論文

査読有り 国際誌
2020年6月2日

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms.

Nature communications
  • Amit K Subudhi
  • ,
  • Aidan J O'Donnell
  • ,
  • Abhinay Ramaprasad
  • ,
  • Hussein M Abkallo
  • ,
  • Abhinav Kaushik
  • ,
  • Hifzur R Ansari
  • ,
  • Alyaa M Abdel-Haleem
  • ,
  • Fathia Ben Rached
  • ,
  • Osamu Kaneko
  • ,
  • Richard Culleton
  • ,
  • Sarah E Reece
  • ,
  • Arnab Pain

担当区分
責任著者
11
1
開始ページ
2763
終了ページ
2763
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-020-16593-y
出版者・発行元
Springer Science and Business Media {LLC}

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium falciparum genes show 24 h rhythms in expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a 24 h transcriptional rhythm and disrupting it in rodent malaria parasites shortens the IDC by 2-3 h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10. Our results reveal malaria parasites are at least partly responsible for scheduling the IDC and coordinating their development with host daily rhythms.

リンク情報
DOI
https://doi.org/10.1038/s41467-020-16593-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32488076
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265539
URL
http://www.nature.com/articles/s41467-020-16593-y.pdf
URL
http://www.nature.com/articles/s41467-020-16593-y

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