杜成坤 (Cheng-Kun Du) - マイポータル

基本情報

所属: 国立研究開発法人国立循環器病研究センター心臓生理機能部上級研究員

学位: 医学博士(九州大学)

研究者番号: 90590646
J-GLOBAL ID: 201601001217054915
researchmap会員ID: B000254703

外部リンク

研究キーワード

研究分野

学歴

2003年4月 - 2007年3月

九州大学, 大学院医学研究院分子常態医学専攻

論文

β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat.

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie P C Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley …

Clinical science (London, England : 1979) 135(2) 327-346 2021年1月29日
Beta-blockade Prevents Coronary Macro and Microvascular Dysfunction Induced by a High Salt Diet and Insulin Resistance in the Goto-Kakizaki Rat.

James Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie Pc Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley …

Clinical science (London, England : 1979) 2021年1月12日
β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.

Toshihide Kashihara, Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Shin Kadota, Elena E Wolf, Cheng-Kun Du, Yuji Shiba, Sachio Morimoto, Mitsuhiko Yamada

JACC. Basic to translational science 5(11) 1057-1069 2020年11月
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart

Jason Kar-Sheng Lew, James T. Pearson, Eugene Saw, Hirotsugu Tsuchimochi, Melanie Wei, Nilanjan Ghosh, Cheng-Kun Du, Dong-Yun Zhan, Meihua Jin, Keiji Umetani …

Circulation Research 1384-1400 2020年
Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo.

Sonobe T, Akiyama T, Du CK, Pearson JT.

Physiol Rep. 7(22) 2019年11月査読有り
Ghrelin and vascular protection.

Pearson JT, Shirai M, Sukumaran V, Du CK, Tsuchimochi H, Sonobe T, Waddingham MT, Katare R, Schwenke DO.

Vasc Biol. 1(1) 2019年9月査読有り
Progressive decrease in coronary vascular function associated with Type 2 diabetic heart disease

Rajesh Katare, James T. Pearson, Jason Kar-Sheng Lew, Melanie Wei, Hirotsugu Tsuchimouchi, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Mikiyasu Shirai, Daryl O. Schwenke

Frontiers in Physiology 9 696 2018年6月6日査読有り
Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.

Takuro Arimura, Antoine Muchir, Masayoshi Kuwahara, Sachio Morimoto, Taisuke Ishikawa, Cheng-Kun Du, Dong-Yun Zhan, Shu Nakao, Noboru Machida, Ryo Tanaka …

American journal of physiology. Heart and circulatory physiology 314(6) H1192-H1202-H1202 2018年6月1日査読有り
Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation

Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T. Pearson

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL 205 33-40 2017年7月査読有り
Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion

Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Tadakatsu Inagaki, Toshiaki Shishido, Mikiyasu Shirai, James T. Pearson

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 312(1) H60-H67 2017年1月査読有り
FASUDIL PREVENTS CORONARY MICROVASCULAR ENDOTHELIAL DYSFUNCTION AND CARDIAC CONTRACTILE DYSFUNCTION IN A RAT MODEL OF HYPERTENSIVE DIABETES MORE THAN LOSARTAN

Pearson James, Tsuchimochi Hirotsugu, Inagaki Tadakatsu, Du Cheng-Kun, Zhang Dong-Yun, Schwenke Daryl, Edgley Amanda, Umetani Keiji, Yagi Naoto, Shirai Mikiyasu

JOURNAL OF HYPERTENSION 34 E423-E424 2016年9月査読有り
GSK-3β heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy.

Mohamed RM, Morimoto S, Ibrahim IA, Zhan DY, Du CK, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T

American journal of physiology. Heart and circulatory physiology 310(11) H1808-H1815 2016年6月査読有り
Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion in rats

Tadakatsu Inagaki, Tsuyoshi Akiyama, Cheng-Kun Du, Dong-Yun Zhan, Misa Yoshimoto, Mikiyasu Shirai

FREE RADICAL RESEARCH 50(6) 645-653 2016年査読有り
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

Mark T. Waddingham, Amanda J. Edgley, Alberto Astolfo, Tadakatsu Inagaki, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Hirotsugu Tsuchimochi, Naoto Yagi, Darren J. Kelly …

CARDIOVASCULAR DIABETOLOGY 14 92 2015年7月査読有り
Myocardial interstitial serotonin and its major metabolite, 5-hydroxyindole acetic acid levels determined by microdialysis technique in rat heart

Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Takashi Sonobe, Tadakatsu Inagaki, Mikiyasu Shirai

LIFE SCIENCES 117(1) 33-39 2014年11月査読有り
Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy

Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto, Tsuyoshi Akiyama, Daryl O. Schwenke, Hiroshi Hosoda, Kenji Kangawa, Mikiyasu Shirai

Pharmacology Research and Perspectives 2(5) e00064 2014年10月1日査読有り
In vivo effects of propyl gallate, a novel Ca2+ sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation

Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto

LIFE SCIENCES 109(1) 15-19 2014年7月査読有り
Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats

T. Sonobe, T. Akiyama, C. -K. Du, D. -Y. Zhan, M. Shirai

ACTA PHYSIOLOGICA 210(4) 823-831 2014年4月査読有り
In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice

Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Takashi Sonobe, Hirotsugu Tsuchimochi, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL 176(1-2) 91-94 2013年6月査読有り
Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits

T. Sonobe, T. Akiyama, C. -K. Du, D. -Y. Zhan, M. Shirai

ACTA PHYSIOLOGICA 207(2) 260-268 2013年2月査読有り

もっとみる

MISC

心臓マイクロダイアリシス法の利点.

秋山剛, 清水秀二, 杜成坤, 戦冬雲, 稲垣董克, 吉本光佐, 曽野部崇, 川田徹, ピアソンジェームズ

Circ Cont 38 208-217 2017年
Cardiac Vagal Control in Knock-in Mouse model of Dilated Cardiomyopathy

DongYun Zhan, ChengKun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T. Pearson

CIRCULATION 134 2016年11月
Cardiac Vagal Control in Knock-in Mouse model of Dilated Cardiomyopathy

DongYun Zhan, ChengKun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T. Pearson

CIRCULATION 134 2016年11月
遺伝性拡張型心筋症に対する新規治療法の開発に向けて

戦冬雲, 杜成坤, 森本幸生, 秋山剛, Schwenke Daryl O, 細田洋司, 寒川賢治, 白井幹康, James Person

BIO Clinica 31(6) 647-650 2016年6月招待有り
遺伝性拡張型心筋症に対する新規治療法の開発に向けて.

戦冬雲, 杜成坤, 森本幸生, 秋山剛, Daryl O. Schwenke, 細田洋司, 寒川賢治, 白井幹康, Pearson James

BIO Clinica 31(6) 101-104 2016年
The Treatment Benefit of Ghrelin on a Mouse Model of Inherited Dilated Cardiomyopathy Caused by Troponin Mutation

DongYun Zhan, ChengKun Du, Sachio Morimoto, Tsuyoshi Akiyama, Daryl O. Schwenke, Hiroshi Hosoda, Kenji Kangawa, Mikiyasu Shirai

BIOPHYSICAL JOURNAL 108(2) 596A-596A 2015年1月
Myocardial Interstitial Serotonin and its Major Metabolite, 5-Hydroxyindole Acetic Acid Levels Determined by Microdialysis Technique in vivo Rat Heart

Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Takashi Sonobe, Tadakatsu Inagaki, Mikiyasu Shirai

BIOPHYSICAL JOURNAL 108(2) 595A-596A 2015年1月
Cardiac vagal control in a knock-in mouse of dilated cardiomyopathy with a troponin mutation

Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 193P-193P 2014年
Overexpression of the amino-terminal domain of TRPV2 has the beneficial effect for dilated cardiomyopathy mice with mutation of troponin T

Shinya Kamauchi, Yuko Iwata, Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto, Mikiyasu Shirai, Shigeo Wakabayashi

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 194P-194P 2014年
Myocardial interstitial serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels during ischemia-reperfusion

Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Tadakatsu Inagaki, Mikiyasu Shirai

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 193P-193P 2014年
Effects of ghrelin on survival and cardiac remodeling of dilated cardiomyopathy mice with troponin mutation

Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto, Tsuyoshi Akiyama, Kenji Kangawa, Mikiyasu Shirai

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 161P-161P 2013年
Effects of ghrelin on survival and cardiac remodeling of dilated cardiomyopathy mice with troponin mutation

Du Cheng-Kun, Zhan Dong-Yun, Sachio Morimoto, Tsuyoshi Akiyama, Kenji Kangawa, Mikiyasu Shirai

JOURNAL OF PHYSIOLOGICAL SCIENCES 63 S183-S183 2013年
In vivo assessment of norepinephrine kinetics at cardiac sympathetic nerve ending in the anesthetized mice

Zhan Dong-Yun, Du Cheng-Kun, Tsuyoshi Akiyama, Takashi Sonobe, Mikiyasu Shirai

JOURNAL OF PHYSIOLOGICAL SCIENCES 63 S182-S182 2013年
Comparison of disease phenotypes in mouse models of inherited cardiomyopathy on C57BI/6 and BALB/c backgrounds

Lei Li, Sachio Morimoto, Dong-Yun Zhan, Cheng-Kun Du, Yuan-Yuan Wang, Xue-Li Fan, Tatsuya Yoshihara, Fumi Takahashi, Toshiyuki Sasaguri

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 76P-76P 2012年
Role of brain 5-HT levels in the onset of heart failure in a mouse model of dilated cardiomyopathy

Lei Li, Sachio Morimoto, Dong-Yun Zhan, Yuan-Yuan Wang, Cheng-Kun Du, Xue-Li Fan, Toshiyuki Sasaguri

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 88P-88P 2011年
Effect of propyl gallate, a novel Ca2+sensitizer with antioxidant activity, on cardiac function in mice

Cheng-Kun Du, Daiki Mori, Sachio Morimoto, Dong-Yun Zhan, Toshiyuki Sasaguri

JOURNAL OF PHARMACOLOGICAL SCIENCES 112 245P-245P 2010年
Effect of genetic background on the phenotypic expression of troponin mutation in a knock-in mouse model of dilated cardiomyopathy

Lei Li, Sachio Morimoto, Dong-Yun Zhan, Yuan-Yuan Wang, Cheng-Kun Du, Xue-Li Fan, Toshiyuki Sasaguri

JOURNAL OF PHARMACOLOGICAL SCIENCES 112 196P-196P 2010年
Therapeutic effect of beta-blockers using a mouse model of dilated cardiomyopathy with a troponin mutation

Dong-Yun Zhan, Sachio Morimoto, Cheng-Kun Du, Yuan-Yuan Wang, Qun-Wei Lu, Atsushi Tanaka, Tomomi Ide, Yoshikazu Miwa, Fumi Takahashi, Toshiyuki Sasaguri

JOURNAL OF PHARMACOLOGICAL SCIENCES 112 126P-126P 2010年
CARDIAC-SPECIFIC OVEREXPRESSION OF NCX1.1 MUTANT INDUCES DILATED CARDIOMYOPATHY IN MICE

Satomi Kita, Takuya Iyoda, Satomi Adachi-Akahane, Koichi Fukusaki, Hajime Takamatsu, Toshiaki Sato, Haruaki Nakaya, Cheng-Kun Du, Sachio Morimoto, Yuji Arai …

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 313-313 2009年
Effects of carvedilol and metoprolol on cardiac remodeling and survival of dilated cardiomyopathy mice with troponin mutation

Dong-Yun Zhan, Sachio Morimoto, Cheng-Kun Du, Yuanyuan Wang, Toshiyuki Sasaguri

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 169P-169P 2009年

もっとみる

書籍等出版物

心筋ミオフィラメントCa感受性.

杜成坤, 森本幸生 (担当:共著, 範囲:心不全（第2版）上卷ー最新の基礎・臨床研究の進歩ー)

日本臨牀 2018年12月

所属学協会

共同研究・競争的資金等の研究課題

Influence of non-vascular cells in accelerated coronary aging in diabetes

日本学術振興会科学研究費助成事業基盤研究(B) 2019年4月 - 2023年3月

Pearson James, 土持裕胤, 曽野部崇, 岩田裕子, 杜成坤
肥大型心筋症の病態形成における心筋エネルギー代謝異常の役割の解明と治療薬の検討

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2019年4月 - 2022年3月

杜成坤, 森本幸生
ノックインマウスを用いたヒト遺伝性心筋症の病態形成メカニズム解明と治療薬の検討

日本学術振興会科学研究費補助金基盤研究(C) 2016年4月 - 2019年3月

杜成坤
初期2型糖尿病ラットでの拡張期末の心筋収縮タンパク質分子動態異常の放射光解析

日本学術振興会科学研究費助成事業挑戦的萌芽研究 2016年4月 - 2018年3月

白井幹康, 土持裕胤, Pearson James, 杜成坤, 金美花, 戦冬雲, 稲垣薫克, 八木直人
肥大型心筋症の発症機序解明と治療法開発に関する基礎研究

日本学術振興会科学研究費補助金若手研究(B) 2012年4月 - 2015年3月

杜成坤
中枢神経を標的にした心不全致死病態の治療に関する基礎研究

日本学術振興会科学研究費助成事業挑戦的萌芽研究 2011年 - 2012年

白井幹康, 秋山剛, 土持裕胤, 杜成坤, 森本幸生

杜成坤

基本情報

研究キーワード

研究分野

学歴

論文

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー

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