We report the Suzaku detection of the earliest X-ray eclipse seen in the recurrent nova U Scorpii 2010. A target-of-opportunity observation 15 days after the outburst found a 27% ± 5% dimming in the 0.2-1.0 keV energy band at the predicted center of an eclipse. In comparison with the X-ray eclipse depths seen at two later epochs by XMM-Newton, the source region shrank by about 10%-20% between days 15 and 35 after the outburst. The X-ray eclipses appear to be deeper than or similar to contemporaneous optical eclipses, suggesting the X-ray and optical source region extents are comparable on day 15. We raise the possibility of the energy dependency in the photon escape regions, and that this would be a result of the supersoft X-ray opacity being higher than the Thomson scattering opacity at the photosphere due to bound-free transitions in abundant metals that are not fully ionized. Assuming a spherically symmetric model, we constrain the mass-loss rate as a function of time. For a ratio of actual to Thomson opacity of 10-100 in supersoft X-rays, we find an ejecta mass of about 10-7-10-6 M . © 2013. The American Astronomical Society. All rights reserved..