論文

査読有り
2015年7月

An isolated retrieval trial before extinction session does not prevent the return of fear

BEHAVIOURAL BRAIN RESEARCH
  • Daisuke Ishii
  • ,
  • Daisuke Matsuzawa
  • ,
  • Shingo Matsuda
  • ,
  • Haruna Tomizawa
  • ,
  • Chihiro Sutoh
  • ,
  • Eiji Shimizu

287
開始ページ
139
終了ページ
145
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbr.2015.03.052
出版者・発行元
ELSEVIER SCIENCE BV

Several studies have shown that an isolated retrieval trial before the extinction session (retrieval-extinction) prevents the return of fear memory by inhibition of reconsolidation. Other studies have reported that retrieval-extinction did not prevent the return of the fear. To date, it is still unclear whether retrieval-extinction prevents the return of the original fear memory. A previous study revealed that reconsolidation of conditioned fear memory was not induced by the brevity of the retrieval session. Thus, we examined whether the number of retrievals in the retrieval-extinction paradigm was involved in the prevention of return of fear (Experiment 1). Furthermore, studies with different-age experimental subjects have shown conflicting results. We investigated the potential impact of age on the inhibitory effect of retrieval-extinction on the return of fear (Experiment 2). Our major findings were as follows: (1) Retrieval-extinction procedure did not prevent the return of fear, regardless of the intensity (number of presentations) of the stimulus inducing retrieval of fear memory. (2) The mice in both juvenile and adult age groups (4 and 8 weeks old) retrieved fear memory after retrieval-extinction. These results suggest the possibility that extinction after retrieval does not inhibit reconsolidation of previously consolidated fear memory. (C) 2015 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1016/j.bbr.2015.03.052
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25827926
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000355037700018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.bbr.2015.03.052
  • ISSN : 0166-4328
  • eISSN : 1872-7549
  • PubMed ID : 25827926
  • Web of Science ID : WOS:000355037700018

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