三木 大樹

J-GLOBALへ         更新日: 19/09/11 02:47
 
アバター
研究者氏名
三木 大樹
 
ミキ ダイキ
eメール
daikimikihiroshima-u.ac.jp
所属
広島大学
学位
博士(医学)(広島大学)
科研費研究者番号
10584592
ORCID ID
0000-0002-6505-9826

経歴

 
2000年4月
 - 
2002年3月
広島大学医学部附属病院 医員(研修医)
 
2002年4月
 - 
2005年3月
三菱三原病院 (内科)医師
 
2005年4月
 - 
2006年3月
広島大学病院 医員
 
2008年10月
 - 
2010年3月
東京大学医科学研究所 ヒトゲノム解析センター リサーチ・アシスタント
 
2010年4月
 - 
2014年7月
理化学研究所ゲノム医科学研究センター 消化器疾患研究チーム 研究員
 

学歴

 
1994年4月
 - 
2000年3月
広島大学 医学部 医学科
 
2006年4月
 - 
2010年3月
広島大学 大学院医歯薬学総合研究科 博士課程創生医科学専攻
 

委員歴

 
2013年12月
 - 
2017年3月
日本肝臓学会  西部会評議員
 
2017年4月
 - 
2018年3月
日本肝臓学会  西部会評議員
 
2018年4月
 - 
2019年3月
日本肝臓学会  西部会評議員
 
2019年4月
 - 
2020年3月
日本肝臓学会  西部会評議員
 

受賞

 
2013年11月
The American Association for the Study of Liver Diseases Presidential Poster of Distinction HLA-DQ confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study
 
2012年10月
日本肝臓学会 冠Award(第5回CHUGAI Award) C型慢性肝炎からの肝発癌に関する宿主因子(遺伝的背景)の探索
 
2011年11月
The American Association for the Study of Liver Diseases Young Investigator Liver Cancer Research Award A genome-wide association study identified a novel susceptibility locus for hepatocellular carcinoma in chronic hepatitis C virus carriers
 
2011年10月
日本癌学会 日本癌学会奨励賞 日本人と韓国人の肺腺癌発症に関連するTP63の一塩基多型の同定
 
2011年6月
広島大学医学部医学科同窓会 第14回広仁会基礎医学研究賞 ゲノムワイド関連解析による日本人(又は東アジア人)における肝疾患感受性遺伝子及び薬剤応答性(効果,副作用)関連遺伝子の同定
 
2008年6月
日本肝臓学会 優秀演題賞 HCV感染モデルマウスを用いたHCV CoreおよびISDR領域のアミノ酸変異とウイルス感染性の検討
 

論文

 
Osawa M, Uchida T, Imamura M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Ishida Y, Tateno C, Miyayama Y, Hijikata M, Chayama K.
Journal of General Virology   100(7) 1123-1131   [査読有り]
Hiramatsu, Akira; Aikata, Hiroshi; Uchikawa, Shinsuke; Ohya, Kazuki; Kodama, Kenichiro; Nishida, Yuno; Daijo, Kana; Osawa, Mitsutaka; Teraoka, Yuji; Honda, Fumi; Inagaki, Yuki; Morio, Kei; Morio, Reona; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Yamauchi, Masami; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Tanaka, Junko; Chayama, Kazuaki
HEPATOLOGY COMMUNICATIONS   3(3) 348-355   2019年3月   [査読有り]
Although the effect of levocarnitine (L-carnitine) on hyperammonemia has been reported in patients with liver cirrhosis (LC), its effect on sarcopenia remains to be elucidated. We assessed the effects of L-carnitine on sarcopenia in patients with ...
Tsushima, Ken; Tsuge, Masataka; Hiraga, Nobuhiko; Uchida, Takuro; Murakami, Eisuke; Makokha, Grace Naswa; Kurihara, Mio; Nomura, Motonobu; Hiyama, Yuichi; Fujino, Hatsue; Ono, Atsushi; Nakahara, Takashi; Yamauchi, Masami; Abe-Chayama, Hiromi; Kawaoka, Tomokazu; Miki, Daiki; Imamura, Michio; Aikata, Hiroshi; Hayes, Clair Nelson; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   54(7) 650-659   2019年7月   [査読有り]
Background and aimsThe clinical course and responsiveness to antiviral treatments differs among hepatitis B virus (HBV) genotypes. However, the cause of these differences is unclear. In the present study, we compared mRNA expression profiles in hu...
Nagaoki, Yuko; Imamura, Michio; Nishida, Yuno; Daijo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Kawakami, Yoshiiku; Miki, Daiki; Hiyama, Yuichi; Ochi, Hidenori; Chayama, Kazuaki; Aikata, Hiroshi
JOURNAL OF MEDICAL VIROLOGY   91(4) 650-658   2019年4月   [査読有り]
Background and Aim To examine the effect on recurrence and survival of treatment by interferon (IFN)-free direct-acting antivirals (DAA) for patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) who underwent primary cura...
Osawa, Mitsutaka; Imamura, Michio; Teraoka, Yuji; Uchida, Takuro; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Ono, Atsushi; Murakami, Eisuke; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, C. Nelson; Chayama, Kazuaki; Aimitsu, Shiomi; Azakami, Takahiro; Kamada, Koji; Katamura, Yoshio; Kawakami, Hiroiku; Kawakami, Yoshiiku; Kimura, Takashi; Takahashi, Shoichi; Tsuji, Keiji; Takaki, Shintaro; Mori, Nami; Nagaoki, Yuko; Moriya, Takashi; Yamaguchi, Shuji
JOURNAL OF GASTROENTEROLOGY   54(3) 291-296   2019年3月   [査読有り]
BackgroundCombination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy of the therapy for failures to prior direct-acting antiviral (DAA) reg...
Tsuge, Masataka; Hiraga, Nobuhiko; Zhang, Yizhou; Yamashita, Misa; Sato, Ojiro; Oka, Naoya; Shiraishi, Kanma; Izaki, Yu f; Makokha, Grace Naswa; Uchida, Takuro; Kurihara, Mio; Nomura, Motonobu; Tsushima, Ken; Nakahara, Takashi; Murakami, Eisuke; Abe-Chayama, Hiromi; Kawaoka, Tomokazu; Miki, Daiki; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Hayes, C. Nelson; Fujita, Takashi; Chayama, Kazuaki
VIROLOGY   525 48-61   2018年12月   [査読有り]
The events in the immune response to hepatitis B virus (HBV) remain unclear. We analyzed the direct influence of HBV on gene expression in human hepatocytes under immunodeficient conditions using a human hepatocyte chimeric mouse model. HBV-infect...
Morio K, Imamura M, Kawakami Y, Nakamura Y, Hatooka M, Morio R, Fujino H, Nakahara T, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Miki D, Ochi H, Katamura Y, Arataki K, Moriya T, Ito H, Tsuji K, Kohno H, Waki K, Tamura T, Nakamura T, Chayama K; Hiroshima Liver Study Group.
Journal of Medical Virology   90(12) 1834-1840   [査読有り]
Nomura M, Tsuge M, Uchida T, Hiraga N, Kurihara M, Tsushima K, Fujino H, Nakahara T, Murakami E, Abe-Chayama H, Kawaoka T, Miki D, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Ochi H, Zhang Y, Makokha GN, Hayes CN, Tanaka S, Chayama K.
Journal of Viral Hepatitis   25(12) 1555-1564   [査読有り]
Teraoka, Yuji; Uchida, Takuro; Imamura, Michio; Hiraga, Nobuhiko; Osawa, Mitsutaka; Kan, Hiromi; Saito, Yuhei; Tsuge, Masataka; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   99(8) 1058-1065   2018年   [査読有り]
Tatsukawa, Yumiko; Tsuge, Masataka; Kawakami, Yoshiiku; Hiyama, Yuichi; Murakami, Eisuke; Kurihara, Mio; Nomura, Motonobu; Tsushima, Ken; Uchida, Takuro; Nakahara, Takashi; Miki, Daiki; Kawaoka, Tomokazu; Abe-Chayama, Hiromi; Imamura, Michio; Aikata, Hiroshi; Ochi, Hidenori; Hayes, C. Nelson; Kawakami, Hiroiku; Chayama, Kazuaki
ANTIVIRAL THERAPY   23(8) 639-646   2018年   [査読有り]
Background: Although pegylated interferon (PEG-IFN) and nucleotide/nucleoside analogue (NA) combination therapy is considered to be optimal for accelerating serum hepatitis B surface antigen (HBsAg) reduction, the effect is limited, and the best a...
Teraoka, Yuji; Uchida, Takuro; Imamura, Michio; Osawa, Mitsutaka; Tsuge, Masataka; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   500(2) 152-157   2018年6月   [査読有り]
Yamauchi, Masami; Urabe, Yuji; Ono, Atsushi; Miki, Daiki; Ochi, Hidenori; Chayama, Kazuaki
INTERNATIONAL JOURNAL OF CANCER   142(7) 1418-1426   2018年4月   [査読有り]
Nagaoki, Yuko; Aikata, Hiroshi; Daijyo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Hatooka, Masahiro; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(4) 264-274   2018年   [査読有り]
Kurihara M, Tsuge M, Murakami E, Mori N, Ohishi W, Uchida T, Fujino H, Nakahara T, Abe-Chayama H, Kawaoka T, Miki D, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Ochi H, Zhang Y, Makokha GN, Hayes CN, Chayama K.
Antiviral Therapy   23(3) 239-248   [査読有り]
Nagaoki, Yuko; Imamura, Michio; Aikata, Hiroshi; Daijo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Hatooka, Masahiro; Morio, Reona; Morio, Kei; Kan, Hiromi; Fujino, Hatsue; Kobayashi, Tomoki; Masaki, Keiichi; Ono, Atsushi; Nakahara, Takashi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Kawakami, Yoshiiku; Hayes, C. Nelson; Miki, Daiki; Ochi, Hidenori; Chayama, Kazuaki
PLOS ONE   12(8) e0182710-e0182710   2017年8月   [査読有り]
Nakahara, Takashi; Hyogo, Hideyuki; Ono, Atsushi; Nagaoki, Yuko; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiraga, Nobuhiko; Hayes, Clair Nelson; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Abe-Chayama, Hiromi; Furusho, Hisako; Shintani, Tomoaki; Kurihara, Hidemi; Miyauchi, Mutsumi; Takata, Takashi; Arihiro, Koji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(2) 269-280   2018年   [査読有り]
Uchida, Takuro; Imamura, Michio; Hayes, C. Nelson; Hiraga, Nobuhiko; Kan, Hiromi; Tsuge, Masataka; Abe-Chayama, Hiromi; Zhang, Yizhou; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   61(9) e00725-17-e00725-17   2017年   [査読有り]
Kan, Hiromi; Imamura, Michio; Kawakami, Yoshiiku; Daijo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Morio, Kei; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Aikata, Hiroshi; Hayes, Clair Nelson; Miki, Daiki; Ochi, Hidenori; Honda, Yoji; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   89(11) 1963-1972   2017年   [査読有り]
Masuda, Kazuhiko; Ono, Atsushi; Aikata, Hiroshi; Kawaoka, Tomokazu; Hayes, C. Nelson; Teraoka, Yuji; Daijo, Kana; Nakamura-Inagaki, Yuki; Morio, Kei; Fujino, Hatsue; Kan, Hiromi; Uchida, Takuro; Masaki, Keiichi; Kobayashi, Tomoki; Nakahara, Takashi; Makokha, Grace Naswa; Zhang, Yizhou; Nagaoki, Yuko; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Abe-Chayama, Hiromi; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(1) 107-118   2018年   [査読有り]
Tsuge, Masataka; Uchida, Takuro; Hiraga, Nobuhiko; Kan, Hiromi; Makokha, Grace Naswa; Abe-Chayama, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Hayes, C. Nelson; Shimozono, Rieko; Iwamura, Tomokatsu; Narumi, Hideki; Suzuki, Tomohiko; Kainoh, Mie; Taniguchi, Tadatsugu; Chayama, Kazuaki
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   61(6) e00183-e00183   2017年   [査読有り]
Uchida, Takuro; Imamura, Michio; Kan, Hiromi; Hiraga, Nobuhiko; Hayes, C. Nelson; Tsuge, Masataka; Abe-Chayama, Hiromi; Aikata, Hiroshi; Makokha, Grace Naswa; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   98(5) 1040-1047   2017年   [査読有り]
Morio, Reona; Imamura, Michio; Kawakami, Yoshiiku; Morio, Kei; Kobayashi, Tomoki; Yokoyama, Satoe; Kimura, Yuki; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Hayes, C. Nelson; Aikata, Hiroshi; Takahashi, Shoichi; Miki, Daiki; Ochi, Hidenori; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   52(4) 504-511   2017年   [査読有り]
Nakamura, Yuki; Imamura, Michio; Kawakami, Yoshiiku; Teraoka, Yuji; Daijo, Kana; Honda, Fumi; Morio, Kei; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, C. Nelson; Miki, Daiki; Ochi, Hidenori; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   89(4) 665-671   2017年   [査読有り]
Morio, Kei; Imamura, Michio; Kawakami, Yoshiiku; Morio, Reona; Kobayashi, Tomoki; Yokoyama, Satoe; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Makokha, Grace Naswa; Hayes, C. Nelson; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Honda, Yoji; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32(3) 645-650   2017年   [査読有り]
Mori, Nami; Imamura, Michio; Kawakami, Yoshiiku; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Hayes, C. Nelson; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Honda, Yohji; Takaki, Shintaro; Tsuji, Keiji; Chayama, Kazuaki
HEPATOLOGY RESEARCH   47(3) E5-E13   2017年   [査読有り]
Kan, Hiromi; Imamura, Michio; Uchida, Takuro; Hiraga, Nobuhiko; Hayes, C. Nelson; Tsuge, Masataka; Abe, Hiromi; Aikata, Hiroshi; Makokha, Grace Naswa; Chowdhury, Sajeda; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
JOURNAL OF INFECTIOUS DISEASES   214(11) 1687-1694   2016年12月   [査読有り]
Tsuge, Masataka; Hiraga, Nobuhiko; Uchida, Takuro; Kan, Hiromi; Miyaki, Eisuke; Masaki, Keiichi; Ono, Atsushi; Nakahara, Takashi; Abe-Chayama, Hiromi; Zhang, Yizhou; Naswa, Makokha Grace; Kawaoka, Tomokazu; Miki, Daiki; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Hayes, C. Nelson; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   51(11) 1073-1080   2016年   [査読有り]
Tsuge, Masataka; Hiramatsu, Akira; Shinohara, Fumi; Nakano, Norihito; Nakamura, Yuki; Hatooka, Masahiro; Morio, Kei; Morio, Reona; Kan, Hiromi; Fujino, Hatsue; Uchida, Takuro; Kobayashi, Tomoki; Fukuhara, Takayuki; Masaki, Keiichi; Nakahara, Takashi; Ono, Atsushi; Nagaoki, Yuko; Miki, Daiki; Kawaoka, Tomokazu; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Nelson Hayes, C.; Chayama, Kazuaki
HEPATOLOGY RESEARCH   46(9) 944-948   2016年   [査読有り]
Kan, Hiromi; Hiraga, Nobuhiko; Imamura, Michio; Hayes, C. Nelson; Uchida, Takuro; Miyaki, Eisuke; Tsuge, Masataka; Abe, Hiromi; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
ANTIVIRAL THERAPY   21(4) 307-315   2016年   [査読有り]
Nagaoki, Yuko; Aikata, Hiroshi; Nakano, Norihito; Shinohara, Fumi; Nakamura, Yuki; Hatooka, Masahiro; Morio, Kei; Kan, Hiromi; Fujino, Hatsue; Kobayashi, Tomoki; Fukuhara, Takayuki; Masaki, Keiichi; Ono, Atsushi; Nakahara, Takashi; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Takahashi, Shoichi; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31(5) 1009-1015   2016年   [査読有り]
Murakami, Eisuke; Tsuge, Masataka; Hiraga, Nobuhiko; Kan, Hiromi; Uchida, Takuro; Masaki, Keiichi; Nakahara, Takashi; Ono, Atsushi; Miki, Daiki; Kawaoka, Tomokazu; Abe, Hiromi; Imamura, Michio; Aikata, Hiroshi; Ochi, Hidenori; Hayes, C. Nelson; Akita, Tomoyuki; Tanaka, Junko; Chayama, Kazuaki
JOURNAL OF INFECTION   72(1) 91-102   2016年   [査読有り]
Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Toshishige, Masaaki; Tokuyama, Takehito; Matsumura, Hiroya; Kawazoe, Hiroshi; Tomomori, Shunsuke; Sairaku, Akinori; Watanabe, Yoshikazu; Ikenaga, Hiroki; Motoda, Chikaaki; Suenari, Kazuyoshi; Hayashida, Yasufumi; Miki, Daiki; Oda, Nozomu; Kishimoto, Shinji; Oda, Noboru; Yoshida, Yukihiko; Tashiro, Satoshi; Chayama, Kazuaki; Kihara, Yasuki
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY   9(1) e003436-e003436   2016年   [査読有り]
Akamatsu, Sakura; Hayes, C. Nelson; Ochi, Hidenori; Uchida, Takuro; Kan, Hiromi; Murakami, Eisuke; Abe, Hiromi; Tsuge, Masataka; Miki, Daiki; Akiyama, Rie; Hiraga, Nobuhiko; Imamura, Michio; Aikata, Hiroshi; Kawaoka, Tomokazu; Kawakami, Yoshiiku; Chayama, Kazuaki
JOURNAL OF HEPATOLOGY   63(3) 554-563   2015年   [査読有り]
Ono, Atsushi; Fujimoto, Akihiro; Yamamoto, Yujiro; Akamatsu, Sakura; Hiraga, Nobuhiko; Imamura, Michio; Kawaoka, Tomokazu; Tsuge, Masataka; Abe, Hiromi; Hayes, C. Nelson; Miki, Daiki; Furuta, Mayuko; Tsunoda, Tatsuhiko; Miyano, Satoru; Kubo, Michiaki; Aikata, Hiroshi; Ochi, Hidenori; Kawakami, Yoshi-iku; Arihiro, Koji; Ohdan, Hideki; Nakagawa, Hidewaki; Chayama, Kazuaki
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY   1(5) 516-534   2015年   [査読有り]
Yoshimi, Satoshi; Ochi, Hidenori; Murakami, Eisuke; Uchida, Takuro; Kan, Hiromi; Akamatsu, Sakura; Hayes, C. Nelson; Abe, Hiromi; Miki, Daiki; Hiraga, Nobuhiko; Imamura, Michio; Aikata, Hiroshi; Chayama, Kazuaki
PLOS ONE   10(6) e0130022-e0130022   2015年6月   [査読有り]
Akamatsu, Sakura; Hayes, C. Nelson; Tsuge, Masataka; Miki, Daiki; Akiyama, Rie; Abe, Hiromi; Ochi, Hidenori; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Aikata, Hiroshi; Kawaoka, Tomokazu; Kawakami, Yoshiiku; Ohishi, Waka; Chayama, Kazuaki
JOURNAL OF INFECTION   70(3) 273-287   2015年   [査読有り]
Honda, Yohji; Takahashi, Shoichi; Zhang, Yizhou; Ono, Atsushi; Murakami, Eisuke; Shi, Niu; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiraga, Nobuhiko; Abe, Hiromi; Ochi, Hidenori; Imamura, Michio; Aikata, Hiroshi; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30(3) 619-627   2015年   [査読有り]
Kosaka, Keiichi; Imamura, Michio; Hayes, C. Nelson; Abe, Hiromi; Hiraga, Nobuhiko; Yoshimi, Satoshi; Murakami, Eisuke; Kawaoka, Tomokazu; Tsuge, Masataka; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Matsui, Hirotaka; Kanai, Akinori; Inaba, Toshiya; Chayama, Kazuaki
JOURNAL OF VIRAL HEPATITIS   22(2) 158-165   2015年   [査読有り]
Akamatsu, Sakura; Hayes, C. Nelson; Tsuge, Masataka; Murakami, Eisuke; Hiraga, Nobuhiko; Abe, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Chayama, Kazuaki
JOURNAL OF VIRAL HEPATITIS   22(2) 166-174   2015年   [査読有り]
Fujino, Hatsue; Imamura, Michio; Nagaoki, Yuko; Kawakami, Yoshiiku; Abe, Hiromi; Hayes, C. Nelson; Kan, Hiromi; Fukuhara, Takayuki; Kobayashi, Tomoki; Masaki, Keiichi; Ono, Atsushi; Nakahara, Takashi; Honda, Youji; Naeshiro, Noriaki; Urabe, Ayako; Yokoyama, Satoe; Miyaki, Daisuke; Murakami, Eisuke; Kawaoka, Tomokazu; Hiraga, Nobuhiko; Tsuge, Masataka; Hiramatsu, Akira; Hyogo, Hideyuki; Aikata, Hiroshi; Takahashi, Shoichi; Miki, Daiki; Ochi, Hidenori; Ohishi, Waka; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   49(12) 1548-1556   2014年   [査読有り]
Tanimine, Naoki; Tanaka, Yuka; Kobayashi, Tsuyoshi; Tashiro, Hirotaka; Miki, Daiki; Imamura, Michio; Aikata, Hiroshi; Tanaka, Junko; Chayama, Kazuaki; Ohdan, Hideki
CANCER IMMUNOLOGY RESEARCH   2(12) 1142-1147   2014年   [査読有り]
Kawaoka, Tomokazu; Takahashi, Shoichi; Tatsukawa, Yumiko; Hiramatsu, Akira; Hiraga, Nobuhiko; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Ishiyama, Kouhei; Ide, Kentaro; Tashiro, Hirotaka; Ohdan, Hideki; Chayama, Kazuaki
HEPATOLOGY RESEARCH   44(12) 1259-1264   2014年   [査読有り]
Kohno, Tomohiko; Tsuge, Masataka; Murakami, Eisuke; Hiraga, Nobuhiko; Abe, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Hayes, C. Nelson; Chayama, Kazuaki
JOURNAL OF VIRAL HEPATITIS   21(9) E89-E97   2014年   [査読有り]
Ochi, Hidenori; Miki, Daiki; Hayes, C. Nelson; Abe, Hiromi; Hayashida, Yasufumi; Kubo, Michiaki; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   95(6) 1297-1306   2014年   [査読有り]
Murakami, Eisuke; Imamura, Michio; Hayes, C. Nelson; Abe, Hiromi; Hiraga, Nobuhiko; Honda, Yoji; Ono, Atsushi; Kosaka, Keiichi; Kawaoka, Tomokazu; Tsuge, Masataka; Aikata, Hiroshi; Takahashi, Shoichi; Miki, Daiki; Ochi, Hidenori; Matsui, Hirotaka; Kanai, Akinori; Inaba, Toshiya; McPhee, Fiona; Chayama, Kazuaki
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   58(4) 2105-2112   2014年   [査読有り]
Miki, Daiki; Ochi, Hidenori; Takahashi, Atsushi; Hayes, C. Nelson; Urabe, Yuji; Abe, Hiromi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Takahashi, Shoichi; Akuta, Norio; Suzuki, Fumitaka; Ikeda, Kenji; Kumada, Hiromitsu; Karino, Yoshiyasu; Toyota, Joji; Tsunoda, Tatsuhiko; Kubo, Michiaki; Kamatani, Naoyuki; Nakamura, Yusuke; Chayama, Kazuaki
PLOS ONE   8(12) e84226-e84226   2013年12月   [査読有り]
Kosaka, Keiichi; Hiraga, Nobuhiko; Imamura, Michio; Yoshimi, Satoshi; Murakami, Eisuke; Nakahara, Takashi; Honda, Yoji; Ono, Atsushi; Kawaoka, Tomokazu; Tsuge, Masataka; Abe, Hiromi; Hayes, C. Nelson; Miki, Daiki; Aikata, Hiroshi; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Yoshizato, Katsutoshi; Sasaki, Tamito; Chayama, Kazuaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   441(1) 230-235   2013年11月   [査読有り]
Tsuge, Masataka; Murakami, Eisuke; Imamura, Michio; Abe, Hiromi; Miki, Daiki; Hiraga, Nobuhiko; Takahashi, Shoichi; Ochi, Hidenori; Hayes, C. Nelson; Ginba, Hiroyuki; Matsuyama, Kazuhiro; Kawakami, Hiroiku; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   48(10) 1188-1204   2013年   [査読有り]
Abe, Hiromi; Hayes, C. Nelson; Hiraga, Nobuhiko; Imamura, Michio; Tsuge, Masataka; Miki, Daiki; Takahashi, Shoichi; Ochi, Hidenori; Chayama, Kazuaki
AMERICAN JOURNAL OF GASTROENTEROLOGY   108(9) 1464-1472   2013年   [査読有り]
茶山一彰、越智秀典、三木大樹
日本消化器病学会雑誌   110(9) 1577-1590   2013年9月   [査読有り][招待有り]
Lange, Christian M.; Miki, Daiki; Ochi, Hidenori; Nischalke, Hans-Dieter; Bojunga, Joerg; Bibert, Stephanie; Morikawa, Kenichi; Gouttenoire, Jerome; Cerny, Andreas; Dufour, Jean-Francois; Gorgievski-Hrisoho, Meri; Heim, Markus H.; Malinverni, Raffaele; Muellhaupt, Beat; Negro, Francesco; Semela, David; Kutalik, Zoltan; Mueller, Tobias; Spengler, Ulrich; Berg, Thomas; Chayama, Kazuaki; Moradpour, Darius; Bochud, Pierre-Yves
PLOS ONE   8(5) e64053-e64053   2013年5月   [査読有り]
Arataki, Keiko; Hayes, C. Nelson; Akamatsu, Sakura; Akiyama, Rie; Abe, Hiromi; Tsuge, Masataka; Miki, Daiki; Ochi, Hidenori; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Aikata, Hiroshi; Kawaoka, Tomokazu; Kawakami, Hiroiku; Ohishi, Waka; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   85(5) 789-798   2013年   [査読有り]
Urabe, Yuji; Ochi, Hidenori; Kato, Naoya; Kumar, Vinod; Takahashi, Atsushi; Muroyama, Ryosuke; Hosono, Naoya; Otsuka, Motoyuki; Tateishi, Ryosuke; Lo, Paulisally Hau Yi; Tanikawa, Chizu; Omata, Masao; Koike, Kazuhiko; Miki, Daiki; Abe, Hiromi; Kamatani, Naoyuki; Toyota, Joji; Kumada, Hiromitsu; Kubo, Michiaki; Chayama, Kazuaki; Nakamura, Yusuke; Matsuda, Koichi
JOURNAL OF HEPATOLOGY   58(5) 875-882   2013年   [査読有り]
Lo, Paulisally Hau Yi; Urabe, Yuji; Kumar, Vinod; Tanikawa, Chizu; Koike, Kazuhiko; Kato, Naoya; Miki, Daiki; Chayama, Kazuaki; Kubo, Michiaki; Nakamura, Yusuke; Matsuda, Koichi
PLOS ONE   8(4) e61279-e61279   2013年4月   [査読有り]
Nakano, Yukiko; Chayama, Kazuaki; Ochi, Hidenori; Toshishige, Masaaki; Hayashida, Yasufumi; Miki, Daiki; Hayes, C. Nelson; Suzuki, Hidekazu; Tokuyama, Takehito; Oda, Noboru; Suenari, Kazuyoshi; Uchimura-Makita, Yuko; Kajihara, Kenta; Sairaku, Akinori; Motoda, Chikaaki; Fujiwara, Mai; Watanabe, Yoshikazu; Yoshida, Yukihiko; Ohkubo, Kimie; Watanabe, Ichiro; Nogami, Akihiko; Hasegawa, Kanae; Watanabe, Hiroshi; Endo, Naoto; Aiba, Takeshi; Shimizu, Wataru; Ohno, Seiko; Horie, Minoru; Arihiro, Koji; Tashiro, Satoshi; Makita, Naomasa; Kihara, Yasuki
PLOS GENETICS   9(4) e1003364-e1003364   2013年   [査読有り]
小南 陽子,相方 浩,平松 憲,田中 未央,苗代 典昭,中原 隆志,本田 洋士,長沖 祐子,村上 英介,宮木 大輔,三木 大樹,河岡 友和,高木 慎太郎,平賀 伸彦,柘植 雅貴,芹川 正浩,今村 道雄,兵庫 秀幸,川上 由育,高橋 祥一,佐々木 民人,茶山 一彰
日本消化器病学会雑誌   110(3) 456-464   2013年3月   [査読有り]
Kohno, Tomohiko; Tsuge, Masataka; Hayes, C. Nelson; Hatakeyama, Tsuyoshi; Ohnishi, Mayu; Abe, Hiromi; Miki, Daiki; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Ochi, Hidenori; Tanaka, Shinji; Chayama, Kazuaki
ANTIVIRAL THERAPY   17(8) 1551-1561   2012年   [査読有り]
Hayes, C. Nelson; Akamatsu, Sakura; Tsuge, Masataka; Miki, Daiki; Akiyama, Rie; Abe, Hiromi; Ochi, Hidenori; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Aikata, Hiroshi; Kawaoka, Tomokazu; Kawakami, Yoshiiku; Ohishi, Waka; Chayama, Kazuaki
PLOS ONE   7(10) e47490-e47490   2012年10月   [査読有り]
Kawaoka, Tomokazu; Takahashi, Shoichi; Takaki, Shintaro; Hiramatsu, Akira; Waki, Koji; Hiraga, Nobuhiko; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Onoe, Takashi; Tashiro, Hirotaka; Ohdan, Hideki; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   27(9) 1467-1472   2012年   [査読有り]
Okazaki, Akihito; Hiraga, Nobuhiko; Imamura, Michio; Hayes, C. Nelson; Tsuge, Masataka; Takahashi, Shoichi; Aikata, Hiroshi; Abe, Hiromi; Miki, Daiki; Ochi, Hidenori; Tateno, Chise; Yoshizato, Katsutoshi; Ohdan, Hideki; Chayama, Kazuaki
HEPATOLOGY   56(2) 555-566   2012年   [査読有り]
Kawaoka, Tomokazu; Hiraga, Nobuhiko; Takahashi, Shoichi; Takaki, Shintaro; Tsuge, Masataka; Nagaoki, Yuko; Hashimoto, Yoshimasa; Katamura, Yoshio; Miki, Daiki; Hiramatsu, Akira; Waki, Koji; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Tashiro, Hirotaka; Ohdan, Hideki; Chayama, Kazuaki
INTERVIROLOGY   55(4) 306-310   2012年   [査読有り]
Ohnishi, Mayu; Tsuge, Masataka; Kohno, Tomohiko; Zhang, Yizhou; Abe, Hiromi; Hyogo, Hideyuki; Kimura, Yuki; Miki, Daiki; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Ochi, Hidenori; Hayes, C. Nelson; Tanaka, Shinji; Arihiro, Koji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   47(7) 834-844   2012年   [査読有り]
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Aikata, Hiroshi; Chayama, Kazuaki
CANCER SCIENCE   103(5) 846-850   2012年   [査読有り][招待有り]
Miki, Daiki; Ohishi, Waka; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Tsuge, Masataka; Imamura, Michio; Kamatani, Naoyuki; Nakamura, Yusuke; Chayama, Kazuaki
JOURNAL OF VIRAL HEPATITIS   19(2) E126-E133   2012年   [査読有り]
Kawaoka, Tomokazu; Aikata, Hiroshi; Miyaki, Daisuke; Murakami, Eisuke; Azakami, Takahiro; Takaki, Shintaro; Nagaoki, Yuko; Hashimoto, Yoshimasa; Katamura, Yoshio; Hiramatsu, Akira; Waki, Koji; Hiraga, Nobuhiko; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Takahashi, Shoichi; Ochi, Hidenori; Tashiro, Hirotaka; Ohdan, Hideki; Chayama, Kazuaki
HEPATOLOGY RESEARCH   41(11) 1126-1131   2011年   [査読有り]
Kawaoka, Tomokazu; Aikata, Hiroshi; Takaki, Shintaro; Hiramatsu, Akira; Waki, Koji; Hiraga, Nobuhiko; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Takahashi, Shoichi; Ochi, Hidenori; Tashiro, Hirotaka; Ohdan, Hideki; Chayama, Kazuaki
JOURNAL OF VIRAL HEPATITIS   18(10) E550-E560   2011年   [査読有り]
Mbarek, Hamdi; Ochi, Hidenori; Urabe, Yuji; Kumar, Vinod; Kubo, Michiaki; Hosono, Naoya; Takahashi, Atsushi; Kamatani, Yoichiro; Miki, Daiki; Abe, Hiromi; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Chayama, Kazuaki; Nakamura, Yusuke; Matsuda, Koichi
HUMAN MOLECULAR GENETICS   20(19) 3884-3892   2011年10月   [査読有り]
Abe, Hiromi; Hayes, C. Nelson; Ochi, Hidenori; Tsuge, Masataka; Miki, Daiki; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   83(9) 1597-1607   2011年   [査読有り]
Tsuge, Masataka; Fujimoto, Yoshifumi; Hiraga, Nobuhiko; Zhang, Yizhou; Ohnishi, Mayu; Kohno, Tomohiko; Abe, Hiromi; Miki, Daiki; Imamura, Michio; Takahashi, Shoichi; Ochi, Hidenori; Hayes, C. Nelson; Miya, Fuyuki; Tsunoda, Tatsuhiko; Chayama, Kazuaki
PLOS ONE   6(8) e23856-e23856   2011年8月   [査読有り]
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Yoshima, Tadahiko; Aikata, Hiroshi; Ikeda, Kenji; Kumada, Hiromitsu; Toyota, Joji; Morizono, Takashi; Tsunoda, Tatsuhiko; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Chayama, Kazuaki
NATURE GENETICS   43(8) 797-800   2011年   [査読有り]
Chayama, Kazuaki; Hayes, C. Nelson; Abe, Hiromi; Miki, Daiki; Ochi, Hidenori; Karino, Yoshiyasu; Toyota, Joji; Nakamura, Yusuke; Kamatani, Naoyuki; Sezaki, Hitomi; Kobayashi, Mariko; Akuta, Norio; Suzuki, Fumitaka; Kumada, Hiromitsu
JOURNAL OF INFECTIOUS DISEASES   204(1) 84-93   2011年7月   [査読有り]
Abe, Hiromi; Hayes, C. Nelson; Ochi, Hidenori; Maekawa, Toshiro; Tsuge, Masataka; Miki, Daiki; Mitsui, Fukiko; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Kubo, Michiaki; Nakamura, Yusuke; Chayama, Kazuaki
JOURNAL OF HEPATOLOGY   54(6) 1094-1101   2011年   [査読有り]
Azakami, Takahiro; Hayes, C. Nelson; Sezaki, Hitomi; Kobayashi, Mariko; Akuta, Norio; Suzuki, Fumitaka; Kumada, Hiromitsu; Abe, Hiromi; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Takahashi, Shoichi; Ochi, Hidenori; Nakamura, Yusuke; Kamatani, Naoyuki; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   83(6) 1048-1057   2011年   [査読有り]
Hayes, C. Nelson; Kobayashi, Mariko; Akuta, Norio; Suzuki, Fumitaka; Kumada, Hiromitsu; Abe, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Kamatani, Naoyuki; Nakamura, Yusuke; Chayama, Kazuaki
GUT   60(2) 261-267   2011年   [査読有り]
Miki, Daiki; Kubo, Michiaki; Takahashi, Atsushi; Yoon, Kyong-Ah; Kim, Jeongseon; Lee, Geon Kook; Zo, Jae Ill; Lee, Jin Soo; Hosono, Naoya; Morizono, Takashi; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Chayama, Kazuaki; Takahashi, Takashi; Inazawa, Johji; Nakamura, Yusuke; Daigo, Yataro
NATURE GENETICS   42(10) 893-896   2010年   [査読有り]

書籍等出版物

 
消化器・肝臓内科:3巻1号, pp60-68
三木大樹、茶山一彰 (担当:共著)
科学評論社   2018年   
臨牀消化器内科:30巻11号, pp1415-1420
相方浩、三木大樹、柘植雅貴、今村道雄、茶山一彰 (担当:共著)
日本メディカルセンター   2015年   
日本臨牀:73巻増刊号9, pp439-442
越智秀典、三木大樹、茶山一彰 (担当:共著)
日本臨牀社   2015年   
日本臨牀:73巻増刊号9, pp128-132
三木大樹、越智秀典、茶山一彰 (担当:共著)
日本臨牀社   2015年   
日本臨牀:73巻増刊号1, pp213-216
三木大樹、越智秀典、相方浩、茶山一彰 (担当:共著)
日本臨牀社   2015年   
日本医事新報:4698号, pp57
三木大樹、茶山一彰 (担当:共著)
日本医事新報社   2014年5月   
肝胆膵:63巻3号, pp471-485
工藤正俊、坂元亨宇、山下太郎、三木大樹 (担当:共著)
アークメディア   2014年3月   
肝胆膵:67巻1号, pp55-62
越智秀典、三木大樹、茶山一彰 (担当:共著)
アークメディア   2013年7月   
G.I.Research:20巻3号, pp22-26
三木大樹、越智秀典、相方浩、茶山一彰 (担当:共著)
先端医学社   2012年6月   

講演・口頭発表等

 
A COMPREHENSIVE ANALYSIS OF A WIDE RANGE OF LIVER DISEASES BY 16S rRNA SEQUENCING REVEALS CHARACTERISTIC PATTERNS OF GUT MICROBIOTA IN EACH ETIOLOGY
Daiki Miki, Yumi Shimomura, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Maiko Numba, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Grace Naswa Makokha, Tatsuhiko Tsunoda, Kazuaki Chayama
The Liver Meeting 2019   2019年11月11日   American Association for the Study of Liver Diseases
INDEPENDENT IMPACT OF POLYMORPHISM IN IRF5 AS WELL AS STAT4 ON HBV-RELATED HEPATOCARCINOGENESIS
Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Tatsuhiko Tsunoda, Kazuaki Chayama
The Liver Meeting 2019   2019年11月11日   American Association for the Study of Liver Diseases
ASSOCIATION OF FNDC5, PNPLA3 AND TM6SF2 POLYMORPHISMS WITH HEPATIC STEATOSIS IN NAFLD PATIENTS
Daiki Miki, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Nelson Hayes, Grace Naswa Makokha, Tatsuhiko Tsunoda, Kazuaki Chayama
The Liver Meeting 2019   2019年11月10日   American Association for the Study of Liver Diseases
DIFFERENTIAL EFFECTS OF HOST GENETIC FACTORS ON HCV PERSISTENCE ACCORDING TO HCV GENOTYPES
Daiki Miki, Tomokazu Kawaoka, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Tatsuhiko Tsunoda, Kazuaki Chayama
The Liver Meeting 2019   2019年11月10日   American Association for the Study of Liver Diseases
RESISTANCE ANALYSIS FOR GLECAPREVIR AND PIBRENTASVIR ON GENOTYPE 1b HEPATITIS C VIRUS INFECTION IN SUBGENOMIC REPLICON SYSTEMS AND HUMAN HEPATOCYTE TRANSPLANTED MICE
Mitsutaka Osawa, Michio Imamura, Takuro Uchida, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe-Chayama, Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata, Yuji Ishida, Chise Tateno, Yohei Miyayama, Makoto Hijikata, Kazuaki Chayama
The Liver Meeting 2019   2019年11月10日   American Association for the Study of Liver Diseases
TUMOR AND BLOOD FGFR4 LEVELS PREDICT THE EFFICACY OF LENVATINIB IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA
Masami Yamauchi, Atsushi Ono, Haruna Hatooka, Kenichiro Kodama, Peiyi Zhang, Yuji Teraoka, Kei Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Clair Nelson Hayes, Hiroshi Aikata, Kazuaki Chayama
The Liver Meeting 2019   2019年11月9日   American Association for the Study of Liver Diseases
PERMISSION OF HEPATITIS B VIRUS INFECTION IN Jak3KORag2KO MOUSE
Yuji Teraoka, Michio Imamura, Takuro Uchida, Kazuki Ohya, Mitsutaka Osawa, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Daiki Miki, Akira Hiramatsu, Hiromi Abe-Chayama, Nelson Hayes, Yuji Ishida, Chise Tateno, Hiroshi Aikata, Kazuaki Chayama
The Liver Meeting 2019   2019年11月9日   American Association for the Study of Liver Diseases
GENETIC POLYMORPHISM OF IP-10, NOT IFNL4 OR HLA-DPS, AFFECTS LIVER INFLAMMATION IN CHRONIC HEPATITIS B PATIENTS
Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Tatsuhiko Tsunoda, Kazuaki Chayama
The Liver Meeting 2019   2019年11月8日   American Association for the Study of Liver Diseases
EXPLORATORY ANALYSIS OF BIOMARKERS ASSOCIATED WITH CLINICAL OUTCOMES OF LENVATINIB IN HEPATOCELLULAR CARCINOMA
Atsushi Ono, Hiroshi Aikata, Masami Yamauchi, Kenichiro Kodama, Daiki Miki, Waka Ohishi, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Hiromi Abe-Chayama, Masataka Tsuge, Michio Imamura, Clair Nelson Hayes, Kazuaki Chayama
The Liver Meeting 2019   2019年11月8日   American Association for the Study of Liver Diseases
IRF5高発現に関連するSNPアレルはHBV関連肝癌の発症リスクを低下させる
三木大樹、柘植雅貴、山内理海、大野敦司、相方浩、角田達彦、茶山一彰
第78回日本癌学会学術総会   2019年9月26日   日本癌学会
膵癌患者の血中exosome のテトラスパニン発現プロファイル
辰川裕美子、三木大樹、芹川正浩、池本珠莉、平野哲朗、吹上綾美、森豪、中村真也、斎藤裕平、河村良太、津島健、栗原啓介、壷井智史、石井康隆、山内理海、茶山一彰
第105回日本消化器病学会総会   2019年5月10日   日本消化器病学会
Multiple genetic factors affecting nonalcoholic fatty liver disease and nonalcoholic steatohepatitis-related hepatocellular carcinoma in the Japanese population
Daiki Miki, Yuichi Hiyama, Atsushi Ono, Masami Yamauchi, Masataka Tsuge, Hiroshi Aikata, Tatsuhiko Tsunoda, Kazuaki Chayama
11th AACR-JCA Joint Conference   2019年2月10日   米国癌学会(AACR), 日本癌学会(JCA)
Association of TLL1 Polymorphism with Development of Hepatocellular Carcinoma after Hepatitis C Virus Eradication and Fibrosis Severity
Daiki Miki, Tomokazu Kawaoka, Yuko Nagaoki, Nelson Hayes, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Hiromi Abe-Chayama, Hidenori Ochi, Tatsuhiko Tsunoda, Kazuaki Chayama
The Liver Meeting 2018   2018年11月10日   American Association for the Study of Liver Diseases
Prevalence of NS5A Resistance Associated Variants in NS5A Inhibitor Treatment Failures and an Effective Treatment for NS5A-P32 Deleted Hepatitis C Virus in Humanized Mice
Yuji Teraoka, Takuro Uchida, Michio Imamura, Mitutaka Osawa, Tomokazu Kawaoka, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata, Daiki Miki, Hidenori Ochi, Yuji Ishida, Chise Tateno, Kazuaki Chayama
The Liver Meeting 2018   2018年11月9日   American Association for the Study of Liver Diseases
日本人における非アルコール性脂肪性肝疾患・非アルコール性脂肪肝炎関連肝細胞癌の発症に関連する宿主遺伝的要因
三木大樹、柘植雅貴、山内理海、相方浩、茶山一彰
第77回日本癌学会学術総会   2018年9月28日   日本癌学会
Hepatitis B virus up-regulates IL8 expression via endoplasmic reticulum stress and leads to suppress interferon responsiveness
Tsuge, Masataka; Hiraga, Nobuhiko; Uchida, Takuro; Murakami, Eisuke; Abe-Chayama, Hiromi; Miki, Daiki; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Chayama, Kazuaki
68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting   2017年10月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Characterizing the early immune response to hepatitis B virus infection using the human hepatocyte chimeric mouse model
Hayes, Nelson; Akamatsu, Sakura; Tsuge, Masataka; Miki, Daiki; Abe-Chayama, Hiromi; Imamura, Michio; Chayama, Kazuaki
68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting   2017年10月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Serum HMGB1 concentrations is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy
Ono, Atsushi; Masuda, Kazuhiko; Aikata, Hiroshi; Kawaoka, Tomokazu; Hayes, Nelson; Nakahara, Takashi; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Abe-Chayama, Hiromi; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting   2017年10月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Hepatocellular carcinoma development in hepatitis C virus patients who achieved sustained viral response by interferon therapy and direct anti-viral agents therapy
Nagaoki, Yuko; Imamura, Michio; Nakamura, Yuki; Morio, Kei; Nakahara, Takashi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Kawakami, Yoshiiku; Aikata, Hiroshi; Chayama, Kazuaki; Miki, Daiki
68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting   2017年10月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Efficacy and safety of edoxaban for treatment of portal vein thrombosis following danaparoid sodium in patients with liver cirrhosis
Nagaoki, Yuko; Aikata, Hiroshi; Nakamura, Yuki; Morio, Kei; Nakahara, Takashi; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting   2017年10月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Serial profiling of circulating tumor DNA identifies biomarkers for anti-VEGF chemotherapy in mCRC patients
Yamauchi, Masami; Chayama, Kazuaki; Urabe, Yuji; Ono, Atsushi; Ochi, Hidenori; Miki, Daiki
第15回日本臨床腫瘍学会学術集会   2017年7月   日本臨床腫瘍学会
Evaluation of antiviral effects of a novel site-specific pegylated interferon beta using humanized mouse model
Tsuge, Masataka; Uchida, Takuro; Kan, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Hayes, C. Nelson; Shimozono, Reiko; Iwamura, Tomokatsu; Chayama, Kazuaki
67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2016年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Protease inhibitor resistance remains even after mutant strains become undetectable using ultra-deep sequencing
Kan, Hiromi; Imamura, Michio; Hiraga, Nobuhiko; Hayes, C. Nelson; Uchida, Takuro; Miyaki, Eisuke; Tsuge, Masataka; Abe-Chayama, Hiromi; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2016年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
B型慢性肝炎病勢評価のための新規マーカーとしてのマイクロRNAの可能性
三木大樹、柘植雅貴、茶山一彰
第52回日本肝臓学会総会   2016年5月20日   日本肝臓学会
ウイルス性慢性肝炎の病態・病勢を反映し得る血清マイクロRNAの同定
三木大樹、柘植雅貴、阿部弘美、越智秀典、平賀伸彦、今村道雄、高橋祥一、相方浩、河岡友和、川上由育、大石和佳、茶山一彰
第102回日本消化器病学会総会   2016年4月21日   日本消化器病学会
Japanese genetic study could not suggest the importance of the NTCP locus for HBV persistence
Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K
The 25th Conference of the Asian Pacific Association for the Study of the Liver   2016年2月22日   Asian Pacific Association for the Study of the Liver (APASL)
The relationship between hepatocellular carcinoma development and reduced expression levels of the major germline genotype of PROSC, which is frequently deleted in hepatocellular carcinoma
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Akamatsu, Sakura; Ono, Atsushi; Nakahara, Takashi; Zhang, Yizhou; Masaki, Keiichi; Fujino, Hatsue; Miyaki, Eisuke; Kan, Hiromi; Uchida, Takuro; Hiraga, Nobuhiko; Tsuge, Masataka; Kawaoka, Tomokazu; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Circulating tumor DNA analysis for liver cancers and its usefulness as a liquid biopsy
Ono, Atsushi; Hayes, C. Nelson; Uchida, Takuro; Kan, Hiromi; Masaki, Keiichi; Nakahara, Takashi; Miki, Daiki; Kawaoka, Tomokazu; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Abe, Hiromi; Nakagawa, Hidewaki; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Rapid, sensitive, and accurate evaluation system for drug resistant strain (NS5A-Y93H) frequency in genotype 1b HCV
Ochi, Hidenori; Yoshimi, Satoshi; Murakami, Eisuke; Uchida, Takuro; Kan, Hiromi; Akamatsu, Sakura; Hayes, C. Nelson; Abe, Hiromi; Miki, Daiki; Hiraga, Nobuhiko; Imamura, Michio; Aikata, Hiroshi; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Genetic association study failed to confirm an association between the NTCP S267F mutation and persistence of hepatitis B virus or development of hepatocellular carcinoma in the Japanese population
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Akamatsu, Sakura; Ono, Atsushi; Nakahara, Takashi; Zhang, Yizhou; Masaki, Keiichi; Fujino, Hatsue; Miyaki, Eisuke; Kan, Hiromi; Uchida, Takuro; Hiraga, Nobuhiko; Tsuge, Masataka; Kawaoka, Tomokazu; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Genome-wide scan of miRNA polymorphisms revealed a suggestive association of miR-3143 with chronic hepatitis B virus infection
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Akamatsu, Sakura; Ono, Atsushi; Nakahara, Takashi; Zhang, Yizhou; Masaki, Keiichi; Fujino, Hatsue; Miyaki, Eisuke; Kan, Hiromi; Uchida, Takuro; Hiraga, Nobuhiko; Tsuge, Masataka; Kawaoka, Tomokazu; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Difference of intracellular responses by HBV genotype A and C infection in humanized mouse model
Tsuge, Masataka; Hiraga, Nobuhiko; Abe, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Hayes, C. Nelson; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
The impact of HLA-DQs and IFNL4 variant on hepatitis C virus-induced liver inflammation
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Akamatsu, Sakura; Ono, Atsushi; Nakahara, Takashi; Zhang, Yizhou; Masaki, Keiichi; Fujino, Hatsue; Miyaki, Eisuke; Kan, Hiromi; Uchida, Takuro; Hiraga, Nobuhiko; Tsuge, Masataka; Kawaoka, Tomokazu; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
Involvement of Endoplasmic Reticulum Stress Transducer BBF2H7 in Hepatocellular Carcinoma Promotion
Zhang, Yizhou; Hayes, Nelson; Tsuge, Masataka; Hiraga, Nobuhiko; Uchida, Takuro; Miki, Daiki; Abe, Hiromi; Chayama, Kazuaki
66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD)   2015年11月   American-Association-for-the-Study-of-Liver-Diseases (AASLD)
肝癌で欠損がみられる遺伝子の生殖細胞系列多型は自身の発現量を調節することで発癌に寄与しうる
三木大樹、相方浩、大野敦司、卜部祐司、柘植雅貴、川上由育、久保充明、中村祐輔、茶山一彰
第74回日本癌学会学術総会   2015年10月8日   日本癌学会
HBV感染に伴うmicroRNA発現変化とmiRNAによるHBV複製制御
柘植雅貴、平賀伸彦、村上英介、阿部弘美、三木大樹、河岡友和、平松憲、今村道雄、兵庫秀幸、川上由育、相方浩、越智秀典、茶山一彰
第51回日本肝臓学会総会   2015年5月22日   日本肝臓学会
HCV慢性感染肝組織内でのOAS1発現は自身近傍のSNPよりもIL28B近傍のSNPにより強く調節される
三木大樹、阿部弘美、ヘイズ・ネルソン、越智秀典、河岡友和、大野敦司、中原隆志、村上英介、柾木慶一、内田宅郎、菅宏美、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、茶山一彰
第51回日本肝臓学会総会   2015年5月21日   日本肝臓学会
HCV持続感染におけるIFNL4とHLA-DQの遺伝子多型間相互作用
三木大樹、越智秀典、阿部弘美、大野敦司、中原隆志、柾木慶一、村上英介、内田宅郎、菅宏美、河岡友和、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、茶山一彰
第101回日本消化器病学会総会   2015年4月23日   日本消化器病学会
The IL28B SNP has a stronger regulatory effect on the expression of OAS1 than a nearby SNP located downstream of OAS1 in chronic HCV patients
Miki, Daiki; Abe, Hiromi; Hayes, C. Nelson; Ochi, Hidenori; Kawaoka, Tomokazu; Akamatsu, Sakura; Ono, Atsushi; Nakahara, Takashi; Seki, Noriaki; Murakami, Eisuke; Zhang, Yizhou; Uchida, Takuro; Honda, Yohji; Masaki, Keiichi; Kan, Hiromi; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Kubo, Michiaki; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
Pretreatment induction of ISGs in the presence of IFNL4 in hepatocytes but not in white blood cells is related with poor induction of ISGs following IFN-alpha therapy
Abe, Hiromi; Hayes, C. Nelson; Hiraga, Nobuhiko; Imamura, Michio; Tsuge, Masataka; Miki, Daiki; Aikata, Hiroshi; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Yoshizato, Katsutoshi; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
A single amino acid substitution in HLA-DQB1 as well as an IFNL4 variant strongly affect susceptibility to chronic hepatitis C
Miki, Daiki; Ochi, Hidenori; Takahashi, Atsushi; Hayes, C. Nelson; Urabe, Yuji; Abe, Hiromi; Ono, Atsushi; Akamatsu, Sakura; Nakahara, Takashi; Seki, Noriaki; Murakami, Eisuke; Zhang, Yizhou; Uchida, Takuro; Honda, Yohji; Yoshimi, Satoshi; Kobayashi, Tomoki; Masaki, Keiichi; Kan, Hiromi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Takahashi, Shoichi; Akuta, Norio; Suzuki, Fumitaka; Ikeda, Kenji; Kumada, Hiromitsu; Karino, Yoshiyasu; Toyota, Joji; Tsunoda, Tatsuhiko; Kubo, Michiaki; Kamatani, Naoyuki; Nakamura, Yusuke; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
Nucleotide analogue improves interferon responsiveness in HBV-infected human hepatocytes
Tsuge, Masataka; Hiraga, Nobuhiko; Murakami, Eisuke; Imamura, Michio; Abe, Hiromi; Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
Hepatitis B virus infection efficiency and immune response decreases with cell density in primary cultured hepatocytes
Hayes, C. Nelson; Abe, Hiromi; Akamatsu, Sakura; Hiraga, Nobuhiko; Imamura, Michio; Tsuge, Masataka; Miki, Daiki; Aikata, Hiroshi; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
IFNL4/IL-28B haplotype structure and predictability of their variations for spontaneous and treatment-induced clearance of HCV infection in the Japanese population
Ochi, Hidenori; Miki, Daiki; Hayes, C. Nelson; Abe, Hiromi; Kubo, Michiaki; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
Germline variants of highly point-mutated genes in hepatocellular carcinoma do not have strong effects on HCV-related hepatocarcinogenesis
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Ono, Atsushi; Akamatsu, Sakura; Urabe, Yuji; Masaki, Keiichi; Abe, Hiromi; Kawaoka, Tomokazu; Nakahara, Takashi; Seki, Noriaki; Murakami, Eisuke; Zhang, Yizhou; Uchida, Takuro; Honda, Yohji; Kan, Hiromi; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Kubo, Michiaki; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
Two microRNA polymorphisms are associated with hepatitis B virus-related but not hepatitis C virus-related hepatocellular carcinoma in the Japanese population
Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Kawaoka, Tomokazu; Ono, Atsushi; Akamatsu, Sakura; Nakahara, Takashi; Seki, Noriaki; Murakami, Eisuke; Zhang, Yizhou; Uchida, Takuro; Honda, Yohji; Masaki, Keiichi; Kan, Hiromi; Tsuge, Masataka; Hiraga, Nobuhiko; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Kubo, Michiaki; Chayama, Kazuaki
65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases   2014年11月   American-Association-for-the-Study-of-Liver-Diseases
わが国におけるmiR-146aおよびmiR-196a2の遺伝子多型と肝炎ウイルス関連肝発癌リスク
三木大樹、相方浩、大野敦司、卜部祐司、柘植雅貴、川上由育、久保充明、中村祐輔、茶山一彰
第73回日本癌学会学術総会   2014年9月26日   日本癌学会
HCV関連肝疾患におけるIFNL3(IL28B),IFNL4遺伝子型乖離例の頻度と抗ウイルス療法の効果の検討
狩野吉康、山口将功、木村睦海、荒川智宏、中島知明、桑田靖昭、小関至、佐藤隆啓、大村卓味、髭修平、豊田成司、三木大樹、越智秀典、茶山一彰
第50回日本肝臓学会総会   2014年5月30日   日本肝臓学会
HCV感染におけるIFNL4の多型の違いによるIFN-λsの発現量とインターフェロン投与前後のインターフェロン誘導遺伝子の発現量の関係
阿部弘美、三木大樹、平賀伸彦、今村道雄、柘植雅貴、小林知樹、河岡友和、川上由育、相方浩、越智秀典、茶山一彰
第50回日本肝臓学会総会   2014年5月30日   日本肝臓学会
HCV慢性化におけるHLA-DQB1の重要性:ゲノムワイド関連解析
三木大樹、越智秀典、ヘイズ・ネルソン、阿部弘美、大野敦司、中原隆志、村上英介、河岡友和、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、高橋祥一、茶山一彰
第50回日本肝臓学会総会   2014年5月30日   日本肝臓学会

競争的資金等の研究課題

 
C型肝炎ウイルス排除治療による肝硬変患者のアウトカムに関する研究開発
日本医療研究開発機構(AMED): 肝炎等克服実用化研究事業「肝炎等克服緊急対策研究事業」(AMED)
研究期間: 2019年4月 - 2022年3月    代表者: 竹原 徹郎
高効率感染細胞系と長期持続肝炎マウスモデルを用いたHBV排除への創薬研究
日本医療研究開発機構(AMED): 肝炎等克服実用化研究事業「B型肝炎創薬実用化等研究事業」(AMED)
研究期間: 2017年4月 - 2022年3月    代表者: 茶山一彰
C型肝炎ウイルス排除後の病態、生命予後、QOLに関する包括的研究
日本医療研究開発機構(AMED): 肝炎等克服実用化研究事業「肝炎等克服緊急対策研究事業」(AMED)
研究期間: 2017年4月 - 2020年3月    代表者: 茶山一彰
肝炎ウイルス非存在下肝発癌に関連する新規遺伝的要因による肝発癌リスク評価法の開発
日本学術振興会: 科学研究費助成事業 基盤(C)
研究期間: 2017年4月 - 2020年3月    代表者: 三木大樹
2本鎖DNAを使用せず高度の安全性を保証する遺伝子治療の開発
日本学術振興会: 科学研究費助成事業 挑戦的研究(開拓)
研究期間: 2017年4月 - 2020年3月    代表者: 茶山一彰
医学・医療における臨床・全ゲノム・オミックスのビッグデータの解析に基づく疾患の原因探索・亜病態分類とリスク予測
科学技術振興機構: JST戦略的創造研究推進事業 チーム型研究(CREST)
研究期間: 2018年4月 - 2020年3月    代表者: 角田達彦
東広島市発、日本酒酒粕を用いた腸内環境を整える機能性食品の開発
東広島市: 東広島市政策課題共同研究事業
研究期間: 2018年6月 - 2019年3月    代表者: 三木大樹
肝疾患における腸内細菌叢の乱れが血液中マイクロベシクルに与える影響の検討とバイオマーカーとしての開発
ブリストル・マイヤーズ スクイブ株式会社: 2017年度「ブリストル・マイヤーズ スクイブ(株)研究助成」
研究期間: 2017年11月 - 2019年3月    代表者: 三木大樹
C型肝炎ウイルス排除後の肝発癌に関連する宿主遺伝的要因の探索とリスク評価法の確立
公益財団法人ウイルス肝炎研究財団: 平成28年度肝炎に関する研究助成事業「研究奨励金」(公益財団法人ウイルス肝炎研究財団)
研究期間: 2017年3月 - 2018年3月    代表者: 三木大樹
新規バイオマーカーとしての肝がん特異的エクソソームおよび内包miRNAの網羅的探索
公益財団法人武田科学振興財団: 2016年度医学系研究奨励(公益財団法人武田科学振興財団)
研究期間: 2016年11月 - 2018年3月    代表者: 三木大樹
免疫ゲノム学的アプローチによる肝発がん機構の解明
ブリストル・マイヤーズ株式会社: 2016年度「ブリストル・マイヤーズ株式会社 研究・教育助成」
研究期間: 2016年11月 - 2018年3月    代表者: 三木大樹
ゲノムから表現型までの多階層統合的解析による肥満および糖尿病と脂肪肝炎との相互作用メカニズムの解明
鈴木謙三記念医科学応用研究財団: 平成27年度調査研究助成金(公益財団法人鈴木謙三記念医科学応用研究財団)
研究期間: 2015年4月 - 2017年3月    代表者: 三木大樹
ヒト肝細胞キメラマウスを用いた薬剤耐性、臓器不全等治療困難症例に対する病態解析と根治的治療法の開発に関する研究
厚生労働省、日本医療研究開発機構(AMED): 肝炎等克服実用化研究事業(厚生労働省、AMED)
研究期間: 2014年4月 - 2017年3月    代表者: 茶山一彰
ウイルスセンシング経路の遺伝的多様性がウイルス性肝疾患の進展に及ぼす影響の検討
日本学術振興会: 科学研究費助成事業 若手(B)
研究期間: 2014年4月 - 2017年3月    代表者: 三木大樹
ウイルス性慢性肝疾患の病態に影響を与えるmiRNA多型の網羅的探索
厚生労働省、日本医療研究開発機構(AMED): 肝炎等克服実用化研究事業(厚生労働省、AMED)
研究期間: 2013年4月 - 2016年3月    代表者: 三木大樹
A genome-wide association study identified a novel susceptibility locus for hepatocellular carcinoma in chronic hepatitis C virus carriers (AASLD 2011, San Francisco)
日本肝臓学会: 国際学会参加に伴う費用の一部助成(日本肝臓学会)
研究期間: 2011年11月 - 2011年11月    代表者: 三木大樹

社会貢献活動

 
C型肝炎
【運営参加・支援】  広島県健康福祉局薬務課  2019年9月14日 - 2019年9月14日
わかりやすい肝臓のお話
【運営参加・支援】  一般社団法人日本肝臓学会  2019年7月28日 - 2019年7月28日
C型肝炎
【運営参加・支援】  広島県健康福祉局薬務課  2018年9月24日 - 2018年9月24日
肝臓病教室
【運営参加・支援】  広島大学病院肝疾患相談室  2018年1月31日
肝臓病教室
【運営参加・支援】  広島大学病院肝疾患相談室  2017年12月6日