論文

査読有り
2017年10月

Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder

BRAIN IMAGING AND BEHAVIOR
  • Motohisa Hirose
  • ,
  • Yoshiyuki Hirano
  • ,
  • Kiyotaka Nemoto
  • ,
  • Chihiro Sutoh
  • ,
  • Kenichi Asano
  • ,
  • Haruko Miyata
  • ,
  • Junko Matsumoto
  • ,
  • Michiko Nakazato
  • ,
  • Koji Matsumoto
  • ,
  • Yoshitada Masuda
  • ,
  • Masaomi Iyo
  • ,
  • Eiji Shimizu
  • ,
  • Akiko Nakagawa

11
5
開始ページ
1326
終了ページ
1333
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s11682-016-9611-9
出版者・発行元
SPRINGER

Obsessive-compulsive disorder (OCD) is known as a clinically heterogeneous disorder characterized by symptom dimensions. Although substantial numbers of neuroimaging studies have demonstrated the presence of brain abnormalities in OCD, their results are controversial. The clinical heterogeneity of OCD could be one of the reasons for this. It has been hypothesized that certain brain regions contributed to the respective obsessive-compulsive dimensions. In this study, we investigated the relationship between symptom dimensions of OCD and brain morphology using voxel-based morphometry to discover the specific regions showing alterations in the respective dimensions of obsessive-compulsive symptoms. The severities of symptom dimensions in thirty-three patients with OCD were assessed using Obsessive-Compulsive Inventory-Revised (OCI-R). Along with numerous MRI studies pointing out brain abnormalities in autistic spectrum disorder (ASD) patients, a previous study reported a positive correlation between ASD traits and regional gray matter volume in the left dorsolateral prefrontal cortex and amygdala in OCD patients. We investigated the correlation between gray and white matter volumes at the whole brain level and each symptom dimension score, treating all remaining dimension scores, age, gender, and ASD traits as confounding covariates. Our results revealed a significant negative correlation between washing symptom dimension score and gray matter volume in the right thalamus and a significant negative correlation between hoarding symptom dimension score and white matter volume in the left angular gyrus. Although our result was preliminary, our findings indicated that there were specific brain regions in gray and white matter that contributed to symptom dimensions in OCD patients.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1007/s11682-016-9611-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27730476
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000413604900008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s11682-016-9611-9
  • ISSN : 1931-7557
  • eISSN : 1931-7565
  • PubMed ID : 27730476
  • Web of Science ID : WOS:000413604900008

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