論文

査読有り
2011年5月

Enhancing Transversal Relaxation for Magnetite Nanoparticles in MR Imaging Using Gd3+-Chelated Mesoporous Silica Shells

ACS NANO
  • Chih-Chia Huang
  • ,
  • Chiau-Yuang Tsai
  • ,
  • Hwo-Shuenn Sheu
  • ,
  • Kuei-Yi Chuang
  • ,
  • Chiu-Hun Su
  • ,
  • U-Ser Jeng
  • ,
  • Fong-Yu Cheng
  • ,
  • Chia-Hao Su
  • ,
  • Huan-Yao Lei
  • ,
  • Chen-Sheng Yeh

5
5
開始ページ
3905
終了ページ
3916
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/nn200306g
出版者・発行元
AMER CHEMICAL SOC

A new magnetic nanoparticle was synthesized in the form of Gd3+-chelated Fe3O4@SiO2. The Fe3O4 nanoparticle was octahedron-structured, was highly magnetic (similar to 94 emu/g), and was the core of an encapsulating mesoporous silica shell. DOTA-NHS molecules were anchored to the interior channels of the porous silica to chelate Gd3+ ions. Because there were Gd3+ ions within the silica shell, the transverse relaxivity increased 7-fold from 97 s(-1) mM(-1) of Fe3O4 to 681 s(-1) mM(-1) of Gd3+-chelated Fe3O4@SiO2 nanoparticles with r(2)/r(1) = 486. The large transversal relaxivity of the Gd3+-chelated Fe3O4@SiO2 nanoparticles had an effective magnetic resonance imaging effect and clearly imaged lymph nodes. Physiological studies of liver, spleen, kidney, and lung tissue in mice infused with these new nanoparticles showed no damage and no cytotoxicity in Kupffer cells, which indicated that Gd-3+-chelated Fe3O4@SiO2 nanoparticles are blocompatible.

Web of Science ® 被引用回数 : 61

リンク情報
DOI
https://doi.org/10.1021/nn200306g
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000290826800058&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/nn200306g
  • ISSN : 1936-0851
  • Web of Science ID : WOS:000290826800058

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