2008年6月
Parameters of optic nerve electrical stimulation affecting neuroprotection of axotomized retinal ganglion cells in adult rats
NEUROSCIENCE RESEARCH
- ,
- ,
- 巻
- 61
- 号
- 2
- 開始ページ
- 129
- 終了ページ
- 135
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.neures.2008.01.016
- 出版者・発行元
- ELSEVIER IRELAND LTD
We previously showed the enhancement of survival of retinal ganglion cells (RGCs) by electrical stimulation (ES) of the optic nerve (ON) stump in adult rats. To elucidate the mechanisms underlying the survival enhancement, we determined whether the neuroprotective effect of ES is affected by the following parameters: stimulation time, frequency of current pulses and starting of ES. ES for 10 min immediately after ON transection was not effective in increasing the number of surviving RGCs 7 days after the transection, but that for 30 min was effective. ES at 20 Hz was the most effective, when applied just after axotomy. When the starting of ES to the ON was shifted either 3 h after or 4 h before the axotomy, the neuroprotective effect of ES was not observed. These results suggest that the electrical activation of RGCs and/or the transected ON interfere with early events after axotomy that leads to RGC death. (c) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neures.2008.01.016
- ISSN : 0168-0102
- Web of Science ID : WOS:000256508000001