2013年5月
Epigenetic Feedback Regulation Accelerates Adaptation and Evolution
PLOS ONE
- ,
- 巻
- 8
- 号
- 5
- 開始ページ
- e61251
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pone.0061251
- 出版者・発行元
- PUBLIC LIBRARY SCIENCE
A simple cell model consisting of a gene regulatory network with epigenetic feedback regulation is studied to evaluate the effect of epigenetic dynamics on adaptation and evolution. We find that, the type of epigenetic dynamics considered enables a cell to adapt to unfamiliar environmental changes, for which no regulatory program has been prepared, through noise-driven selection of a cellular state with a high growth rate. Furthermore, we demonstrate that the inclusion of epigenetic regulation promotes evolutionary development of a regulatory network that can respond to environmental changes in a fast and precise manner. These results strongly suggest that epigenetic feedback regulation in gene expression dynamics provides a significant increase in fitness by engendering an increase in cellular plasticity during adaptation and evolution.
- リンク情報
- ID情報
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- DOI : 10.1371/journal.pone.0061251
- ISSN : 1932-6203
- PubMed ID : 23667436
- Web of Science ID : WOS:000319055600010