論文

査読有り
2015年

Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder

MAGNETIC RESONANCE IN MEDICAL SCIENCES
  • Tomoko Kobayashi
  • ,
  • Yoshiyuki Hirano
  • ,
  • Kiyotaka Nemoto
  • ,
  • Chihiro Sutoh
  • ,
  • Kazuhiro Ishikawa
  • ,
  • Haruko Miyata
  • ,
  • Junko Matsumoto
  • ,
  • Koji Matsumoto
  • ,
  • Yoshitada Masuda
  • ,
  • Michiko Nakazato
  • ,
  • Eiji Shimizu
  • ,
  • Akiko Nakagawa

14
4
開始ページ
329
終了ページ
335
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2463/mrms.2014-0146
出版者・発行元
JPN SOC MAGNETIC RESONANCE IN MEDICINE

Objectives: Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric disorders, with some speculating that a reason for difficulty in its treatment might be its coexistence with autism spectrum. We investigated the tendency for autistic spectrum disorders (ASD) in patients with OCD from a neuroimaging point of view using voxel-based morphometry.
Methods: We acquired T-1-weighted images from 20 patients with OCD and 30 healthy controls and investigated the difference in regional volume between the groups as well as the correlation between Autism-Spectrum Quotient (AQ) scores and regional cerebral volumes of patients with OCD.
Results: Volumes in the bilateral middle frontal gyri were significantly decreased in patients with OCD compared to controls. Correlational analysis showed significant positive correlations between AQ scores and regional gray matter (GM) volumes in the left dorsolateral prefrontal cortex (DLPFC) and left amygdala. Furthermore, GM volumes of these regions were positively correlated with each other.
Conclusions: The positive correlation of ASD traits in patients with OCD with regional GM volumes in the left DLPFC and amygdala could reflect the heterogeneity of patient symptoms. Our results suggest that differences in GM volume might allow classification of patients with OCD for appropriate therapy based on their particular traits.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.2463/mrms.2014-0146
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26104070
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000364260200010&DestApp=WOS_CPL
ID情報
  • DOI : 10.2463/mrms.2014-0146
  • ISSN : 1347-3182
  • eISSN : 1880-2206
  • PubMed ID : 26104070
  • Web of Science ID : WOS:000364260200010

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