論文

査読有り
2017年6月1日

Relationship between symptom dimensions and white matter alterations in obsessive-compulsive disorder

Acta Neuropsychiatrica
  • Michiyo Yagi
  • ,
  • Yoshiyuki Hirano
  • ,
  • Michiko Nakazato
  • ,
  • Kiyotaka Nemoto
  • ,
  • Kazuhiro Ishikawa
  • ,
  • Chihiro Sutoh
  • ,
  • Haruko Miyata
  • ,
  • Junko Matsumoto
  • ,
  • Koji Matsumoto
  • ,
  • Yoshitada Masuda
  • ,
  • Takayuki Obata
  • ,
  • Masaomi Iyo
  • ,
  • Eiji Shimizu
  • ,
  • Akiko Nakagawa

29
3
開始ページ
153
終了ページ
163
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1017/neu.2016.45

© Scandinavian College of Neuropsychopharmacology 2016. Objective: To investigate the relationship between the severities of symptom dimensions in obsessive-compulsive disorder (OCD) and white matter alterations. Methods: We applied tract-based spatial statistics for diffusion tensor imaging (DTI) acquired by 3T magnetic resonance imaging. First, we compared fractional anisotropy (FA) between 20 OCD patients and 30 healthy controls (HC). Then, applying whole brain analysis, we searched the brain regions showing correlations between the severities of symptom dimensions assessed by Obsessive-Compulsive Inventory-Revised and FA in all participants. Finally, we calculated the correlations between the six symptom dimensions and multiple DTI measures [FA, axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD)] in a region-of-interest (ROI) analysis and explored the differences between OCD patients and HC. Results: There were no between-group differences in FA or brain region correlations between the severities of symptom dimensions and FA in any of the participants. ROI analysis revealed negative correlations between checking severity and left inferior frontal gyrus white matter and left middle temporal gyrus white matter and a positive correlation between ordering severity and right precuneus in FA in OCD compared with HC. We also found negative correlations between ordering severity and right precuneus in RD, between obsessing severities and right supramarginal gyrus in AD and MD, and between hoarding severity and right insular gyrus in AD. Conclusion: Our study supported the hypothesis that the severities of respective symptom dimensions are associated with different patterns of white matter alterations.

リンク情報
DOI
https://doi.org/10.1017/neu.2016.45
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27620171
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84987600871&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84987600871&origin=inward
ID情報
  • DOI : 10.1017/neu.2016.45
  • ISSN : 0924-2708
  • eISSN : 1601-5215
  • PubMed ID : 27620171
  • SCOPUS ID : 84987600871

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