1999年6月
Atomic force microscopic observation of three-dimensional morphological changes of neurons where stimulated by a neurotransmitter
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS
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- 巻
- 38
- 号
- 6B
- 開始ページ
- 3940
- 終了ページ
- 3945
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1143/JJAP.38.3940
- 出版者・発行元
- JAPAN J APPLIED PHYSICS
As the first step in the study df morphological changes in neurons associated with their functional changes, we applied atomic force microscopy (AFM) for the observation of fine three-dimensional morphological changes in rat cerebellar granule cells stimulated by an agonist of glutamate receptors, N-methyl-D-aspartate (NMDA). The AFM revealed that NMDA changed the cross-sections of cell bodies from a trapezoid-like form to a triangle-like form within a minute. The fine hill-like structures on the top surfaces of the cell bodies became wider during the same period. These results were suggested to be induced by the depolymerization; of filamentous actin triggered by the entry of Ca2+ via cation channels complexed with the activated NMDA receptors.
- リンク情報
- ID情報
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- DOI : 10.1143/JJAP.38.3940
- ISSN : 0021-4922
- CiNii Articles ID : 30021833791
- Web of Science ID : WOS:000081576700031