論文

査読有り
2014年7月

Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly

JOURNAL OF BIOCHEMISTRY
  • Gohei Nishibuchi
  • ,
  • Jun-ichi Nakayama

156
1
開始ページ
11
終了ページ
20
記述言語
英語
掲載種別
DOI
10.1093/jb/mvu032
出版者・発行元
OXFORD UNIV PRESS

Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures. HP1 has an N-terminal chromodomain and a C-terminal chromo shadow domain, linked by an unstructured hinge region. Although biochemical and structural studies have revealed each domain's properties, little is known about the mechanisms by which these domains cooperate to carry out HP1's function in forming higher-order chromatin structures. In this review, we summarize HP1's biochemical and structural properties and highlight the latest findings regarding HP1's interactions with nucleosomes.

Web of Science ® 被引用回数 : 42

リンク情報
DOI
https://doi.org/10.1093/jb/mvu032
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24825911
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000339458200002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/jb/mvu032
  • ISSN : 0021-924X
  • eISSN : 1756-2651
  • PubMed ID : 24825911
  • Web of Science ID : WOS:000339458200002

エクスポート
BibTeX RIS