Daisuke Yabe

J-GLOBAL         Last updated: Jul 2, 2019 at 02:42
 
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Name
Daisuke Yabe
Alternative names
Dai Yabe
E-mail
ydaisuke-kyotoumin.ac.jp
Affiliation
Gifu University
Section
Graduate School of Medicine
Job title
Professor and Chairman
Degree
MD(Kyoto University), PhD(University of Texas Southwestern Medical Center at Dallas)
Other affiliation
Division of Molecular and Metabolic Medicine, Kobe University Graduate School of MedicineKansai Electric Power Medical Research InstituteDepartment of Diabetes, Endocrinology and Nutrition
Research funding number
60378643
ORCID ID
0000-0002-5334-7687

Profile

Dr. Daisuke Yabe has been investigating pathophysiology of type 2 diabetes in Asian population. His clinical research interests include secretion and action of incretins GLP-1 and GIP, as well as clinical safety and efficacy of incretin-based therapies in management of type 2 diabetes. He also studies molecular basis underlying aging of pancreatic beta cells; and beta cell heterogeneity. Dr. Yabe obtained MD degree from Kyoto University Faculty of Medicine (Japan), and PhD degree from the University of Texas Southwestern Graduate School of Biomedical Sciences (USA). Dr. Yabe serves as Professor and Chairman for Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine (Japan), Deputy Director General for Kansai Electric Power Medical Research Institute (Japan), Visiting Associate Professor for Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine (Japan), and Visiting Scholar for Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine (Japan). While Dr. Yabe is actively involved in clinical and basic research related to diabetes, he is also dedicated for diabetes care and education as a diabetes specialist. He has served as a member of the IDF Science Taskforce, and he is an active member of the International Affairs Committee, the Science Committee and the Diabetes Education Committee, The Japan Association for Diabetes Education and Care; and the International Affairs Committee and the Public Relations Committee, The Japan Diabetes Society.

Research Areas

 

Academic & Professional Experience

 
Apr 2019
 - 
Today
Visiting Professor, Kobe University Graduate School of Medicine
 
Apr 2019
 - 
Today
Adjunct Lecturer, Kyoto University Faculty of Medicine
 
Dec 2018
 - 
Mar 2019
Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine
 
Dec 2018
 - 
Today
Professor and Chairman, Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine
 
Apr 2016
 - 
Nov 2018
Program-Specific Associate Professor, Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine
 
Jul 2015
 - 
Today
Director, Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute
 
Jul 2015
 - 
Today
Deputy Director General, Kansai Electric Power Medical Research Institute
 
Apr 2011
 - 
Mar 2019
Visiting Associate Professor, Kobe University Graduate School of Medicine
 
Jan 2013
 - 
Mar 2016
Chief Director, Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital
 
Jan 2013
 - 
Mar 2016
Director, Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital
 

Awards & Honors

 
Sep 2017
Outstanding Research Award, The Japan Society of Constitutional Medicine
 
May 2017
The Masato Kasuga Award for Outstanding Scientific Achivement, Asian Association for the Study of Diabetes
 
Jan 2016
Albireo Award, Japan Society of Metabolism and Clinical Nutrition
 
Jul 2013
William Cullen Award, Japan Association for Diabetes Education and Care
 
Jun 2013
Yutaka Seino Award 2012 for Diabetes Research and Medical Cooperation, Study Group for Medical Cooperation
 

Published Papers

 
A rare case of autoimmune polyglandular syndrome with Sjögren’s syndrome and primary hypoparathyroidism.
Iizuka K, Mizuno M, Nonomura K; Yabe D
BMJ Case Reports   12(5) e228634   May 2019   [Refereed]
Bullous Pemphigoid with Dipeptidyl Peptidase-4 Inhibitors: Clinical Features and Pathophysiology
Murakami T, Yabe D, Inagaki N
Journal of Diabetes Investigation   in press    Apr 2019   [Refereed][Invited]
Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion
Liu Y, Harashima S-I, Wang Y, Suzuki K, Tokumoto S, Usui R, Tatsuoka H, Tanaka D, Yabe D, Harada N, Hayashi Y, Inagaki N.
The FASEB Journal   in press    Jan 2019   [Refereed]
Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity
Usui R, Yabe D, Seino Y
Journal of Diabetes Investigation   in press    Jan 2019   [Refereed][Invited]
Case 23-2018: A Man with Episodes of Confusion and Hypoglycemia
Murakami T, Yabe D, Inagaki N
New England Journal of Medicine   379 1881-182   Nov 2018   [Refereed]
Safety and tolerability of empagliflozin in East Asian patients type 2 diabetes: pooled analysis of Phase I–III clinical trials.
Yabe D, Yasui A, Ji L, Lee MK, Ma RCW, Chang TJ, Okamura T, Zeller C, Kaspers S, Lee J, Kohler S, Seino Y.
Journal of Diabetes Investigation   in press    Aug 2018   [Refereed]
Hypoglycemia Unawareness in Insulinoma revealed with Flash Glucose Monitoring
Sugawa T, Murakami T, Yabe D, Kashima R, Tatsumi M, Ooshima S, Joo E, Wada K, Yoshizawa A, Masui T, Nakamoto Y, Yamauchi Y, Kodama Y, Iemura Y, Ogura M, Yasoda A, Inagaki N
Internal Medicine   in press    May 2018   [Refereed]
Reply to the comment of Wilbrink et al on “Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β-cell function and the achievement of the HbA1c target one year after in
Usui R, Sakuramachi Y, Seino Yus, Murotani K, Kuwata H, Tatsuoka H, Hamamoto Y, Kurose T, Seino Yut, Yabe D.
J Diabetes Investig   9(3) 981-983   Jul 2018   [Refereed]
Japanese Clinical Practice Guideline for Diabetes 2016
Masakazu Haneda, Mitsuhiko Noda, Hideki Origasa, Hiroshi Noto, Daisuke Yabe, Yukihiro Fujita, Atsushi Goto, Tatsuya Kondo, Eiichi Araki
Journal of Diabetes Investigation   9(3) 657-697   May 2018   [Refereed][Invited]
Mental distress and health-related quality of life among type 1 and type 2 diabetes patients using self-monitoring of blood glucose: A cross-sectional questionnaire study in Japan
Tanaka N, Yabe D, Murotani K, Ueno S, Kuwata H, Hamamoto Y, Kurose T, Takahashi N, Akashi T, Matsuoka T, Osonoi T, Minami M, Shimono D, Seino Y, The Positive SMBG Study Group Investigators
J Diabetes Investig   9(5) 1203-1211   Sep 2018   [Refereed]
Etoh H, Takasaki M, Sato H, Teramura S, Shimizu S, Yabe D, Fujimoto Y, Seino Y
Neurosonology   31(1) 1-6   Jan 2018   [Refereed]
Relationship between deterioration of HbA1c-lowering effects in DPP-4 inhibitor monotherapy and dietary habits: Retrospective analysis of Japanese individuals with type 2 diabetes
Kuwata H, Okamoto S, Seino Yus, Murotani K, Tatsuoka H, Usui R, Hamamoto Y, Kurose T, Seino Yut, Yabe D
J Diabetes Investig   9(5) 1153-1158   Sep 2018   [Refereed]
Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β-cell function and the achievement of the HbA1c target one year after initiation.
Usui R, Sakuramachi Y, Seino Yus, Murotani K, Kuwata H, Tatsuoka H, Hamamoto Y, Kurose T, Seino Yut, Yabe D
J Diabetes Investig   9(4) 822-830   Jul 2018   [Refereed]
Beta cell replacement strategies for diabetes.
Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N.
J Diabetes Investig   9(3) 457-463   Oct 2017   [Refereed][Invited]
Seino Y, Terauchi Y, Osonoi T, Yabe D, Abe N, Nishida T, Zacho J, Kaneko S
Diabetes, Obesity and Metabolism   20(2) 378-388   Feb 2018   [Refereed]
Yabe D, Seino Yus, Seino Yut
Journal of Diabetes Investigation   9(1) 21-24   Jan 2018   [Refereed][Invited]
Sodium glucose co-transporter 2 inhibitor luseogliflozin in the management of type 2 diabetes: a drug safety evaluation
Yabe D, Hamamotoa Y, Seino Yus,Kuwata H, Kurose T, Seino Yut
Expert Opinion in Drug Safety   16(10) 1211-1218   Oct 2017   [Refereed][Invited]
Yoshiji S, Murakami T, Harashima SI, Ko R, Kashima R, Yabe D, Ogura M, Doi K, Inagaki N
J Diabetes Investigation   9(2) 445-447   Mar 2018   [Refereed]
Murakami T, Yamashita T, Yabe D, Masui T, Teramoto Y, Minamiguchi S, Hirota K, Ogura M, Nagashima K, Inagaki N
Internal Medicine   56(23) 3199-3204   Dec 2017   [Refereed]
Terauchi Y, Yamada Y, Ishida H, Ohsugi M, Kitaoka M, Satoh J, Yabe D, Shihara N, Seino Y.
Diabetes Obesity and Metabolism   19(8) 1188-1192   Aug 2017   [Refereed]
Yabe D, Eto T, Shiramoto M, Irie S, Murotani K, Seino Yus, Kuwata H, Kurose T, Seino S, Ahren B, Seino Y.
Diabetes, Obesity and Metabolism   19(3) 442-447   Mar 2017   [Refereed]
Yabe D, Iwasaki M, Kuwata H, Haraguchi T, Hamamoto Y, Kurose T, Sumita K, Yamazato H, Kanada S, Seino Y
Diabetes, Obesity and Metabolism   19(5) 739-743   May 2017   [Refereed]
Daisuke Yabe and Yutaka Seino
Journal of Diabetes Investigation   8(3) 272-276   May 2017   [Refereed][Invited]
Yabe D, Ambos A, Cariou B, Duvnjak L, Evans M, González-Gálvez G, Lin J, Nikonova EV, de Pablos-Velasco P, Yale JF, Ahrén B
Journal of Diabetes and its Complications   30(7) 1385-1392   May 2016   [Refereed]
Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y.
Diabetologia   59(7) 1533-1541   Apr 2016   [Refereed]
Kuwata H, Iwasaki M, Shimizu S, Minami K, Maeda H, Seino S, Nakada K, Nosaka C, Murotani K, Kurose T, Seino Y, Yabe D
Diabetologia   59(3) 453-461   Mar 2016   [Refereed]
Sasabe S.A., Fukushima, M, Xin X, Taniguchi A, Nakai Y, Mitsui R, Takahashi Y, Tsuji H, Yabe D, Yasuda K, Kurose, T, Inagaki N, Seino Y.
Journal of Diabetes Research   2016 1298601   Feb 2016   [Refereed]
Yabe D, Seino Y
Expert Opinion On Drug Safety   15(2) 249-264   Feb 2016   [Refereed][Invited]
Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y
J Diabetes Complications   29 413-421   Dec 2015   [Refereed]
Why are incretin-based therapies more efficient in East Asians? Perspectives from the pathophysiology of type 2 diabetes and East Asian dietary habits
Yabe D, Kuwata H, Iwasaki M, Seino Y
European Medical Journal   3(1) 57-65   Nov 2015   [Refereed][Invited]
Yabe D, Seino Y
Lancet Diabetes Endocrinol   4(1) 2-3   Nov 2015   [Refereed][Invited]
Rokutan M, Yabe D, Komoto I, Kurose T, Kawai J,TNakamura T, Imamura M, Seino Y
Endocrine Journal   62(11) 1025-1030   Jul 2015   [Refereed]
Tajima N, Noda M, Origasa H, Noto H, Yabe D, Fujita Y, Goto A, Fujimoto K, Sakamoto M, Haneda M.
Diabetology International   in press    Jul 2015   [Refereed]
Seino Y, Yabe D, Takami A, Niemoeller E, Takagi H.
J Diabetes Complications   29(8) 1203-1210   Jul 2015   [Refereed]
Yabe D, Seino Y, Fukushima M, Seino S
Current Diabetes Reports,   15(6) 602-602   Jun 2015   [Refereed][Invited]
Onishi Y, Niemoeller E, Ikeda, Y, Takagi H, Yabe D, Seino Y
Journal of Diabetes Investigation   6(2) 201-206   Apr 2015   [Refereed]
Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, Murorani K, Kurose T, Seino Y.
Diabetes, Obesity and Metabolism   17(4) 430-437   Apr 2015   [Refereed]
Kuramoto N, Yabe D, Kurose T, Seino Y
Diabetes Research and Clinical Practice   108(1) e8-e10   Apr 2015   [Refereed]
Seino Y, Ikeda Y, Niemoeller E, Watanabe D, Takagi H, Yabe D, Inagaki N
Hormone and Metabolic Research   47(12) 895-900   Apr 2015   [Refereed]
Yabe D, Kuwata H, Usui R, Kurose T, Seino Y
Current Medical Research & Opinion   31(7) 1267-1270   Apr 2015   [Refereed][Invited]
Yabe D, Nishikino R, Kaneko M, Iwasaki M, Seino Y
Expert Opinion on Drug Safety   in press    Mar 2015   [Refereed]
Sasabe S.A., Xin X, Taniguchi A, Nakai Y, Mitsui R, Tsuji H, Yabe D, Yasuda K, Kurose, T, Inagaki N, Seino Y, Fukushima, M.
Journal of Diabetes Investigation   5(6) 663-670   Nov 2014   [Refereed]
Yabe D, Seino Y
Journal of Diabetes Investigation   5(5) 475-477   Sep 2014   [Refereed][Invited]
Yabe D, Seino Y
Expert Review of Endocrinology and Metabolism   9(6) 547-559   Sep 2014   [Refereed][Invited]
Kubota A, Yabe D, Kanamori A, Kuroe A, Takahashi N, Saito T, Matsuba I, Nabe K, Kurose T, Seino Y
Journal of Diabetes Investigation   5(4) 445-448   Aug 2014   [Refereed]
The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes
Kurose T, Hyo T, Yabe D, Seino Y
ChronoPhysiology and Therapy   4 41-49   Jul 2014   [Refereed][Invited]
Yabe D, Seino Y
Expert Review of Endocrinology and Metabolism   9(6) 659-670   Jul 2014   [Refereed][Invited]
Seino Y, Yabe D
Expert Opinion On Pharmacotherapy   15(6) 851-863   Jun 2014   [Refereed][Invited]
Kurashina T, Nagasaka S, Watanabe N, Yabe D, Sugi N, Nin K, Hosokawa M, Nomura Y, Fukushima M, Nakai Y, Nishimura F, Taniguchi A.
J Atheroscler Thromb   21(7) 730-738   Apr 2014   [Refereed]
Strain WD, Cos X, Hirst M, Venciod S, Mohan V, Vokó Z, Yabe D, Blüher M, Paldánius PM.
Diabetes Research and Clinical Practice   105(3) 302-312   Apr 2014   [Refereed]
Yabe D, Seino Y
Current Opinion in Pharmacology   13(6) 946-953   Dec 2013   [Refereed][Invited]
Yabe D, Rokutan M, Komoto I, Usui R, Kuwata H, Watanabe K, Hyo T, Kurose T, Nagamatsu T, Shimizu S, Kawai J, Imamura M, Seino Y.
Diabetes Research and Clinical Practice   102(1) e1-e4   Oct 2013   [Refereed]
Kobayakawa A, Suzuki T, Ikami T, Saito M, Yabe D, Seino Y.
J Diet Suppl.   10(2) 129-141   Jun 2013   [Refereed]
Seino Y, Yabe D
Journal of Diabetes Investigation   4(2) 108-130   Mar 2013   [Refereed][Invited]
Izumi Y, Yabe D, Taniguchi A, Fukushima M, Nakai Y, Hosokawa M, Okumura T, Nin K, Matsumoto K, Nishimura F, Nagasaka S, Seino Y
Diabetes Research and Clinical Practice   99(2) 145-150   Feb 2013   [Refereed]
Usui R, Yabe D, Kuwata H, Fujiwara S, Watanabe K, Hyo T, Yasuhara A, Iwasaki M, Kitatani N, Kuwabara K, Yokota K, Kurose T, SeinoY
Journal of Diabetes Investigation      2013   [Refereed]
T Senmaru, M Fukui, K Kobayashi, H Iwase, S Inada, H Okada, M Asano, M Yamazaki, G Hasegawa, N Nakamura, M Iwasaki, Yabe D., T Kurose, Y Seino.
Journal of Diabetes Investigation   3(6) 498-502   Dec 2012   [Refereed]
M Iwasaki, F Hoshian, T Tsuji, N Hirose, T Matsumoto, N Kitatani, K Sugawara, R Usui, H Kuwata, K Sugizaki, Y Kitamoto, S Fujiwara, K Watanabe, T Hyo, T Kurose, Y Seino, D Yabe
Journal of Diabetes Investigation   3(5) 464-467   Oct 2012   [Refereed]
Drug-induced generalized itching erythema in diabetes mellitus receiving dipeptidyl peptidase-IV inhibitors plus metformin
Nakatani K, Kurose T, Watanabe K, Matsumoto M, Fujiwara S, Usui R, Kuwata H, Hyo T, Yabe D, Seino Y
Diabetes Therapy   3(1) 14   Oct 2012   [Refereed]
Sakurai K, Lee EY, Morita A, Kimura S, Kawamura H, Kasamatsu A, Shiiba M, Yabe D,Yokote K, Miki T.
Journal of Diabetes Investigation   3(2) 156-163   Aug 2012   [Refereed]
Mitsui, R, Fukushima M, Taniguchi A, Nakai Y, Aoyama S, Takahashi Y, Tsuji H, Yabe D, Yasuda K, Kurose T, Kawakita T, Seino Y, Inagaki N.
Journal of Diabetes Investigation   3(4) 377-383   Aug 2012   [Refereed]
Yabe D and Seino Y
Journal of Diabetes Investigation   3(4) 347-348   Aug 2012   [Refereed][Invited]
Nagayasu S, Suzuki S, Yamashita A, Taniguchi A, Fukushima M, Nakai Y, Watanabe N, Nagasaka S, Yabe D, Nishimura F, Nin K.
Tobacco Induced Diseases   10(1) 3   Mar 2012   [Refereed]
Yabe D, Watanabe K, Sugawara K, Kuwata H, Kitamoto Y, Sugizaki K, Fujiwara S, Hishizawa M, Hyo T, Kuwabara K, Yokota K, Iwasaki M, Kitatani N, Kurose T, Inagaki N, Seino Y.
Journal of Diabetes Investigation   3(1) 70-79   Feb 2012   [Refereed]
Watanabe N, Fukushima M, Taniguchi A, Okumura T, Nomura Y, Nishimura F, Aoyama S, Yabe D, Izumi Y, Otsubo R, Nakai Y, Nagasaka S.
Tobacco Induced Disease   9(1) 12   Nov 2011   [Refereed]
Yabe D, Seino Y
Clinical Medicine Insights: Endocrinology and Diabetes   4 47-62   Sep 2011   [Refereed][Invited]
Yabe D, Seino Y
Progress in biophysics and molecular biology   128(2) 125-134   Jun 2011   [Refereed][Invited]
Circadian rhythms and diabetes
Kurose T, Yabe D, Inagaki N.
Journal of Diabetes Investigation   2(3) 176-177   2011   [Refereed]
Yabe D, Kuroe A, Lee S, Watanabe K, Hyo T, Hishizawa M, Kurose T, Deacon CF, Holst JJ, Hirano T, Inagaki N, Seino Y.
Journal of Diabetes Investigation   1(1/2) 56-59   May 2010   [Refereed]
Seino Y, Fukushima M, Yabe D.
Journal of Diabetes Investigation   1(1/2) 8-23   May 2010   [Refereed][Invited]
Watanabe K, Kurose T, Kitatani N, Yabe D, Hishizawa M, Hyo T, Seino Y
Internal medicine (Tokyo, Japan)   49(11) 983-989   2010   [Refereed]
Lee S, Yabe D, Nohtomi K, Takada M, Morita R, Seino Y, Hirano T
Endocrine journal   57(2) 119-126   2010   [Refereed]
Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, Kimura T, Nakamura T
Proceedings of the National Academy of Sciences of the United States of America   106(45) 19029-19034   Nov 2009   [Refereed]
Yabe D, Kuroe A, Ohya M, Watanabe K, Kitatani N, Oku M, Kurose T, Seino Y
Diabetes research and clinical practice   82 e1-4   Nov 2008   [Refereed]
Fujikura J, Hosoda K, Kawaguchi Y, Noguchi M, Iwakura H, Odori S, Mori E, Tomita T, Hirata M, Ebihara K, Masuzaki H, Fukuda A, Furuyama K, Tanigaki K, Yabe D, Nakao K
Developmental dynamics : an official publication of the American Association of Anatomists   236 2779-2791   Oct 2007   [Refereed]
Takebayashi S, Yamamoto N, Yabe D, Fukuda H, Kojima K, Ito J, Honjo T
Developmental biology   307(1) 165-178   Jul 2007   [Refereed]
Yabe D, Fukuda H, Aoki M, Yamada S, Takebayashi S, Shinkura R, Yamamoto N, Honjo T
Genesis (New York, N.Y. : 2000)   45 300-306   May 2007   [Refereed]
Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K, Nagaoka H, Yabe D, Honjo T
Proceedings of the National Academy of Sciences of the United States of America   104(5) 1616-1620   Jan 2007   [Refereed]
Tsuji M, Shinkura R, Kuroda K, Yabe D, Honjo T
Proceedings of the National Academy of Sciences of the United States of America   104(5) 1610-1615   Jan 2007   [Refereed]
Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K
Cell metabolism   3 59-65   Jan 2006   [Refereed]
Yamamoto N, Tanigaki K, Tsuji M, Yabe D, Ito J, Honjo T
Journal of molecular medicine (Berlin, Germany)   84 37-45   Jan 2006   [Refereed]
Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA
The Journal of biological chemistry   278(52) 52479-52490   Dec 2003   [Refereed]
Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS
Proceedings of the National Academy of Sciences of the United States of America   100(6) 3155-3160   Mar 2003   [Refereed]
Yabe D, Xia ZP, Adams CM, Rawson RB
Proceedings of the National Academy of Sciences of the United States of America   99(26) 16672-16677   Dec 2002   [Refereed]
Yabe D, Brown MS, Goldstein JL
Proceedings of the National Academy of Sciences of the United States of America   99(20) 12753-12758   Oct 2002   [Refereed]
Espenshade PJ, Li WP, Yabe D
Proceedings of the National Academy of Sciences of the United States of America   99(18) 11694-11699   Sep 2002   [Refereed]
Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS
Cell   110 489-500   Aug 2002   [Refereed]
Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ
Cell   102(3) 315-323   Aug 2000   [Refereed]
Nakamura T, Ruiz-Lozano P, Lindner V, Yabe D, Taniwaki M, Furukawa Y, Kobuke K, Tashiro K, Lu Z, Andon NL, Schaub R, Matsumori A, Sasayama S, Chien KR, Honjo T
The Journal of biological chemistry   274(32) 22476-22483   Aug 1999   [Refereed]
Nakamura T, Yabe D, Kanazawa N, Tashiro K, Sasayama S, Honjo T
Genomics   54(1) 89-98   Nov 1998   [Refereed]
Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T
Genomics   49(2) 331-333   Apr 1998   [Refereed]
Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC)
Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, O'Brien SJ
Science (New York, N.Y.)   279 389-393   Jan 1998   [Refereed]
Yabe D, Nakamura T, Kanazawa N, Tashiro K, Honjo T
The Journal of biological chemistry   272(29) 18232-18239   Jul 1997   [Refereed]

Conference Activities & Talks

 
Education and care, that is the issue to better manage diabetes [Invited]
Daisuke Yabe
Central Asian Diabetology Forum 2019   29 May 2019   
Encouraging your submissions to international journals [Invited]
Daisuke Yabe
11th Asian Association for the Study of Diabetes Scientific Meeting   24 May 2019   
Views and trends on ICTs and NCDs: Experiences in Japan [Invited]
Daisuke Yabe
APEC Conference on Smart Healthcare for Non-communicable Diseases and Their Risk Factors Prevention and Control   30 Apr 2019   
Management of DKD with or without cardiovascular disease [Invited]
Daisuke Yabe
40th Annual Meeting of The Endocrine Society of the R.O.C.   31 Mar 2019   
New Evidences and Individualized Therapy of DPP-4 and SGLT2 inhibitors [Invited]
Daisuke Yabe
40th Annual Meeting of The Endocrine Society of the R.O.C.   30 Mar 2019   
Management of Aging and Comorbidity: The Role of DPP4 inhibitors in Asian Patients
Daisuke Yabe
40th Annual Meeting of The Endocrine Society of the R.O.C.   30 Mar 2019   
Macro Nutrients and Long-term Glucose-lowering Effects of DPP-4 Inhibitors in Individuals With Type 2 Diabetes [Invited]
Daisuke Yabe, Hitoshi Kuwata, Yutaka Seino
Asia Islet Biology & Incretin Symposium   4 Aug 2018   
Diabetes patients with coronary heart disease: Target and drug? Diabetes specialist’s perspectives [Invited]
Daisuke Yabe
Asia Pacific Society of Cardiology Congress 2018   19 May 2018   
Current status of type 2 diabetes in Japan [Invited]
Daisuke Yabe
Asia Pacific Society of Cardiology Congress 2018   18 May 2018   
Kenote: Cardiovascular Effects of Anti-diabetes Drugs: Focusing upon East Asians [Invited]
Daisuke Yabe
Asia Pacific Society of Cardiology Congress 2018   18 May 2018   
Meal sequence, incretin secretion and glycemic control [Invited]
Daisuke Yabe
Diabetes Preventing the Preventables 2018   6 May 2018   
Synergism through combination: which drugs should be used? [Invited]
Daisuke Yabe
World Diabetes Congress 2017   5 Dec 2017   
Diabetes definition, guidelines and diagnosis of diabetes [Invited]
Daisuke Yabe
Comprehensive education course for Asian diabetes educators   1 Oct 2017   
Blood pressure management guidelines in diabetes [Invited]
Daisuke Yabe
9th Scientific Meeting of the Asian Association for the Study of Diabetes   19 Jun 2017   
Journal of Diabetes Investigation Encouraging your submissions to int’l journals [Invited]
Daisuke Yabe
9th Scientific Meeting of the Asian Association for the Study of Diabetes   20 May 2017   
Diabetes Education and Care in Japan [Invited]
Daisuke Yabe
9th Scientific Meeting of the Asian Association for the Study of Diabetes   19 May 2017   
Incretins and incretin-related drugs in the management of type 2 diabetes: From Asian perspectives [Invited]
Daisuke Yabe
9th Scientific Meeting of the Asian Association for the Study of Diabetes   19 May 2017   
Incretin in the management of Asian type 2 diabetes: what is known and what remains to be investigated [Invited]
Daisuke Yabe
3rd Korea Japan Diabetes Forum   12 May 2017   
Diet and medication in the management of type 2 diabetes: Recent findings in an old couple [Invited]
Daisuke Yabe
5th Seoul International Congress of Endocrinology and Metabolism   28 Apr 2017   
Management of Nutrition and Metabolic Diseases in a Time of Disaster Urgent Actions and Long-term Plans [Invited]
Daisuke Yabe
11th International Diabetes Federation Western Pacific Region Congress/8th Asian Association for the Study of Diabetes Scientific Meeting   30 Oct 2016   
Use of GLP-1 receptor agonists in management of Asian type 2 diabetes: From perspectives of hypoglycemia and bodyweight control [Invited]
Daisuke Yabe
11th International Diabetes Federation Western Pacific Region Congress/8th Asian Association for the Study of Diabetes Scientific Meeting   29 Oct 2016   
Potential Cardiovascular Benefits of GLP-1 Agonists: from Incretin-Based Mechanisms to Cardiovascular Outcomes [Invited]
Daisuke Yabe
11th International Diabetes Federation Western Pacific Region Congress/7th Asian Association for the Study of Diabetes Scientific Meeting   27 Oct 2016   
Incretin Therapy and Hypoglycemia [Invited]
Daisuke Yabe
International Conference on Diabetes and Metabolism (ICDM) 2016   14 Oct 2016   
Incretin-based therapy for type 2 diabetes: Focus on East Asian perspectives and hypoglycemia [Invited]
Daisuke Yabe
7th Asian Association for the Study of Diabetes Scientific Meeting   22 Nov 2015   
Efficacy and Safety of Incretin-Based Therapies in Asian Clinical Use [Invited]
Daisuke Yabe
Incretin 2015   29 Jul 2015   
Diet and Medication in the Management of Type 2 Diabetes: Promising Fingsings in an Old Couple [Invited]
Daisuke Yabe
12th Asian Congress of Nutrition   17 May 2015   
Why are incretin-based therapies more efficient in East Asians [Invited]
Daisuke Yabe
10th International Diabetes Federation Western Pacific Region Congress/6th Asian Association for the Study of Diabetes Scientific Meeting   23 Nov 2014   
Debate: Incretin related therapies increase risk of acute pancreatitis or pancreatic cancer? - No [Invited]
Daisuke Yabe
5th the Asian Association for the Study of Diabetes Scientific Meeting, Symposium “AIBIS III”   9 Nov 2013   
Beyond Glycemic Control: From Gut to the Heart and More [Invited]
Daisuke Yabe
The Autumn Meeting of The Endocrine Society of the R.O.C. (Taiwan)   13 Oct 2013   
Education for Diabetes Self-Management [Invited]
Daisuke Yabe
Asia-Pacific Diabetes, Epidemiology and Education Training Course 2013   29 Aug 2013   
Diabetes Prevention Program: Japanese Experience [Invited]
Daisuke Yabe
Asia-Pacific Diabetes, Epidemiology and Education Training Course 2013   28 Aug 2013   
Pathophysiology and Treatment Strategies of Asian Type 2 Diabetes [Invited]
Daisuke Yabe
34th Annual Meeting of The Endocrine Society of the R.O.C. (Taiwan)   24 Mar 2013   
“Incretin Response to Nutrients and Anti-Diabetic Drugs in Human: Implications for Enhancing Incretin-Based Therapie [Invited]
Daisuke Yabe and Yutaka Seino
9th International Diabetes Federation-Western Pacific Region Congress/4th the Asian Association for the Study of Diabetes Scientific Meeting   26 Nov 2012   
Pathophysiology and Treatment Strategies of Asian Type 2 Diabetes [Invited]
Daisuke Yabe
9th International Diabetes Federation-Western Pacific Region Congress/4th the Asian Association for the Study of Diabetes Scientific Meeting   26 Nov 2012   
Incretin Based Therapy: Current Status and Future Prospects [Invited]
Daisuke Yabe
9th International Diabetes Federation-Western Pacific Region Congress/4th the Asian Association for the Study of Diabetes Scientific Meeting   25 Nov 2012   
Fresh Aspects of Acarbose in Diabetes Management [Invited]
Daisuke Yabe
The Future of Diabetes Management: A Patient-Centered Approach   Oct 2012   
GLP-1 Secretion in Japanese Patients with Type 2 Diabetes: Response to Anti-diabetic drugs, Metformin, Alpha-glycosidase Inhibitor or Sulfonylurea. [Invited]
Daisuke Yabe
The 25th Anniversary of the Discovery of GLP-1 Symposium   Sep 2012   
Incretin Secretion in Human: Response to Nutrients and Anti-diabetic Drugs [Invited]
Daisuke Yabe and Yutaka Seino
55th Annual Scientific Meeting of Japan Diabetes Society   May 2012   
インクレチン療法 総論 [Invited]
Daisuke Yabe
第46回日本糖尿病学会 糖尿病学の進歩   Mar 2012   
Diabetes Conversation Map Program: Learning experience to increase motivation for diabetes selfcare [Invited]
Daisuke Yabe
Advanced in Diabetology; The 46th Annual Postgraduate Course   Mar 2012   
Management of Nutrition and Metabolic Diseases in a Time of Disaster: Acute Actions and Long Term Plans [Invited]
Daisuke Yabe
47th US Japan Medical Science Program   Oct 2011   
Incretin-based therapies: Potential in Management of Asian Type 2 Diabetes. [Invited]
Daisuke Yabe
16th Japan-Korea Joint Symposium on Diabetes Mellitus   Oct 2011   
Incretin-Based Drugs; Potential and Problems in Asian Countries [Invited]
Daisuke Yabe
4th Asian Islet Biology and Incretin Study Group (AIBIS) Symposium, Plenary Leture   Jul 2011   
Efficacy of Incretin-Based Therapy in Japanese [Invited]
Daisuke Yabe
The 3rd Annual Meeting of the Asian Association for the Study of Diabetes   Jul 2011   
日本人2型糖尿病患者にインクレチン関連薬の有用性-日本人のインクレチン分泌と実臨床での効果を踏まえて [Invited]
矢部大介
第54回 日本糖尿病学会年次学術集会   May 2011   
日本人2型糖尿病に対するインクレチン関連薬の有用性と注意点 [Invited]
矢部大介
大阪府内科医会 特別講演会   Feb 2011   
日本糖尿病協会編『糖尿病連携手帳』~糖尿病地域連携のこれから~ [Invited]
矢部大介
第14回 日本病態栄養学会学術集会   Jan 2011   
Incretin-based therapies: Potential and Problems in Asian Countries [Invited]
Daisuke Yabe and Yutaka Seino
8th International Diabetes Federation-Western Pacific Region Congress   Nov 2010   
Characteristics of Japanese Type 2 Diabetes [Invited]
Daisuke Yabe and Yutaka Seino
2nd The Japan Science Technology Agency (JST)/The Danish Agency for Science, Technology and Innovation (DASTI) Symposium “Molecular Diabetology   Mar 2010   
An Accelerating Spread of Diabetes – Time to Tie Up in AASD (the Asian Association for the Study of Diabetes) [Invited]
Daisuke Yabe
26th Annual Convention of Diabetes Philippines   Nov 2009   
Incretin response in Japanese: Implications for reduced insulin secretory capacity of the Asians [Invited]
Daisuke Yabe and Yutaka Seino
15th Japan Korea Symposium on Diabetes Mellitus   Nov 2009   
Incretin response in Japanese patients with type 2 diabetes and healthy controls: Implications for reduced insulin secretory capacity of the Asians [Invited]
Daisuke Yabe
26th Annual Convention of Diabetes Philippines   Nov 2009   
Regulation of the Notch/RBP-J signaling by Mint, a functional homologue of Drosophila Hairless [Invited]
Daisuke Yabe
Workshop: Notch Signaling in Vertebrates Development and Disease   May 2006   
Regulation of Lymphocyte Development by Notch/RBP-J Signaling [Invited]
Daisuke Yabe and Tasuku Honjo
EMBO Workshop: Notch Signaling in Development and Cancer   Apr 2005   

Research Grants & Projects

 
Elucidation of molecular mechanisms controlling pancreatic b-cell proliferation by incretins
Ministry of Education, Culture, Sports, Science and Technology: Grant-in-aid for Scientific Research (C)
Project Year: Apr 2017 - Mar 2020    Investigator(s): Daisuke Yabe
Japan Association for Diabetes Education and Care: Grants for young researchers from Japan Association for Diabetes Education and Care
Project Year: 2015 - 2016
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2013 - 2015    Investigator(s): 矢部 大介
Japan Association for Diabetes Education and Care: Grants for young researchers from Japan Association for Diabetes Education and Care
Project Year: 2014 - 2015    Investigator(s): Daisuke Yabe
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2006 - 2007    Investigator(s): 矢部 大介
Notch受容体を介した細胞間相互作用による(A)神経系細胞分化制御機構1の解明、(B)記憶学習制御機構の解明を目的とするNotchシグナルが中枢神経系の構築ならびに機能発現に重要な役割を果たすことが強く示唆されているが、Notchシグナル分子の欠損マウスは胎生致死する為、生体内におけるNotchシグナルの解析は困難であった。本研究では、1)Notchシグナルの中枢分子RBP-Jを神経前駆細胞もしくは成熟神経細胞にて欠失させNotchシグナル阻害が神経発生ならびに神経機能に与える影響の解析...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(A))
Project Year: 2005 - 2007    Investigator(s): 矢部 大介
Notch受容体を介した細胞間相互作用による(A)神経系細胞分化制御機構の解明、(B)記憶学習制御機構の解明を目的とするNotchシグナルが中枢神経系の構築ならびに機能発現に重要な役割を果たすことが強く示唆されているが、Notchシグナル分子の欠損マウスは胎生致死する為、生体内におけるNotchシグナルの解析は困難であった。本研究では、1)Notchシグナルの中枢分子RBP-Jを神経前駆細胞もしくは成熟神経細胞にて欠失させNotchシグナル阻害が神経発生ならびに神経機能に与える影響の解析、...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2005    Investigator(s): 矢部 大介
Notch受容体を介した細胞間相互作用による神経系構築及び機能発現機構の解明を目的とする。特にNotchシグナルの破綻が記憶学習などの脳機能に与える影響を明らかにしたい。これまでの研究からNotchシグナルが中枢神経系の構築ならびに機能発現に重要な役割を果たすことが強く示唆される。が、Notchシグナルは胎生早期より広範な組織の発生に重大な役割を担うため、遺伝子欠損マウスを用いて生体内におけるNotchシグナルの役割を解明することは困難であった。さらに哺乳動物ゲノム上に4種類のNotch受...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2004 - 2004    Investigator(s): Tasuku HONJO
To elucidate the functions of Notch/RBP-J signaling in T cell development, we analyzed RBP-J-conditional knockout mice and reported that Notch/RBP-J signaling negatively regulates γ δ T cell generation, on the other hand, it promotes a β T cell ma...

Social Contribution

 
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[TV or radio appearance]  NHK World  Medical Frontiers  24 Oct 2017 - 24 Oct 2017