論文

査読有り
2007年2月

Amelioration of collagen-induced arthritis in rats by nanogold

ARTHRITIS AND RHEUMATISM
  • Chiau-Yuang Tsai
  • ,
  • Ai-Li Shiau
  • ,
  • Shih-Yao Chen
  • ,
  • Yu-Hung Chen
  • ,
  • Pai-Chiao Cheng
  • ,
  • Meng-Ya Chang
  • ,
  • Dong-Hwang Chen
  • ,
  • Chen-Hsi Chou
  • ,
  • Chrong-Reen Wang
  • ,
  • Chao-Liang Wu

56
2
開始ページ
544
終了ページ
554
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/art.22401
出版者・発行元
WILEY-LISS

Objective. Angiogenesis plays a part in the pathogenesis of rheumatoid arthritis (RA), and nanogold inhibits the activity of an angiogenic factor, vascular endothelial growth factor (VEGF). We therefore investigated whether intraarticular delivery of nanogold ameliorates collagen-induced arthritis (CIA) in rats.
Methods. Binding of 13-nm nanogold to VEGF in human RA synovial fluid (SF) and its effects on RA SF-induced endothelial cell proliferation and migration were assessed. Nanogold was administered intraarticularly to rats with CIA before the onset of arthritis. Progression of CIA was monitored by measures of clinical, radiologic, and histologic changes. In addition, the microvessel density and extent of infiltrating macrophages as well as levels of tumor necrosis factor a (TNF alpha) and interleukin-1 beta (IL-1 beta) in the ankle joints were determined.
Results. Nanogold bound to VEGF in RA SF, resulting in inhibition of RA SF-induced endothelial cell proliferation and migration. Significant reductions in ankle circumference, articular index scores, and radiographic scores were observed in the nanogold-treated rats with CIA compared with their control counterparts. In addition, the histologic score (of synovial hyperplasia, cartilage erosion, and leukocyte infiltration), microvessel density, macrophage infiltration, and levels of TNF alpha and IL-1 beta were also significantly reduced in the ankle joints of nanogold-treated rats.
Conclusion. Our results are the first to demonstrate that intraarticular administration of nanogold ameliorates the clinical course of CIA in rats. Nanogold exerted antiangiogenic activities and subsequently reduced macrophage infiltration and inflammation, which resulted in attenuation of arthritis. These results demonstrate proof of principle for the use of nanogold as a novel therapeutic agent for the treatment of RA.

Web of Science ® 被引用回数 : 146

リンク情報
DOI
https://doi.org/10.1002/art.22401
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244145300018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/art.22401
  • ISSN : 0004-3591
  • Web of Science ID : WOS:000244145300018

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