論文

査読有り
2014年6月

Role of oocyte-derived paracrine factors in follicular development

ANIMAL SCIENCE JOURNAL
  • Chihiro Emori
  • ,
  • Koji Sugiura

85
6
開始ページ
627
終了ページ
633
記述言語
英語
掲載種別
DOI
10.1111/asj.12200
出版者・発行元
WILEY-BLACKWELL

Mammalian oocytes secrete transforming growth factor (TGF-) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs). These oocyte-derived paracrine factors (ODPFs) play essential roles in regulating the differentiation and function of somatic granulosa cells as well as the development of ovarian follicles. In addition to the importance of individual ODPFs, emerging evidence suggests that the interaction of ODPF signals with other intra-follicular signals, such as estrogen, is critical for folliculogenesis. In this review, we will discuss the current understanding of the role of ODPFs in follicular development with an emphasis on their interaction with estrogen signaling in regulation of the differentiation and function of granulosa cells.

Web of Science ® 被引用回数 : 39

リンク情報
DOI
https://doi.org/10.1111/asj.12200
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24717179
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000337521300002&DestApp=WOS_CPL