論文

査読有り 国際誌
2020年

The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach.

PloS one
  • Takeshi Shimamoto
  • ,
  • Nobutake Yamamichi
  • ,
  • Kenta Gondo
  • ,
  • Yu Takahashi
  • ,
  • Chihiro Takeuchi
  • ,
  • Ryoichi Wada
  • ,
  • Toru Mitsushima
  • ,
  • Kazuhiko Koike

15
6
開始ページ
e0234433
終了ページ
e0234433
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0234433
出版者・発行元
Public Library of Science (PLoS)

BACKGROUND: Several previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and the mechanism has not been elucidated. The purpose of this study is to use an epidemiological perspective to evaluate the association between H. pylori infection and the serum lipid profile. METHODS: Multivariate analysis was performed using the data of serum lipid profile, infection status of H. pylori, fitness/lifestyle habits, and various subjects' characteristics which were derived from the 15,679 generally healthy individuals in Japan. The average treatment effects (ATEs) of H. pylori infection on the serum lipid profile were estimated using augmented inverse probability weighting (AIPW). A meta-analysis was also performed using the 27 studies worldwide in which the status of H. pylori infection and at least one serum examination value (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG)) were described. RESULTS: The ATEs determined with AIPW showed that H. pylori infection has significant positive effects on LDL-C and TC (ATE (95% confidence interval [95%CI]) = 3.4 (2.36-4.49) and 1.7 (0.58-2.88), respectively) but has significant negative effects on HDL-C and TG (ATE (95%CI) = -1.2 (-1.74 to -0.72) and -3.5 (-5.92 to -1.06), respectively). The meta-analysis to estimate the association between H. pylori infection and the serum lipid profile revealed that H. pylori infection is positively associated with LDL-C, TC, and TG (standardized mean difference [SMD] (95%CI) = 0.11 (0.09-0.12), 0.09 (0.07-0.10) and 0.06 (0.05-0.08), respectively) and negatively associated with HDL-C (SMD = -0.13 (-0.14 to -0.12)). CONCLUSION: Both our multivariate analyses and meta-analysis showed that H. pylori infection significantly affects the serum lipid profile, which might lead to various dyslipidemia-induced severe diseases like coronary thrombosis or cerebral infarction.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0234433
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32511269
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279579
URL
https://dx.plos.org/10.1371/journal.pone.0234433

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