論文

査読有り
2005年3月

Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications

BIOMATERIALS
  • FY Cheng
  • ,
  • CH Su
  • ,
  • YS Yang
  • ,
  • CS Yeh
  • ,
  • CY Tsai
  • ,
  • CL Wu
  • ,
  • MT Wu
  • ,
  • DB Shieh

26
7
開始ページ
729
終了ページ
738
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.biomaterials.2004.03.016
出版者・発行元
ELSEVIER SCI LTD

A newly developed non-polymer coated Fe3O4 nanoparticles showing well-dispersion were synthesized using Fe(II) and Fe(III) salt chemical coprecipitation with tetramethylammonium hydroxide (N(CH3)(4)OH) in an aqueous solution. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectrometer (FT-IR), X-ray photoelectron spectrometer (XPS) and superconducting quantum interference measurement device (SQUID) measurements were employed to investigate the iron oxide properties. The resulting iron oxide particles were manipulated to be as small as 9 nm diameter in size. Based on FT-IR and X-ray photoelectron spectrometer results, it is suggested that the surfaces of the magnetite (Fe3O4) particles are covered with hydroxide (-OH) groups incorporated with (CH3)(4)N+ through electrostatic interaction. The in vitro cytotoxicity test revealed that the magnetite particles exhibited excellent biocompatibility, suggesting that they may be further explored for biomedical applications. NMR measurements revealed significantly reduced water proton relaxation times T1 and T2. The MR images of the nanoparticles in water, serum, and whole blood were investigated using a 1.5T clinical MR imager. Significant reduction of the background medium signal was achieved in the T2-weighted and the T2*-weighted sequence especially in the serum and whole blood. Combining the advantage of MRI signal contrast, the non-polymer-coated surface chemistry for distinct bioconjugation and the homogenous nanometer size for better controlled biodistribution, these preliminary experiments demonstrated the potential of the as-synthesized magnetite material in functional molecular imaging for biomedical research and clinical diagnosis. (C) 2004 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 564

リンク情報
DOI
https://doi.org/10.1016/j.biomaterials.2004.03.016
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000224319300005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.biomaterials.2004.03.016
  • ISSN : 0142-9612
  • Web of Science ID : WOS:000224319300005

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