論文

査読有り
2014年11月

Water-mediated forces between the nucleotide binding domains generate the power stroke in an ABC transporter

CHEMICAL PHYSICS LETTERS
  • Tomoka Furukawa-Hagiya
  • ,
  • Norio Yoshida
  • ,
  • Shuntaro Chiba
  • ,
  • Tomohiko Hayashi
  • ,
  • Tadaomi Furuta
  • ,
  • Yoshiro Sohma
  • ,
  • Minoru Sakurai

616
開始ページ
165
終了ページ
170
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cplett.2014.10.038
出版者・発行元
ELSEVIER SCIENCE BV

ATP binding cassette proteins shuttle a variety of molecules across cell membranes. The substrate transportation process is initiated by the ATP-driven dimerization of nucleotide binding domains (NBDs). Here, the integral-equation theory of liquids was applied to simulated NBD structures to analyze their dimerization process from the viewpoint of thermodynamics and the water-mediated interaction between the NBDs. It was found that a long-range hydration force of enthalpic origin drives the two NBDs to approach from a large separation. In the subsequent step, the water-mediated attraction of entropic origin brings about a structural adjustment between the two NBDs and their tighter contact. (C) 2014 Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.cplett.2014.10.038
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000345397700030&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84908409515&origin=inward
ID情報
  • DOI : 10.1016/j.cplett.2014.10.038
  • ISSN : 0009-2614
  • eISSN : 1873-4448
  • SCOPUS ID : 84908409515
  • Web of Science ID : WOS:000345397700030

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