井原涼子, 西田陽一郎

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Professional Memberships

Research Projects

Menu

Coauthors