論文

査読有り 国際誌
2018年3月27日

Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity.

Cell reports
  • Akiko Ueno
  • ,
  • Yoshihiro Omori
  • ,
  • Yuko Sugita
  • ,
  • Satoshi Watanabe
  • ,
  • Taro Chaya
  • ,
  • Takashi Kozuka
  • ,
  • Tetsuo Kon
  • ,
  • Satoyo Yoshida
  • ,
  • Kenji Matsushita
  • ,
  • Ryusuke Kuwahara
  • ,
  • Naoko Kajimura
  • ,
  • Yasushi Okada
  • ,
  • Takahisa Furukawa

22
13
開始ページ
3548
終了ページ
3561
記述言語
英語
掲載種別
DOI
10.1016/j.celrep.2018.03.007

In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells. However, the mechanisms underlying selective synapse formation in the cone photoreceptor pathway remain poorly understood. Here, we found that Lrit1, a leucine-rich transmembrane protein, localizes to the photoreceptor synaptic terminal and regulates the synaptic connection between cone photoreceptors and cone ON-bipolar cells. Lrit1-deficient retinas exhibit an aberrant morphology of cone photoreceptor pedicles, as well as an impairment of signal transmission from cone photoreceptors to cone ON-bipolar cells. Furthermore, we demonstrated that Lrit1 interacts with Frmpd2, a photoreceptor scaffold protein, and with mGluR6, an ON-bipolar cell-specific glutamate receptor. Additionally, Lrit1-null mice showed visual acuity impairments in their optokinetic responses. These results suggest that the Frmpd2-Lrit1-mGluR6 axis regulates selective synapse formation in cone photoreceptors and is essential for normal visual function.

リンク情報
DOI
https://doi.org/10.1016/j.celrep.2018.03.007
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29590622