論文

査読有り
2015年9月

Sex differences in fear extinction and involvements of extracellular signal-regulated kinase (ERK)

NEUROBIOLOGY OF LEARNING AND MEMORY
  • Shingo Matsuda
  • ,
  • Daisuke Matsuzawa
  • ,
  • Daisuke Ishii
  • ,
  • Haruna Tomizawa
  • ,
  • Chihiro Sutoh
  • ,
  • Eiji Shimizu

123
開始ページ
117
終了ページ
124
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.nlm.2015.05.009
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Stress-related disorders, such as post-traumatic stress disorder (PTSD) and panic disorders, are disproportionately prevalent in females. However, the biological mechanism underlying these sex differences in the prevalence rate remains unclear. In the present study, we examined sex differences in fear memory, fear extinction, and spontaneous recovery of fear. We investigated the presence of sex differences in recent and remote fear memory in mice using contextual fear conditioning, as well as sex differences in spontaneous recovery of fear memory using a consecutive fear extinction paradigm. We examined the number of fear extinction days required to prevent spontaneous recovery of fear in either sex. We investigated whether ovariectomy affected fear extinction and spontaneous recovery. We also measured the activation of extracellular signal-regulated kinase (ERK) 1 and 2 in the dorsal hippocampus and the medial prefrontal cortex following fear extinction sessions. In our results, we found no sex difference in recent or remote fear memory. However, females required more fear extinction sessions compared to males to prevent spontaneous recovery. Within-extinction freezing also differed between males and females. Moreover, females required more extinction sessions than males to increase ERK2 phosphorylation in the dorsal hippocampus. Our data suggest that contextual fear extinction was unstable in females compared to males and that such sex differences may be related to the ERK2 phosphorylation in the hippocampus. (C) 2015 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 27

リンク情報
DOI
https://doi.org/10.1016/j.nlm.2015.05.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26079214
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000359510900015&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.nlm.2015.05.009
  • ISSN : 1074-7427
  • eISSN : 1095-9564
  • PubMed ID : 26079214
  • Web of Science ID : WOS:000359510900015

エクスポート
BibTeX RIS