2012年
Asymmetric cyanation with the Chiral Ru-Li combined catalysts
Synlett
- ,
- 巻
- 23
- 号
- 13
- 開始ページ
- 1865
- 終了ページ
- 1881
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1055/s-0032-1316545
- 出版者・発行元
- GEORG THIEME VERLAG KG
The combined systems of phenylglycinate/BINAP/Ru(II) complex and Li compounds have been found to act as highly reactive and enantioselective catalysts for cyanosilylation and hydrocyanation of aldehydes, α-keto esters, α,β-unsaturated ketones, and N-protected aldimines. In this account, we describe the concept of catalyst design, the catalytic efficiency of the novel combined systems in the asymmetric cyanation, and the proposed reaction pathway based on the spectral analysis data. 1 Introduction 2 Cyanosilylation of Aldehydes and Ketones Catalyzed by LiCl 3 Asymmetric Cyanosilylation of Aldehydes and α-Keto Esters 3.1 Design of Chiral Ru-Li Combined Catalyst Systems 3.2 Cyanosilylation of Aldehydes 3.3 Cyanosilylation of α-Keto Esters 4 Asymmetric Hydrocyanation of Aldehydes, α,β-Unsaturated Ketones, and Aldimines 4.1 Hydrocyanation of Aldehydes 4.2 Conjugate Cyanation of α,β-Unsaturated Ketones 4.3 Strecker-Type Reaction 5 Mechanistic Considerations for Cyanosilylation of Aldehydes and Ketones 5.1 Achiral Reaction Catalyzed by LiCl 5.2 Asymmetric Reaction with the Chiral Ru-Li Combined Catalyst 6 Conclusion. © Georg Thieme Verlag Stuttgart · New York.
- リンク情報
-
- DOI
- https://doi.org/10.1055/s-0032-1316545
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000307237400003&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863979873&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84863979873&origin=inward
- ID情報
-
- DOI : 10.1055/s-0032-1316545
- ISSN : 0936-5214
- eISSN : 1437-2096
- SCOPUS ID : 84863979873
- Web of Science ID : WOS:000307237400003