論文

国際誌
2019年6月28日

Konamycins A and B and Rubromycins CA1 and CA2, Aromatic Polyketides from the Tunicate-Derived Streptomyces hyaluromycini MB-PO13T.

Journal of natural products
  • Enjuro Harunari
  • ,
  • Chiaki Imada
  • ,
  • Yasuhiro Igarashi

82
6
開始ページ
1609
終了ページ
1615
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.jnatprod.9b00107

Four new aromatic polyketides, konamycins A (1) and B (2) and rubromycins CA1 (3) and CA2 (4), were isolated from the culture extract of the tunicate-derived Streptomyces hyaluromycini MB-PO13T. Compounds 1 and 2 possess a benzo[ b]fluorene aglycon modified by C-glycosylation with l-amicetose. Compounds 3 and 4 are the new congeners of rubromycin in which a naphthoquinone and carboxylated isocoumarin are joined through a spiroketal carbon. The structures of these compounds were determined by extensive analysis of 1D and 2D NMR spectroscopic data. Compound 1 showed radical scavenging activity in DPPH and superoxide quenching assays, and 3 and 4 displayed antimicrobial activity against Gram-positive bacteria.

リンク情報
DOI
https://doi.org/10.1021/acs.jnatprod.9b00107
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31181919
ID情報
  • DOI : 10.1021/acs.jnatprod.9b00107
  • PubMed ID : 31181919

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