土本大介 (Daisuke Tsuchimoto) - マイポータル

基本情報

所属: 九州大学生体防御医学研究所脳機能制御学分野

J-GLOBAL ID: 201801009423888674
researchmap会員ID: B000304499

哺乳動物のDNA損傷やヌクレオチド損傷に対する防御機構とその欠損の影響を研究しています。特に神経系や免疫系への影響に興味を持っています。

研究キーワード

研究分野

委員歴

2017年4月 - 2021年3月

九州大学, 部局広報担当スポークスパーソン
2018年8月 - 2018年10月

九州大学, 平成30年度馬出地区4部局合同男女共同参画ＦＤワーキンググループ委員

受賞

2016年12月

優秀ポスター賞, 日本分子生物学会

論文

APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.

Carol E Schrader, Travis Williams, Klaus Pechhold, Erin K Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu

Journal of immunology (Baltimore, Md. : 1950) 210(11) 1804-1814 2023年6月1日
APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

Md Akram Hossain, Yunfeng Lin, Garrett Driscoll, Jia Li, Anne McMahon, Joshua Matos, Haichao Zhao, Daisuke Tsuchimoto, Yusaku Nakabeppu, Jianjun Zhao …

Frontiers in Cell and Developmental Biology 9 2021年11月2日
間接蛍光抗体法による多発性硬化症患者血清中の抗オリゴデンドロサイト抗体の検討

藤井敬之, 宮地佑希野, 山崎亮, 土本大介, 迫田礼子, 福元尚子, 松下拓也, 中別府雄作, 吉良潤一, 磯部紀子

神経免疫学 26(1) 122-122 2021年10月
MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.

Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M LaFerla, Yusaku Nakabeppu

Scientific reports 11(1) 5819-5819 2021年3月23日
Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury.

Yi Hu, Chun Yang, Tania Amorim, Mohsin Maqbool, Jenny Lin, Chen Li, Chuanfeng Fang, Li Xue, Ariel Kwart, Hua Fang …

Cancer research 81(3) 713-723 2021年2月1日
Serum Anti-oligodendrocyte Autoantibodies in Patients With Multiple Sclerosis Detected by a Tissue-Based Immunofluorescence Assay.

Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe …

Frontiers in neurology 12 681980-681980 2021年
Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy.

Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu

JCI insight 5(22) 2020年11月19日
8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes.

Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami, Yusaku Nakabeppu

Progress in neurobiology 180 101613-101613 2019年9月査読有り
A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.

Takayuki Fujii, Ryo Yamasaki, Kyoko Iinuma, Daisuke Tsuchimoto, Yoshinori Hayashi, Ban-Yu Saitoh, Takuya Matsushita, Mizuho A Kido, Shinichi Aishima, Hiroshi Nakanishi …

Annals of neurology 84(2) 208-224 2018年8月査読有り
2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Shinji Asada, Eiko Ohta, Yoriko Akimoto, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu

SCIENTIFIC REPORTS 7(1) 6528 2017年7月査読有り
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Michel J. Massaad, Jia Zhou, Daisuke Tsuchimoto, Janet Chou, Haifa Jabara, Erin Janssen, Salome Glauzy, Brennan G. Olson, Henner Morbach, Toshiro K. Ohsumi …

JOURNAL OF CLINICAL INVESTIGATION 126(11) 4219-4236 2016年11月査読有り
PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.

Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, Sakumi K, Torisu T, Chida K, Sueishi K …

Genes to cells : devoted to molecular & cellular mechanisms 21(10) 1030-1048 2016年10月査読有り
Deoxyinosine triphosphate induces MLH1/PMS2-and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yasuto Yoneshima, Nona Abolhassani, Teruaki Iyama, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Tetsuo Noda, Daisuke Tsuchimoto, Yusaku Nakabeppu

SCIENTIFIC REPORTS 6 32849 2016年9月査読有り
MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

S. Oka, J. Leon, D. Tsuchimoto, K. Sakumi, Y. Nakabeppu

ONCOGENESIS 3 2014年10月
Fosb Gene Products Contribute to Excitotoxic Microglial Activation by Regulating the Expression of Complement C5a Receptors in Microglia

Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Yoshinori N. Ohnishi, Kosuke Kajitani, Daisuke Tsuchimoto, Eric J. Nestler, Yusaku Nakabeppu

GLIA 62(8) 1284-1298 2014年8月査読有り
Apurinic/Apyrimidinic Endonuclease 2 Regulates the Expansion of Germinal Centers by Protecting against Activation-Induced Cytidine Deaminase-Independent DNA Damage in B Cells

Jeroen E. J. Guikema, Erin K. Linehan, Nada Esa, Daisuke Tsuchimoto, Yusaku Nakabeppu, Robert T. Woodland, Carol E. Schrader

JOURNAL OF IMMUNOLOGY 193(2) 931-939 2014年7月査読有り
Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Janet Stavnezer, Erin K. Linehan, Mikayla R. Thompson, Ghaith Habboub, Anna J. Ucher, Tatenda Kadungure, Daisuke Tsuchimoto, Yusaku Nakabeppu, Carol E. Schrader

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111(25) 9217-9222 2014年6月査読有り
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Nona Abolhassani, Hiroko Nomaru, Kunihiko Sakumi, Hidetaka Yemada, Yusaku Nakabeppu

JOURNAL OF CLINICAL INVESTIGATION 122(12) 4344-4361 2012年12月査読有り
Cancer-Related PRUNE2 Protein Is Associated with Nucleotides and Is Highly Expressed in Mature Nerve Tissues

Eiji Iwama, Daisuke Tsuchimoto, Teruaki Iyama, Kunihiko Sakumi, Akira Nakagawara, Koichi Takayama, Yoichi Nakanishi, Yusaku Nakabeppu

JOURNAL OF MOLECULAR NEUROSCIENCE 44(2) 103-114 2011年6月査読有り
Apurinic/Apyrimidinic Endonuclease 2 Is Necessary for Normal B Cell Development and Recovery of Lymphoid Progenitors after Chemotherapeutic Challenge

Jeroen E. J. Guikema, Rachel M. Gerstein, Erin K. Linehan, Erin K. Cloherty, Eric Evan-Browning, Daisuke Tsuchimoto, Yusaku Nakabeppu, Carol E. Schrader

JOURNAL OF IMMUNOLOGY 186(4) 1943-1950 2011年2月査読有り