Chihiro Nozaki

Profile Information

Affiliation: 准教授, 理工学術院, 早稲田大学

Degree: 博士(星薬科大学)

Contact information: chihironaoni.waseda.jp
J-GLOBAL ID: 201501076190219498
researchmap Member ID: B000243512

External link: http://www.ohshima.biomed.sci.waseda.ac.jp/major_in_bioscience/m_nozaki.html

My research interest was always based on neuroinflammation and neuronal hypersensitivity under the pathological state.

Currently I'm working on the DFG-funded project "Role of endocannabinoid system on the modulation of migraine", to evaluate if FAAH-CB1 signaling contributes to the modulation of migraine and/or medication overuse headache pain including its gender difference.

Also I'm interested in if endocannabinoid systems will modulate any kind of diseases which induces pain/neuroinflammation such as diabetes, obesity, allergy or Alzheimer's disease, as CB1 signalings involves to the metabolisms while CB2 signalings contributes to the immune systems.

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Associate professor, Faculty of Science and Engineering, Waseda University
Dec, 2019 - Mar, 2020

プロジェクト研究員, 炎症・免疫難病制御部門, 東京理科大学生命医科学研究所
Jan, 2016 - Nov, 2019

DFG Eigene Stelle（Temporary PI）, Institute of Molecular Psychiatry, University of Bonn
Oct, 2011 - Dec, 2015

Postdoctoral Fellow, Institute of Molecular Psychiatry, Uniersity of Bonn
Jul, 2007 - Sep, 2011

Postdoctoral researcher, Medecine translationnelle & Neurogenetique, Institut de génétique et de biologie moléculaire et cellulaire (IGBMC)
Apr, 2006 - Oct, 2006

Research Assistant, Center for Sensory-Motor Interaction, Aalborg University

Education

Awards

2018

Excelent Young Researcher candidate 2018, Japan Society for the Promotion of Science

Chihiro Nozaki
Jan, 2009

Financement de projets impliquant des post-doctorant en France, Fondation pour la Recherche Medicale

Chihiro Nozaki
Aug, 2005

Travel Award, International Narcotic Research Conference (INRC)

Chihiro Nozaki

Papers

Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.

Kosuke Kataoka, Andras Bilkei-Gorzo, Chihiro Nozaki, Akinobu Togo, Keiichiro Nakamura, Keisuke Ohta, Andreas Zimmer, Toru Asahi

Brain research bulletin, 160 40-49, Jul, 2020 Peer-reviewed
CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain.

Elisa Nent, Chihiro Nozaki, Anne-Caroline Schmöle, David Otte, Andreas Zimmer

Scientific reports, 9(1) 7468-7468, May 16, 2019 Peer-reviewed
Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain.

Chihiro Nozaki, Elisa Nent, Andras Bilkei-Gorzo, Andreas Zimmer

Scientific reports, 8(1) 10827-10827, Jul 17, 2018 Peer-reviewedLead author
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.

Chihiro Nozaki, Astrid Markert, Andreas Zimmer

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 25(8) 1388-96, Aug, 2015 Peer-reviewedLead authorCorresponding author
In vivo properties of KNT-127, a novel delta opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice

C. Nozaki, H. Nagase, T. Nemoto, A. Matifas, B. L. Kieffer, C. Gaveriaux-Ruff

BRITISH JOURNAL OF PHARMACOLOGY, 171(23) 5376-5386, Dec, 2014 Peer-reviewedLead authorCorresponding author
δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.

Chihiro Nozaki, Bertrand Le Bourdonnec, David Reiss, Rolf T Windh, Patrick J Little, Roland E Dolle, Brigitte L Kieffer, Claire Gavériaux-Ruff

The Journal of pharmacology and experimental therapeutics, 342(3) 799-807, Sep, 2012 Peer-reviewedLead author
The delta opioid receptor: an evolving target for the treatment of brain disorders.

Amynah A Pradhan, Katia Befort, Chihiro Nozaki, Claire Gavériaux-Ruff, Brigitte L Kieffer

Trends in pharmacological sciences, 32(10) 581-90, Oct, 2011 Peer-reviewedInvited
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.

Chihiro Nozaki, Angela Maria Vergnano, Dominique Filliol, Abdel-Mouttalib Ouagazzal, Anne Le Goff, Stéphanie Carvalho, David Reiss, Claire Gaveriaux-Ruff, Jacques Neyton, Pierre Paoletti …

Nature neuroscience, 14(8) 1017-22, Jul 3, 2011 Peer-reviewedLead author
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

Claire Gaveriaux-Ruff, Chihiro Nozaki, Xavier Nadal, Xavier C Hever, Raphael Weibel, Audrey Matifas, David Reiss, Dominique Filliol, Mohammed A Nassar, John N Wood …

Pain, 152(6) 1238-1248, Jun, 2011 Peer-reviewed
Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

Amynah A A Pradhan, Wendy Walwyn, Chihiro Nozaki, Dominique Filliol, Eric Erbs, Audrey Matifas, Christopher Evans, Brigitte L Kieffer

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(49) 16459-68, Dec 8, 2010 Peer-reviewed
Role of cyclin-dependent kinase 5 in capsaicin-induced cough.

Junzo Kamei, Shun-suke Hayashi, Yoshiki Takahashi, Chihiro Nozaki

European journal of pharmacology, 566(1-3) 181-4, Jul 2, 2007 Peer-reviewed
Involvement of mu1-opioid receptor on oxycodone-induced antinociception in diabetic mice.

Chihiro Nozaki, Junzo Kamei

European journal of pharmacology, 560(2-3) 160-2, Apr 10, 2007 Peer-reviewedLead author
Possible involvement of opioidergic systems in the antinociceptive effect of the selective serotonin reuptake inhibitors in sciatic nerve-injured mice.

Chihiro Nozaki, Junzo Kamei

European journal of pharmacology, 552(1-3) 99-104, Dec 15, 2006 Peer-reviewedLead author
Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy.

Akiyoshi Saitoh, Noritaka Hirose, Mitsuhiko Yamada, Misa Yamada, Chihiro Nozaki, Takuma Oka, Junzo Kamei

Journal of pharmacological sciences, 102(4) 377-86, Dec, 2006 Peer-reviewed
Effect of mexiletine on vincristine-induced painful neuropathy in mice.

Junzo Kamei, Chihiro Nozaki, Akiyoshi Saitoh

European journal of pharmacology, 536(1-2) 123-7, Apr 24, 2006 Peer-reviewedLead author
Characterization of the antinociceptive effects of oxycodone in diabetic mice.

Chihiro Nozaki, Akiyoshi Saitoh, Junzo Kamei

European journal of pharmacology, 535(1-3) 145-51, Mar 27, 2006 Peer-reviewedLead author
Antinociceptive effect of oxycodone in diabetic mice.

Chihiro Nozaki, Akiyoshi Saitoh, Naoya Tamura, Junzo Kamei

European journal of pharmacology, 524(1-3) 75-9, Nov 7, 2005 Peer-reviewedLead author

Misc.

The Use of an Amyloid beta Intracerebroventricular Model to Investigate the Interaction between Alzheimer‘s Disease and Circadian Dysfunction

Lovell Lyndah, Nozaki Chihiro, Tahara Yu, Shibata Shigenobu

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 3-B-SS14-2, Dec, 2022
Involvement of cannabinoid receptor type 2 (CB2) to dendritic cell population on inflammatory and allergic response

Hosoki Haruka, Nozaki Chihiro, Furutani Akiko, Shibata Shigenobu

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 1-B-SS06-5, Dec, 2022 Corresponding author
カンナビノイド受容体が無くなると、我々の身体は一体どうなってしまうのか？

野崎千尋, Andreas Zimmer, 柴田重信

日本臨床薬理学会学術総会抄録集, 43 3-C-S31-2, Dec, 2022 Lead authorCorresponding author
Cellulose rich food induces intestinal disturbance, anxiety-like behavior and amygdalar dopaminergic hyperactivity in mice.

Kaede Ito, Haraguchi Atsushi, Nozaki Chihiro, Shibata Shigenobu

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 3-B-SS13-5, Dec, 2022
Bipolar effect of cannabinoid CB2 receptors to peripheral neuroinflammation

Nozaki Chihiro, Zimmer Andreas, Shibata Shigenobu

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 3-B-O11-2, Dec, 2022 Lead authorCorresponding author
カンナビノイドCB2受容体の持つ二面性：レプチンシグナリングを介した末梢神経炎症調節機構に対する影響を中心に

野崎千尋, Andreas Zimmer, 柴田重信

Neuro2022, Jun, 2022 Peer-reviewedLead authorCorresponding author
Establishment of the novel method to culture primary neurons from aged rodent brain

Yuya Kasai, Nozaki Chihiro, Shibata Shigenobu

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 2-B-P-115, 2022 Corresponding author
Can Cannabidiol affect the peripheral circadian clockin PER2::LUC mice?

Wang Hsiao Hsieh, Nozaki Chihiro, Shibata Shigenobu

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 1-B-SS03-2, 2022 Corresponding author
第26回いかにして欧州でママさんチームリーダーとなったか

野崎千尋

ファルマシア, 57(8) 768-769, 2021 Invited
CB2 receptor deletion on myeloid cells elevates neuropathic pain development in mice

Chihiro Nozaki, Elisa Nen, Andreas Zimmer

50th International Narcotic Research Conference (INRC), Jul, 2019 Lead author
Genetic ablation of CB2 receptors enhances neuropathic pain development via boosted leptin signaling in peripheral nerves

Chihiro Nozaki, Andreas Zimmer

12th Goettingen Meeting of the German Neuroscience Society, Mar, 2017 Lead author
Genetic ablation of CB2 receptors enhances neuropathic pain development via boosted leptin signaling in peripheral nerves

Chihiro Nozaki, Nent Elisa, Markert Astrid, Zimmer Andreas

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S86-S86, Mar, 2017 Peer-reviewedLead author
Nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity is enhanced by reduced CB1 receptor activity

Chihiro Nozaki, Astrid Marker, Andreas Zimmer

10th FENS Forum, Jul, 2016 Peer-reviewedLead author
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice (vol 25, pg 1388, 2015)

Chihiro Nozaki, Astrid Markert, Andreas Zimmer

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25(11) 2186-2186, Nov, 2015 Lead authorCorresponding author
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes analgesia

Raphael Weibel, Claire Gaveriaux-Ruff, Chihiro Nozaki, Xavier Nadal, Xavier C. Hever, Audrey Matifas, David Reissl, Dominique Filliol, John N. Wood, Rafael Maldonado …

PHARMACOLOGICAL REPORTS, 63(1) 243-243, Jan, 2011
Differential modulation of capsaicin-induced pain behavior by opioid receptors

Chihiro Nozaki, Claire Gaveriaux-Ruff, Brigitte Kieffer

Society for Neuroscience meeting (SfN), Oct, 2009 Lead author
Antinociceptive effect of SP1-7 on thermal hyperalgesia in diabetic mice

Chihiro Nozaki, Masahiro Ohsawa, Mathias Hallberg, Fred Nyberg, Junzo Kamei

38th International Narcotic Research Conference (INRC), Jul, 2007 Lead author
Role of cyclin-dependent kinase 5 (Cdk5) on capsaicin-induced cough reflex

Shunsuke Hayashi, Junzo Kamei, Yoshiki Takahashi, Chihiro Nozaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 260P-260P, 2007
糖尿病マウスにおけるオキシコドン髄腔内投与による鎮痛作用

野崎千尋, 斎藤顕宜, 亀井淳三

第38回日本ペインクリニック学会, Jul, 2006 Lead author
The role of ATP receptor subtypes on the painful diabetic neuropathy in mice

C Nozaki, J Kamei

JOURNAL OF PHARMACOLOGICAL SCIENCES, 100 67P-67P, Mar, 2006 Lead author

Presentations

How do sleep cycles affect Cannabidiol users? ～生活スタイルはCBDの用途や効果にどう影響するか？

野崎千尋, 潘辰語, 新田理恵, 柴田重信

春の学術セミナー2023（日本臨床カンナビノイド学会）, Apr 2, 2023
カンナビノイドCB2受容体は神経炎症を抑制するとは限らない

野崎千尋, Andreas Zimmer, 柴田重信

日本薬理学会, Dec 2, 2022
カンナビノイドの薬理：受容体が無いと我々の体はどうなってしまうのか

野崎千尋

日本臨床薬理学会, Dec 2, 2022 Invited
Cannabinoid CB2 receptors have double-side role to peripheral neuroinflammation: What makes such a difference?

Nov 5, 2022 Invited
カンナビノイド受容体が持つ二面性～抑制か？賦活か？

野崎千尋

春の学術セミナー2022（日本臨床カンナビノイド学会）, Mar 21, 2022 Invited
Endocannabinoid System in the Neuroimmunology ～大麻が我々に何をもたらすか、もしくはドイツ研究生活の実際

野崎千尋

第23回BIRD脳科学セミナー, Aug 16, 2019 Invited
Endocannabinoid System in the Neuroimmunology ～大麻が我々に何をもたらすか、もしくはドイツ研究生活の実際

野崎千尋

平成31年度採用海外特別研究員オリエンテーション及びキャリアフォーラム, Dec 7, 2018 Invited
Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain

Chihiro Nozaki, Andreas Zimmer

Aug 24, 2018 Invited
Genetic ablation of CB2 receptors enhances neuropathic pain development via boosted leptin signaling in peripheral nerves.

Chihiro Nozaki, Astrid Markert, Andreas Zimmer

The 90th Annual meeting of The Japanese Pharmacological Society, Mar 16, 2017
Contribution of endocannabinoid system on NTG-induced acute migraine-like symptoms

Chihiro Nozaki, Andreas Zimmer

18th German-Japanese Joint Symposium between the University of Bonn and Waseda University, Sep 19, 2016 Invited
Contribution of endocannabinoid system on NTG-induced acute migraine-like symptoms.

Chihiro Nozaki, Astrid Markert, Andreas Zimmer

International Narcotic Research Conference, Jul 14, 2016
Obesity and pain: Is there a link between leptin and endocannabinoid signaling?

Chihiro Nozaki, Astrid Markert, Andreas Zimmer

18th BONFOR-Symposium, Apr 29, 2015
Capsaicin-induced pain behavior is modulated in opioid receptors knockouts.

Chihiro Nozaki, Claire Gaveriaux-Ruff C, David Reiss, Audrey Matifas, Brigitte Kieffer

MOLECULAR TARGETS FOR NOVEL PAIN THERAPEUTICS: From basic research to clinical translation, Sep 23, 2010 Invited
Capsaicin-induced pain behavior is modulated by opioid receptors.

Chihiro Nozaki, Claire Gaveriaux-Ruff C, David Reiss, Audrey Matifas, Brigitte Kieffer

New Perspectives in Neuroscience: Joint Meeting of Young Italian and Japanese Neuroscientists, Sep 21, 2010 Invited
Modulation of capsaicin-induced pain behavior by opioid receptors

Chihiro Nozaki, Claire Gaveriaux-Ruff, Brigitte Kieffer

6ème Symposium du Réseau Recherche sur la Douleur, Jan 22, 2010
糖尿病性有痛性神経障害に対する各種ATP受容体の関与

野崎千尋, 亀井淳三

第79回日本薬理学会年会, Mar 9, 2006

Major Teaching Experience

Apr, 2020 - Present

Introduction to Bioscience (早稲田大学理工学術院国際理工学センター Major in Bioscience)

Professional Memberships

Research Projects

肥満が誘発する慢性炎症に関連する新たな分子・神経・免疫基盤の解明

科学研究費助成事業, 国際共同研究加速基金(帰国発展研究), 日本学術振興会, Apr, 2020 - Mar, 2023

野崎千尋
Role of endocannabinoid system on the modulation of migraine

Eigene Stelle (Temporary PI), DFG, Jan, 2016 - Dec, 2018

Chihiro Nozaki
Obesity and pain: Is there a link between leptin and endocannabinoid signaling?

Fortsetzungsantrag fur Nachwuchsgruppen, Bonfor, Jan, 2013 - Dec, 2014

Chihiro Nozaki