2010年4月8日
Complexity in influenza virus targeted drug design: interaction with human sialidases.
Journal of medicinal chemistry
- 巻
- 53
- 号
- 7
- 開始ページ
- 2998
- 終了ページ
- 3002
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/jm100078r
- 出版者・発行元
- AMER CHEMICAL SOC
With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.
- リンク情報
- ID情報
-
- DOI : 10.1021/jm100078r
- ISSN : 0022-2623
- eISSN : 1520-4804
- PubMed ID : 20222714
- Web of Science ID : WOS:000276096300027