Daichi Onomura

Profile Information

Affiliation: School of Medicine, Faculty of Medicine, Jichi Medical University

Degree: 博士（医学）(Mar, 2021, 岡山大学)

Contact information: onomura.daichijichi.ac.jp
Researcher number: 00910697
J-GLOBAL ID: 202101019465399364
researchmap Member ID: R000021045

Research Areas

Life sciences / Virology / hepatitis virus,

Research History

Dec, 2022 - Present

Jichi Medical University
Apr, 2021 - Nov, 2022

Shimane University

Awards

Jun, 2018

Best Presentation Award, Elucidation of the mechanism of GPAM suppression by anti-HCVdrug ribavirin, Chugoku-Shikoku Virus Research Society

Daichi Onomura

Papers

Effects of Strain Differences, Humidity Changes, and Saliva Contamination on the Inactivation of SARS-CoV-2 by Ion Irradiation

Afifah Fatimah Azzahra Ahmad Wadi, Daichi Onomura, Hirokazu Funamori, Mst Mahmuda Khatun, Shunpei Okada, Hisashi Iizasa, Hironori Yoshiyama

Viruses, 16(4) 520-520, Mar 28, 2024
TRIM26 positively affects hepatitis B virus replication by inhibiting proteasome-dependent degradation of viral core protein.

Yuki Nakaya, Tsutomu Nishizawa, Hironori Nishitsuji, Hiromi Morita, Tomoko Yamagata, Daichi Onomura, Kazumoto Murata

Scientific reports, 13(1) 13584-13584, Aug 21, 2023
Development of Epstein-Barr virus-associated gastric cancer: Infection, inflammation, and oncogenesis.

Hisashi Iizasa, Andy Visi Kartika, Sintayehu Fekadu, Shunpei Okada, Daichi Onomura, Afifah Fatimah Azzahra Ahmad Wadi, Mosammat Mahmuda Khatun, Thin Myat Moe, Jun Nishikawa, Hironori Yoshiyama

World journal of gastroenterology, 28(44) 6249-6257, Nov 28, 2022
ブレオマイシン類似体であるゼオシンは、EBV陽性胃がんの細胞死を優先的に導く。(Zeocin, a bleomycin analog, induces preferential EBV-positive gastric cancer cell death.)

ワイ・アウンヒョウ, 飯笹久, モウ・シンミャット, カトゥン・マストマスムダ, 小野村大地, 岡田俊平, 吉山裕規

日本癌学会総会記事, 81回 E-1014, Sep, 2022
B型肝炎ウイルスの複製を抑制する宿主マイクロRNAの同定(Identification of a host microRNA that suppresses replication of hepatitis B virus.)

小野村大地, 飯笹久, Liu Yuxing, Fatimah Afifah, 岡田俊平, 吉山裕規

日本癌学会総会記事, 81回 P-1040, Sep, 2022
Identification of ribavirin-responsive cis-elements for GPAM suppression in the GPAM genome.

Daichi Onomura, Shinya Satoh, Youki Ueda, Hiromichi Dansako, Nobuyuki Kato

Biochemical and biophysical research communications, 533(1) 148-154, Nov 26, 2020
Ribavirin-induced down-regulation of CCAAT/enhancer-binding protein α leads to suppression of lipogenesis.

Shinya Satoh, Daichi Onomura, Youki Ueda, Hiromichi Dansako, Masao Honda, Shuichi Kaneko, Nobuyuki Kato

The Biochemical journal, 476(1) 137-149, Jan 15, 2019
Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor α.

Shinya Satoh, Kyoko Mori, Daichi Onomura, Youki Ueda, Hiromichi Dansako, Masao Honda, Shuichi Kaneko, Masanori Ikeda, Nobuyuki Kato

Hepatology communications, 1(6) 550-563, Aug, 2017

Misc.

EBウイルスの胃上皮細胞への感染と不死化

小野村大地, Afifa Fatimah, 吉山裕規

EBウイルス関連胃癌改訂第２版, Dec, 2022 Peer-reviewedLead author

Presentations

コロナ放電デバイスによるSARS-CoV-2不活化効果の検証

小野村大地, 飯笹久, 岡田俊平, Afifah Fatimah, 吉山裕規

日本ウイルス学会学術集会, Nov 13, 2022
Zeocin, a bleomycin analog, induces preferential EBV-positive gastric cancer cell death

Aung phyo Wai, Hisashi Iizasa, Thin M. Moe, Mst M. Khatun, Daichi Onomura, Shunpei Okada, Hironori Yoshiyama

Sep 29, 2022
Identification of a host microRNA that suppresses replication of hepatitis B virus

Daichi Onomura, Hisashi Iizasa, Yuxing Liu, Afifah Fatimah, Shunpei Okada, Hironori Yoshiyama

Sep 29, 2022
転写因子C/EBPαを標的にした中性脂肪合成阻害剤の探索

佐藤伸哉, 小野村大地, 渡士幸一, 上田優輝, 團迫浩方, 本多政夫, 金子周一, 鈴木哲郎, 加藤宣之

日本分子生物学会
C/EBPα によるトリグリセリド合成酵素遺伝子GPAM の発現制御メカニズムの解析

小野村大地, 佐藤伸哉, 上田優輝, 團迫浩方, 加藤宣之

第 43 回日本分子生物学会, Dec, 2020
抗 HCV 薬リバビリンによる GPAM 発現抑制機序の解析

小野村大地, 佐藤伸哉, 上田優輝, 團迫浩方, 加藤宣之

第 42 回日本分子生物学会, Dec, 2019
抗ウイルス薬リバビリンによる転写因子C/EBPαタンパク質の分解亢進は細胞内中性脂肪量を低下させる

佐藤伸哉, 小野村大地, 上田優輝, 團迫浩方, 本多政夫, 金子周一, 加藤宣之

第42回日本分子生物学会, Dec, 2019
抗 HCV 薬リバビリンによる GPAM 発現抑制機序の解析

小野村大地, 佐藤伸哉, 團迫浩方, 上田優輝, 加藤宣之

第3回中性脂肪学会学術集会, Oct, 2019
転写因子C/EBPαを標的にした中性脂肪合成阻害剤の探索

佐藤伸哉, 小野村大地, 渡士幸一, 上田優輝, 團迫浩方, 本多政夫, 金子周一, 加藤宣之

第3回中性脂肪学会学術集会, Oct, 2019
Drug screening for suppression of lipogenesis through downregulation of C/EBPα.

Oct, 2018
抗 HCV 薬リバビリンによる中性脂質合成抑制機序の解明

小野村大地

肝炎ウイルス研修会, Mar, 2018
Downregulation of C/EBPα by anti-HCV drug ribavirin leads to the suppression of triglyceride synthesis pathway.

Oct, 2017
抗HCV薬リバビリンの脂質生合成抑制機序の解明

佐藤伸哉, 小野村大地, 上田優輝, 團迫浩方, 池田正徳, 加藤宣之

第32回中国四国ウイルス研究会, Jun, 2017
Mechanism for suppression of hepatic lipogenesis by snit-HCV drug ribavirin.

佐藤伸哉, 小野村大地, 上田優輝, 團迫浩方, 本田政夫, 金子周一, 池田正徳, 加藤宣之

第64回日本ウイルス学会, Oct, 2016
核酸アナログ型抗 HCV 薬による AMPK 活性への影響

小野村大地, 佐藤伸哉, 上田優輝, 團迫浩方, 加藤宣之

第 31 回中国四国ウイルス研究会, Jul, 2016

Teaching Experience

Jan, 2022 - Nov, 2022

Bacteriology (Shimane University)
Oct, 2021 - Nov, 2022

Microbiology and immunology (The University of Shimane)
May, 2021 - Nov, 2022

Microbiology practice (Shimane University)
Apr, 2021 - Nov, 2022

Virology (Shimane University)

Professional Memberships

Sep, 2022 - Present

日本癌学会
Sep, 2019 - Present

The Molecular Biology Society of Japan
Aug, 2019 - Present

Society for Triglyceride Biology and Medicine
Jun, 2015 - Present

中国四国ウイルス研究会
Jun, 2015 - Present

The Japanese Society For Virology

Research Projects

B型肝炎ウイルスの増殖を調節する新しい宿主micro RNAの研究

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2024

小野村大地
Importance of cell differentiation and lytic viral replication in EBV-related epithelial tumor formation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2021 - 2023
Research on the mechanism of hepatocarcinogenesis by long-term replication of hepatitis virus

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Kato Nobuyuki, SEJIMA Hiroe, KOKU Irin, ONOMURA Daichi, HIRAMOTO Hiroki

Profile Information

Research Areas

Research History

Awards

Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

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