2007年10月31日
真核生物の複製制御因子GINS複合体の構造解析
日本結晶学会誌
- 巻
- 49
- 号
- 5
- 開始ページ
- 286
- 終了ページ
- 291
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.5940/jcrsj.49.286
- 出版者・発行元
- 日本結晶学会
The eukaryotic GINS complex is essential for the establishment of DNA replication forks and replisome progression. We report the crystal structure of the human GINS complex. The heterotetrameric complex adopts a pseudo symmetrical layered structure comprising two heterodimers, creating four subunit-subunit interfaces. The structural and biochemical data suggest that the tetrameric complex ensures a stable platform for the C-terminal domain of Psfl to act as a key interaction interface for other proteins in the replication-initiation process.
- リンク情報
-
- DOI
- https://doi.org/10.5940/jcrsj.49.286
- CiNii Articles
- http://ci.nii.ac.jp/naid/10019794361
- CiNii Books
- http://ci.nii.ac.jp/ncid/AN00188364
- ID情報
-
- DOI : 10.5940/jcrsj.49.286
- ISSN : 0369-4585
- CiNii Articles ID : 10019794361
- CiNii Books ID : AN00188364
- identifiers.cinii_nr_id : 9000002003369