2014年11月
Water-mediated forces between the nucleotide binding domains generate the power stroke in an ABC transporter
CHEMICAL PHYSICS LETTERS
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 616
- 号
- 開始ページ
- 165
- 終了ページ
- 170
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cplett.2014.10.038
- 出版者・発行元
- ELSEVIER SCIENCE BV
ATP binding cassette proteins shuttle a variety of molecules across cell membranes. The substrate transportation process is initiated by the ATP-driven dimerization of nucleotide binding domains (NBDs). Here, the integral-equation theory of liquids was applied to simulated NBD structures to analyze their dimerization process from the viewpoint of thermodynamics and the water-mediated interaction between the NBDs. It was found that a long-range hydration force of enthalpic origin drives the two NBDs to approach from a large separation. In the subsequent step, the water-mediated attraction of entropic origin brings about a structural adjustment between the two NBDs and their tighter contact. (C) 2014 Elsevier B.V. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.cplett.2014.10.038
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000345397700030&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84908409515&origin=inward
- ID情報
-
- DOI : 10.1016/j.cplett.2014.10.038
- ISSN : 0009-2614
- eISSN : 1873-4448
- SCOPUS ID : 84908409515
- Web of Science ID : WOS:000345397700030